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Experiment directed simulation is a technique to minimally bias molecular dynamics simulations to match experimentally observed results. The method improves accuracy but does not address the sampling problem of molecular dynamics…

Chemical Physics · Physics 2019-02-07 Dilnoza B Amirkulova , Andrew D White

Restricted Boltzmann Machines (RBMs) are one of the fundamental building blocks of deep learning. Approximate maximum likelihood training of RBMs typically necessitates sampling from these models. In many training scenarios, computationally…

Machine Learning · Computer Science 2014-10-02 Guillaume Desjardins , Heng Luo , Aaron Courville , Yoshua Bengio

In this paper we develop a new general Bayesian methodology that simultaneously estimates parameters of interest and the marginal likelihood of the model. The proposed methodology builds on Simulated Tempering, which is a powerful algorithm…

Computation · Statistics 2019-06-03 Biljana Jonoska Stojkova , David A. Campbell

Dynamics under which a system of Ising spins relaxes to a stationary state with Bolzmann-Gibbs measure and which do not fulfil the condition of detailed balance are irreversible and asymmetric. We revisit the problem of the determination of…

Statistical Mechanics · Physics 2015-06-15 Claude Godreche

Parallel tempering is a generic Markov chain Monte Carlo sampling method which allows good mixing with multimodal target distributions, where conventional Metropolis-Hastings algorithms often fail. The mixing properties of the sampler…

Computation · Statistics 2012-05-08 Blazej Miasojedow , Eric Moulines , Matti Vihola

The equilibrium ensemble approach to disordered systems is used to investigate the critical behaviour of the two dimensional Ising model in presence of quenched random site dilution. The numerical transfer matrix technique in semi- infinite…

Statistical Mechanics · Physics 2009-10-31 Giorgio Mazzeo , Reimer Kuehn

We review a selection of methods for performing enhanced sampling in molecular dynamics simulations. We consider methods based on collective variable biasing and on tempering, and offer both historical and contemporary perspectives. In…

Statistical Mechanics · Physics 2014-01-03 Cameron Abrams , Giovanni Bussi

We show that the acceptance probability for swaps in the parallel tempering Monte Carlo method for classical canonical systems is given by a universal function that depends on the average statistical fluctuations of the potential and on the…

Chemical Physics · Physics 2009-11-10 Cristian Predescu , Mihaela Predescu , Cristian V. Ciobanu

New algorithm of the finite lattice method is presented to generate the high-temperature expansion series of the Ising model. It enables us to obtain much longer series in three dimensions when compared not only to the previous algorithm of…

High Energy Physics - Lattice · Physics 2009-11-07 H. Arisue , T. Fujiwara

Using MCMC to sample from a target distribution, $\pi(x)$ on a $d$-dimensional state space can be a difficult and computationally expensive problem. Particularly when the target exhibits multimodality, then the traditional methods can fail…

Methodology · Statistics 2026-01-14 Nicholas G. Tawn , Gareth O. Roberts

We implement a variational quantum algorithm for Gibbs state preparation of a transverse-field Ising model on IonQ's quantum computers. To this end, we train the variational parameters via classical simulation and perform state tomography…

All-atom molecular dynamics (MD) computer simulations are a valuable tool for characterizing the conformational ensembles of intrinsically disordered proteins (IDPs). IDP conformational ensembles are highly heterogeneous and contain…

Chemical Physics · Physics 2025-05-06 Jaya Krishna Koneru , Korey M. Reid , Paul Robustelli

Generative models have advanced significantly in sampling material systems with continuous variables, such as atomistic structures. However, their application to discrete variables, like atom types or spin states, remains underexplored. In…

Statistical Mechanics · Physics 2025-11-18 Ping Tuo , Zezhu Zeng , Jiale Chen , Bingqing Cheng

The spin system of the $2d$ Ising model having a hexagonal-lattice is simulated using non-deterministic Cellular Automata. The method to implement this program is outlined and our results show a good approximation to the exact analytic…

Statistical Mechanics · Physics 2020-04-22 Jahangir Mohammed , Swapna Mahapatra

The development of physical simulators, called Ising machines, that sample from low energy states of the Ising Hamiltonian has the potential to drastically transform our ability to understand and control complex systems. However, most of…

Computational Physics · Physics 2021-03-10 Timothee Leleu , Farad Khoyratee , Timothee Levi , Ryan Hamerly , Takashi Kohno , Kazuyuki Aihara

Methods that combine collective variable (CV) based enhanced sampling and global tempering approaches are used in speeding-up the conformational sampling and free energy calculation of large and soft systems with a plethora of energy…

Computational Physics · Physics 2021-09-01 Anji Babu Kapakayala , Nisanth N. Nair

Composite systems, where couplings are of two types, a combination of strong dilute and weak dense couplings of Ising spins, are examined through the replica method. The dilute and dense parts are considered to have independent canonical…

Disordered Systems and Neural Networks · Physics 2009-11-13 Jack Raymond , David Saad

We demonstrate the applicability of the $\epsilon$-convergence algorithm in extracting the critical temperatures and critical exponents of three-dimensional Ising models. We analyze the low temperature magnetization as well as high…

Statistical Mechanics · Physics 2024-10-22 M V Vismaya , M V Sangaranarayanan

We study the efficiency of parallel tempering Monte Carlo technique for calculating true ground states of the Edwards-Anderson spin glass model. Bimodal and Gaussian bond distributions were considered in two and three-dimensional lattices.…

Statistical Mechanics · Physics 2015-05-13 F. Roma , S. Risau-Gusman , A. J. Ramirez-Pastor , F. Nieto , E. E. Vogel

We propose a method for efficient simulations in extended ensembles, useful, e.g., for the study of problems with complex energy landscapes and for free energy calculations. The main difficulty in such simulations is the estimation of the a…

Statistical Mechanics · Physics 2012-05-29 Jack Lidmar