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Data movement between the main memory and the processor is a key contributor to execution time and energy consumption in memory-intensive applications. This data movement bottleneck can be alleviated using Processing-in-Memory (PiM). One…

Applications of Binary Neural Networks (BNNs) are promising for embedded systems with hard constraints on computing power. Contrary to conventional neural networks with the floating-point datatype, BNNs use binarized weights and activations…

Emerging Technologies · Computer Science 2022-11-14 Mahdi Zahedi , Taha Shahroodi , Stephan Wong , Said Hamdioui

Processing-using-DRAM has been proposed for a limited set of basic operations (i.e., logic operations, addition). However, in order to enable full adoption of processing-using-DRAM, it is necessary to provide support for more complex…

3D point cloud neural networks have significantly enhanced the perceptual capabilities of resource-limited mobile intelligent systems. However, despite the transformative impact, the point cloud algorithm suffers from substantial memory…

Hardware Architecture · Computer Science 2026-03-24 Dengfeng Wang , Shunqin Cai , Yanan Sun

Processing-In-Memory (PIM) is a novel approach that augments existing DRAM memory chips with lightweight logic. By allowing to offload computations to the PIM system, this architecture allows for circumventing the data-bottleneck problem…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-01-18 André Lopes , Daniel Castro , Paolo Romano

Transcriptome assembly from RNA-Seq reads is an active area of bioinformatics research. The ever-declining cost and the increasing depth of RNA-Seq have provided unprecedented opportunities to better identify expressed transcripts. However,…

Computational Engineering, Finance, and Science · Computer Science 2013-06-07 Tin Chi Nguyen , Zhiyu Zhao , Dongxiao Zhu

Sequence alignment is a fundamental process in computational biology which identifies regions of similarity in biological sequences. With the exponential growth in the volume of data in bioinformatics databases, the time, processing power,…

Hardware Architecture · Computer Science 2025-07-31 Nasrin Akbari , Mehdi Modarressi , Alireza Khadem

Processing-using-DRAM has been proposed for a limited set of basic operations (i.e., logic operations, addition). However, in order to enable the full adoption of processing-using-DRAM, it is necessary to provide support for more complex…

Today's systems are overwhelmingly designed to move data to computation. This design choice goes directly against at least three key trends in systems that cause performance, scalability and energy bottlenecks: (1) data access from memory…

Hardware Architecture · Computer Science 2019-03-12 Onur Mutlu , Saugata Ghose , Juan Gómez-Luna , Rachata Ausavarungnirun

Our ISCA 2015 paper provides a new programmable processing-in-memory (PIM) architecture and system design that can accelerate key data-intensive applications, with a focus on graph processing workloads. Our major idea was to completely…

Hardware Architecture · Computer Science 2023-06-28 Junwhan Ahn , Sungpack Hong , Sungjoo Yoo , Onur Mutlu , Kiyoung Choi

Graph processing requires irregular, fine-grained random access patterns incompatible with contemporary off-chip memory architecture, leading to inefficient data access. This inefficiency makes graph processing an extremely memory-bound…

Hardware Architecture · Computer Science 2025-03-11 Changmin Shin , Jaeyong Song , Hongsun Jang , Dogeun Kim , Jun Sung , Taehee Kwon , Jae Hyung Ju , Frank Liu , Yeonkyu Choi , Jinho Lee

Resistive random access memory (ReRAM)-based processing-in-memory (PIM) architectures have demonstrated great potential to accelerate Deep Neural Network (DNN) training/inference. However, the computational accuracy of analog PIM is…

This paper is focused in designing an efficient on-line algorithm to reconstruct a DNA sequence and search the genes in it, we assume that the segment have no mutation or reading error, the algorithm is based on de Bruijn Graph for…

Data Structures and Algorithms · Computer Science 2017-06-12 Juan David Arcila Moreno , Santiago Passos , Mauricio Toro

Motivation: Seed location filtering is critical in DNA read mapping, a process where billions of DNA fragments (reads) sampled from a donor are mapped onto a reference genome to identify genomic variants of the donor. State-of-the-art read…

Sequence alignment is a memory bound computation whose performance in modern systems is limited by the memory bandwidth bottleneck. Processing-in-memory architectures alleviate this bottleneck by providing the memory with computing…

Hardware Architecture · Computer Science 2023-03-28 Safaa Diab , Amir Nassereldine , Mohammed Alser , Juan Gómez-Luna , Onur Mutlu , Izzat El Hajj

Genome assembly from the high-throughput sequencing (HTS) reads is a fundamental yet challenging computational problem. An intrinsic challenge is the uncertainty caused by the widespread repetitive elements. Here we get around the…

Genomics · Quantitative Biology 2016-09-13 Anqi Wang , Zheng Li , Zhanyu Wang , Lei M. Li

Large Language Models (LLMs) have become essential in a variety of applications due to their advanced language understanding and generation capabilities. However, their computational and memory requirements pose significant challenges to…

Hardware Architecture · Computer Science 2024-12-02 Cristobal Ortega , Yann Falevoz , Renaud Ayrignac

Accelerating end-to-end inference of transformer-based large language models (LLMs) is a critical component of AI services in datacenters. However, diverse compute characteristics of end-to-end LLM inference present challenges as previously…

Convolutional neural networks (CNNs) play a key role in deep learning applications. However, the large storage overheads and the substantial computation cost of CNNs are problematic in hardware accelerators. Computing-in-memory (CIM)…

Hardware Architecture · Computer Science 2021-05-26 Syuan-Hao Sie , Jye-Luen Lee , Yi-Ren Chen , Chih-Cheng Lu , Chih-Cheng Hsieh , Meng-Fan Chang , Kea-Tiong Tang

Developing kernels for Processing-In-Memory (PIM) platforms poses unique challenges in data management and parallel programming on limited processing units. Although software development kits (SDKs) for PIM, such as the UPMEM SDK, provide…

Hardware Architecture · Computer Science 2025-10-21 Krystian Chmielewski , Jarosław Ławnicki , Uladzislau Lukyanau , Tadeusz Kobus , Maciej Maciejewski