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Related papers: An Interventionist Approach to Mediation Analysis

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The ability to answer causal questions is crucial in many domains, as causal inference allows one to understand the impact of interventions. In many applications, only a single intervention is possible at a given time. However, in some…

Machine Learning · Statistics 2022-10-12 Olivier Jeunen , Ciarán M. Gilligan-Lee , Rishabh Mehrotra , Mounia Lalmas

Mediation analysis breaks down the causal effect of a treatment on an outcome into an indirect effect, acting through a third group of variables called mediators, and a direct effect, operating through other mechanisms. Mediation analysis…

Applications · Statistics 2025-05-13 Judith Abécassis , Houssam Zenati , Sami Boumaïza , Julie Josse , Bertrand Thirion

Causal mediation analysis is a useful tool for epidemiological research, but it has been criticized for relying on a "cross-world" independence assumption that is empirically difficult to verify and problematic to justify based on…

Methodology · Statistics 2021-09-02 Ryan M. Andrews , Vanessa Didelez

Causal mediation analysis aims at disentangling a treatment effect into an indirect mechanism operating through an intermediate outcome or mediator, as well as the direct effect of the treatment on the outcome of interest. However, the…

Econometrics · Economics 2020-05-05 Martin Huber , Lukáš Lafférs

Mediation analysis has been widely used to investigate how a treatment influences an outcome through intermediate variables, known as mediators. Analyzing a mediation mechanism typically requires assessing multiple model parameters that…

Methodology · Statistics 2025-10-01 Hanying Jiang , Kris Sankaran , Yinqiu He

Controlled Direct Effect (CDE) is one of the causal estimands used to evaluate both exposure and mediation effects on an outcome. When there are unmeasured confounders existing between the mediator and the outcome, the ordinary…

Methodology · Statistics 2024-10-30 Shunichiro Orihara , Shinpei Imori , Kosuke Morikawa , Atsushi Goto , Masataka Taguri

Methods to identify cause-effect relationships currently mostly assume the variables to be scalar random variables. However, in many fields the objects of interest are vectors or groups of scalar variables. We present a new constraint-based…

Methodology · Statistics 2022-12-02 Jonas Wahl , Urmi Ninad , Jakob Runge

Although the exposure can be randomly assigned in studies of mediation effects, any form of direct intervention on the mediator is often infeasible. As a result, unmeasured mediator-outcome confounding can seldom be ruled out. We propose…

Methodology · Statistics 2021-09-30 BaoLuo Sun , Ting Ye

Mediation analysis is difficult when the number of potential mediators is larger than the sample size. In this paper we propose new inference procedures for the indirect effect in the presence of high-dimensional mediators for linear…

Methodology · Statistics 2019-10-29 Ruixuan Rachel Zhou , Liewei Wang , Sihai Dave Zhao

Mediation analysis is widely used for exploring treatment mechanisms; however, it faces challenges when nonignorable missing confounders are present. Efficient inference of mediation effects and the efficiency loss due to nonignorable…

Methodology · Statistics 2026-04-22 Jiawei Shan , Wei Li , Chunrong Ai

Path-specific effects are a broad class of mediated effects from an exposure to an outcome via one or more causal pathways with respect to some subset of intermediate variables. The majority of the literature concerning estimation of…

Our work addresses a fundamental problem in the context of counterfactual inference for Markov Decision Processes (MDPs). Given an MDP path $\tau$, this kind of inference allows us to derive counterfactual paths $\tau'$ describing what-if…

Artificial Intelligence · Computer Science 2025-03-28 Milad Kazemi , Jessica Lally , Ekaterina Tishchenko , Hana Chockler , Nicola Paoletti

The goal of causal mediation analysis, often described within the potential outcomes framework, is to decompose the effect of an exposure on an outcome of interest along different causal pathways. Using the assumption of sequential…

Methodology · Statistics 2021-11-09 Lexi Rene , Antonio R. Linero , Elizabeth Slate

Counterfactual reasoning is pivotal in human cognition and especially important for providing explanations and making decisions. While Judea Pearl's influential approach is theoretically elegant, its generation of a counterfactual scenario…

Artificial Intelligence · Computer Science 2024-11-01 Guang-Yuan Hao , Jiji Zhang , Biwei Huang , Hao Wang , Kun Zhang

In interventional health studies, causal mediation analysis can be employed to investigate mechanisms through which the intervention affects the targeted health outcome. Identifying direct and indirect (i.e. mediated) effects from empirical…

There have been numerous publications on the advantages and disadvantages of estimating natural (pure) effects compared to controlled effects. One of the main criticisms of natural effects is that it requires an additional assumption for…

Methodology · Statistics 2024-03-01 Ian Shrier

The direct effect of one eventon another can be defined and measured byholding constant all intermediate variables between the two.Indirect effects present conceptual andpractical difficulties (in nonlinear models), because they cannot be…

Artificial Intelligence · Computer Science 2013-01-14 Judea Pearl

We show that it is possible to understand and identify a decision maker's subjective causal judgements by observing her preferences over interventions. Following Pearl [2000], we represent causality using causal models (also called…

Theoretical Economics · Economics 2024-01-23 Joseph Y. Halpern , Evan Piermont

In (Beckers, 2025) I introduced nondeterministic causal models as a generalization of Pearl's standard deterministic causal models. I here take advantage of the increased expressivity offered by these models to offer a novel definition of…

Artificial Intelligence · Computer Science 2025-03-12 Sander Beckers

In recent years, there has been an increasing interest in studying causality-related properties in machine learning models generally, and in generative models in particular. While that is well motivated, it inherits the fundamental…

Artificial Intelligence · Computer Science 2020-01-30 Ioannis Papantonis , Vaishak Belle
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