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The big crux with drug delivery to human lungs is that the delivered dose at the local site of action is unpredictable and very difficult to measure, even a posteriori. It is highly subject-specific as it depends on lung morphology,…

Mechanistic mathematical models of within-host viral dynamics are tools for understanding how a virus' biology and its interaction with the immune system shape the infectivity of a host. The biology of the process is encoded by the…

Applications · Statistics 2025-12-11 Dylan J. Morris , Lauren Kennedy , Andrew J. Black

In this paper, we develop a method to estimate the infection-rate of a disease, over a region, as a field that varies in space and time. To do so, we use time-series of case-counts of symptomatic patients as observed in the areal units that…

Applications · Statistics 2024-06-19 Cosmin Safta , Wyatt Bridgman , Jaideep Ray

Coronavirus disease 2019 (COVID-19) has become a global pandemic infectious respiratory disease with high mortality and infectiousness. This paper investigates respiratory droplet transmission, which is critical to understanding, modeling…

Fluid Dynamics · Physics 2021-02-03 Hongping Wang , Zhaobin Li , Xinlei Zhang , Lixing Zhu , Yi Liu , Shizhao Wang

Wireless tomography is a technique for inferring a physical environment within a monitored region by analyzing RF signals traversed across the region. In this paper, we consider wireless tomography in a two and higher dimensionally…

Information Theory · Computer Science 2014-07-10 Kazushi Takemoto , Takahiro Matsuda , Shinsuke Hara , Kenichi Takizawa , Fumie Ono , Ryu Miura

This paper presents an approach to estimating the health effects of an environmental hazard. The approach is general in nature, but is applied here to the case of air pollution. It uses a computer model involving ambient pollution and…

Applications · Statistics 2007-11-01 Gavin Shaddick , Duncan Lee , James V. Zidek , Ruth Salway

Purpose Infectious agents, such as SARS-CoV-2, can be carried by droplets expelled during breathing. The spatial dissemination of droplets varies according to their initial velocity. After a short literature review, our goal was to…

Quantitative Methods · Quantitative Biology 2021-01-12 Antoine Giovanni , Thomas Radulesco , Gilles Bouchet , Alexia Mattei , Joana Révis , Estelle Bogdanski , Justin Michel

We study the spreading of viruses, such as SARS-CoV-2, by airborne aerosols, via a new first-passage-time problem for Lagrangian tracers that are advected by a turbulent flow: By direct numerical simulations of the three-dimensional (3D)…

Fluid Dynamics · Physics 2020-08-19 Akhilesh Kumar Verma , Akshay Bhatnagar , Dhrubaditya Mitra , Rahul Pandit

Auscultation is a key method for early diagnosis of respiratory and pulmonary diseases, relying on skilled healthcare professionals. However, the process is often subjective, with variability between experts. As a result, numerous deep…

Sound · Computer Science 2025-09-05 Yun Chu , Qiuhao Wang , Enze Zhou , Qian Liu , Gang Zheng

Breathing rate (BR), minute ventilation (VE), and other respiratory parameters are essential for real-time patient monitoring in many acute health conditions, such as asthma. The clinical standard for measuring respiration, namely…

Signal Processing · Electrical Eng. & Systems 2020-11-26 Ridwan Alam , David B. Peden , John C. Lach

How is the progression of a virus influenced by properties intrinsic to individual cells? We address this question by studying the susceptibility of cells infected with two strains of the human respiratory syncytial virus (RSV-A and RSV-B)…

Methodology · Statistics 2014-07-15 Joshua Goldstein , Murali Haran , Ivan Simeonov , John Fricks , Francesca Chiaromonte

The ability to monitor respiratory rate is extremely important for medical treatment, healthcare and fitness sectors. In many situations, mobile methods, which allow users to undertake every day activities, are required. However, current…

Computer Vision and Pattern Recognition · Computer Science 2017-09-22 Youngjun Cho , Simon J. Julier , Nicolai Marquardt , Nadia Bianchi-Berthouze

Respiratory auscultation can help healthcare professionals detect abnormal respiratory conditions if adventitious lung sounds are heard. The state-of-the-art artificial intelligence technologies based on deep learning show great potential…

The analysis of diffusion processes in real-world propagation scenarios often involves estimating variables that are not directly observed. These hidden variables include parental relationships, the strengths of connections between nodes,…

Social and Information Networks · Computer Science 2016-05-12 Shohreh Shaghaghian , Mark Coates

Besides mimicking bio-chemical and multi-scale communication mechanisms, molecular communication forms a theoretical framework for virus infection processes. Towards this goal, aerosol and droplet transmission has recently been modeled as a…

Information Theory · Computer Science 2021-01-29 Peter Adam Hoeher , Martin Damrath , Sunasheer Bhattacharjee , Max Schurwanz

Accurate identification of respiratory viruses (RVs) is critical for outbreak control and public health. This study presents a diagnostic system that combines Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR)…

Machine Learning · Computer Science 2025-04-15 Wenwen Zhang , Zhouzhuo Tang , Yingmei Feng , Xia Yu , Qi Jie Wang , Zhiping Lin

Exposure to bio-aerosols such as mold spores and pollen can lead to adverse health effects. There is a need for a portable and cost-effective device for long-term monitoring and quantification of various bio-aerosols. To address this need,…

Applied Physics · Physics 2022-11-23 Yi Luo , Yijie Zhang , Tairan Liu , Alan Yu , Yichen Wu , Aydogan Ozcan

The present study focuses on the receptor driven endocytosis typical of viral entry into a cell. A locally increased density of receptors at the time of contact between the cell and the virus is necessary in this case. The virus is…

Cell Behavior · Quantitative Biology 2021-01-28 T. Wiegold , S. Klinge , R. P. Gilbert , G. A. Holzapfel

The globally supported social distancing rules to prevent airborne transmission of COVID-19 assume small saliva droplets evaporate fast and large ones, which contain most viral copies, fall fast to the ground. However, during evaporation,…

Fluid Dynamics · Physics 2023-11-24 Gizem Ozler , Holger Grosshans

We combine a pedestrian dynamics model with a contact tracing method to simulate the initial spreading of a highly infectious airborne disease in a confined environment. We focus on a medium size population (up to 1000 people) with a small…

Physics and Society · Physics 2020-04-22 Krithika Rathinakumar , Annalisa Quaini