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We developed an explainable artificial intelligence (AI) early warning score (xAI-EWS) system for early detection of acute critical illness. While maintaining a high predictive performance, our system explains to the clinician on which…

Understanding how human mobility and information propagation influence the course of an epidemic remains a key challenge in digital epidemiology. In this work, we develop a new awareness-based, event-triggered epidemic model embedded within…

Physics and Society · Physics 2026-05-06 Yusheng Li , Minyu Feng , Liang-jian Deng , Matjaž Perc , Jürgen Kurths

Non-Equilibrium Social Science (NESS) emphasizes dynamical phenomena, for instance the way political movements emerge or competing organizations interact. This paper argues that predictive analysis is an essential element of NESS, occupying…

Social and Information Networks · Computer Science 2013-01-03 Richard Colbaugh , Kristin Glass , Curtis Johnson

In this paper we make the first steps to bridge the gap between classic control theory and modern, network-based epidemic models. In particular, we apply nonlinear model predictive control (NMPC) to a pairwise ODE model which we use to…

Classical Analysis and ODEs · Mathematics 2014-02-11 Fanni Sélley , Ádám Besenyei , Istvan Z. Kiss , Péter L. Simon

Early Warning Signals (EWSs) are vital for implementing preventive measures before a disease turns into a pandemic. While new diseases exhibit unique behaviors, they often share fundamental characteristics from a dynamical systems…

Machine Learning · Computer Science 2025-01-15 Reza Miry , Amit K. Chakraborty , Russell Greiner , Mark A. Lewis , Hao Wang , Tianyu Guan , Pouria Ramazi

Recent work has shown that different theoretical approaches to the dynamics of the Susceptible-Infected-Susceptible (SIS) model for epidemics lead to qualitatively different estimates for the position of the epidemic threshold in networks.…

Statistical Mechanics · Physics 2012-10-17 Silvio C. Ferreira , Claudio Castellano , Romualdo Pastor-Satorras

Distribution system state estimation (DSSE) plays a crucial role in the real-time monitoring, control, and operation of distribution networks. Besides intensive computational requirements, conventional DSSE methods need high-quality…

Systems and Control · Electrical Eng. & Systems 2024-08-05 Renyou Xie , Xin Yin , Chaojie Li , Guo Chen , Nian Liu , Bo Zhao , Zhaoyang Dong

World models have emerged as a unifying paradigm for learning latent dynamics, simulating counterfactual futures, and supporting planning under uncertainty. In this paper, we argue that computational epidemiology is a natural and…

Machine Learning · Computer Science 2026-04-14 Zeeshan Memon , Yiqi Su , Christo Kurisummoottil Thomas , Walid Saad , Liang Zhao , Naren Ramakrishnan

We study the tipping point collective dynamics of an adaptive susceptible-infected-susceptible (SIS) epidemiological network in a data-driven, machine learning-assisted manner. We identify a parameter-dependent effective stochastic…

Machine Learning · Computer Science 2023-11-14 Nikolaos Evangelou , Tianqi Cui , Juan M. Bello-Rivas , Alexei Makeev , Ioannis G. Kevrekidis

Clinical Decision Support Systems (CDSSs) provide reasoning and inquiry guidance for physicians, yet they face notable challenges, including high maintenance costs and low generalization capability. Recently, Large Language Models (LLMs)…

Computation and Language · Computer Science 2026-04-24 Yue Guo , Fanfu Wang , Jianwei Lv , Xincheng Shi , Yuchen Li , Youya Wang , Yunsheng Zeng , Yujing Liu , Yunhao Qiao , Gen Li , Junfeng Wang , Bo Yuan

Many Artificial Intelligence systems depend on the agent's updating its beliefs about the world on the basis of experience. Experiments constitute one type of experience, so scientific methodology offers a natural environment for examining…

Artificial Intelligence · Computer Science 2013-04-08 Harold P. Lehmann

Artificial intelligence (AI) systems increasingly shape how people access health information, make medical decisions, and receive care -- yet epidemiology lacks frameworks for measuring AI exposure or studying its health effects at the…

Other Statistics · Statistics 2026-04-16 Harsh Parikh , Tyler McCormick , Emily Johnson , Leo Hickey , Megan Ranney , Bhramar Mukherjee

Health-policy planning requires evidence on the burden that epidemics place on healthcare systems. Multiple, often dependent, datasets provide a noisy and fragmented signal from the unobserved epidemic process including transmission and…

Applications · Statistics 2024-09-11 Alice Corbella , Anne M Presanis , Paul J Birrell , Daniela De Angelis

The COVID-19 pandemic highlighted the critical role of human behavior in influencing infectious disease transmission and the need for models capturing this complex dynamic. We present an agent-based model integrating an epidemiological…

Social and Information Networks · Computer Science 2023-12-07 Konstantinos Mitsopoulos , Lawrence Baker , Christian Lebiere , Peter Pirolli , Mark Orr , Raffaele Vardavas

Sophisticated cyber attacks present significant challenges for organizations in detecting and preventing such threats. To address this critical need for advanced defense mechanisms, we propose an Ensemble Defense System (EDS). An EDS is a…

Cryptography and Security · Computer Science 2024-01-09 Sarah Alharbi , Arshiya Khan

This document analyzes the role of data-driven methodologies in Covid-19 pandemic. We provide a SWOT analysis and a roadmap that goes from the access to data sources to the final decision-making step. We aim to review the available…

Populations and Evolution · Quantitative Biology 2020-06-11 Teodoro Alamo , D. G. Reina , Pablo Millán

Humanitarian crises, such as the 2014 West Africa Ebola epidemic, challenge information management and thereby threaten the digital resilience of the responding organizations. Crisis information management (CIM) is characterised by the…

Computers and Society · Computer Science 2022-01-11 David Paulus , Ramian Fathi , Frank Fiedrich , Bartel Van de Walle , Tina Comes

Modern epidemiological analytics increasingly use machine learning models that offer strong prediction but often lack calibrated uncertainty. Bayesian methods provide principled uncertainty quantification, yet are viewed as difficult to…

Machine Learning · Statistics 2025-11-18 Debashis Chatterjee

The COVID-19 pandemic has highlighted the need to upgrade systems for infectious disease surveillance and forecasting and modeling of the spread of infection, both of which inform evidence-based public health guidance and policies. Here, we…

Artificial intelligence promises to revolutionise medicine, yet its impact remains limited because of the pervasive translational gap. We posit that the prevailing technology-centric approaches underpin this challenge, rendering such…

Human-Computer Interaction · Computer Science 2025-06-06 Kacper Sokol , James Fackler , Julia E Vogt