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We show that disordered boundaries destroy bulk phase separation in scalar active systems in dimension $d<d_c=3$. This is in strong contrast with the equilibrium case where boundaries have no impact on the bulk of phase-separated systems.…

Soft Condensed Matter · Physics 2022-04-20 Ydan Ben Dor , Sunghan Ro , Yariv Kafri , Mehran Kardar , Julien Tailleur

The phase separation in lipid bilayers that include negatively charged lipids is examined experimentally. We observed phase-separated structures and determined the membrane miscibility temperatures in several binary and ternary lipid…

Soft Condensed Matter · Physics 2014-10-16 Hiroki Himeno , Naofumi Shimokawa , Shigeyuki Komura , David Andelman , Tsutomu Hamada , Masahiro Takagi

We propose a framework to study the spatio-temporal evolution of liquid-liquid phase separation of weak polyelectrolytes in ionic solutions. Unlike strong polyelectrolytes, which carry a fixed charge, the charge state of weak…

Soft Condensed Matter · Physics 2025-03-19 Giulia Laura Celora , Ralf Blossey , Andreas Munch , Barbara Wagner

Transcription Factors (TFs) are proteins crucial for regulating gene expression. Effective regulation requires the TFs to rapidly bind to their correct target, enabling the cell to respond efficiently to stimuli such as nutrient…

Biological Physics · Physics 2025-12-04 Wencheng Ji , Ori Hachmo , Naama Barkai , Ariel Amir

Cells contain multiple condensates which spontaneously form due to the heterotypic interactions between their components. Although the proteins and disordered region sequences that are responsible for condensate formation have been…

Soft Condensed Matter · Physics 2024-06-25 Kyosuke Adachi , Kyogo Kawaguchi

We review understanding of kinetics of fluid phase separation in various space dimensions. Morphological differences, percolating or disconnected, based on overall composition in a binary liquid or density in a vapor-liquid system, have…

Statistical Mechanics · Physics 2020-06-05 Subir K. Das , Sutapa Roy , Jiarul Midya

Phase separation in the Hubbard model is investigated with the dynamical cluster approximation. We find that it is present in the paramagnetic solution for values of filling smaller than one and at finite temperature when a positive…

Strongly Correlated Electrons · Physics 2007-05-23 A. Macridin , M. Jarrell , Th. Maier

Simulation studies of the phase diagram of repulsive active Brownian particles in three dimensions reveal that the region of motility-induced phase separation between a high and low density phase is enclosed by a region of gas-crystal phase…

Statistical Mechanics · Physics 2021-01-27 Francesco Turci , Nigel B. Wilding

Phase separation of two phase separating solutes in a common solvent can result in mesoscale (micron-sized) droplets with complex topologies of the domains of each solute within each droplet. Such topologies have been observed in-vitro in…

Soft Condensed Matter · Physics 2025-07-31 Amit Kumar , Gary H. Karpen , Samuel A. Safran

Studies of active matter, from molecular assemblies to animal groups, have revealed two broad classes of behavior: a tendency to align yields orientational order and collective motion, whereas particle repulsion leads to self-trapping and…

Soft Condensed Matter · Physics 2021-11-23 Jie Zhang , Ricard Alert , Jing Yan , Ned S. Wingreen , Steve Granick

We deduce the mixing-demixing phase diagram for binary liquid mixtures in an electric field for various electrode geometries and arbitrary constitutive relation for the dielectric constant. By focusing on the behavior of the liquid-liquid…

Soft Condensed Matter · Physics 2013-07-18 Jennifer Galanis , Yoav Tsori

Membraneless droplets or liquid condensates formed via liquid-liquid phase separation (LLPS) play a pivotal role in cell biology and hold potential for biomedical engineering. While membraneless droplets are often studied in the context of…

Soft Condensed Matter · Physics 2025-11-07 Chenxi Liu , Ding Cao , Siyu Liu , Yilin Wu

Depth-averaged systems of equations describing the motion of fluid-sediment mixtures have been widely adopted by scientists in pursuit of models that can predict the paths of dangerous overland flows of debris. As models have become…

Fluid Dynamics · Physics 2026-04-07 Jake Langham , Xiannan Meng , Jamie P. Webb , Chris G. Johnson , J. M. N. T. Gray

Understanding how red blood cell (RBC) suspensions navigate porous materials is critical for for both fundamental physiology, such as maternal-fetal exchange in the placenta, and transformative biomedical applications, including rapid,…

Soft Condensed Matter · Physics 2025-09-03 Sampad Laha , Ananta Kumar Nayak , Alexander Farutin , Suman Chakraborty , Chaouqi Misbah

Motivated by the idea that intrinsically disordered proteins (IDPs) condense into liquid-like droplets within cells, we carry out Monte Carlo simulations of a polymer lattice model to study the relationship between charge patterning and…

Soft Condensed Matter · Physics 2019-12-11 Nicholas A. S. Robichaud , Ivan Saika-Voivod , Stefan Wallin

A theory for sequence dependent liquid-liquid phase separation (LLPS) of intrinsically disordered proteins (IDPs) in the study of biomolecular condensates is formulated by extending the random phase approximation (RPA) and field-theoretic…

Biomolecules · Quantitative Biology 2022-11-28 Jonas Wessén , Suman Das , Tanmoy Pal , Hue Sun Chan

Phase separation is a fundamental phenomenon that produces spatially heterogeneous patterns in soft matter. In this Lecture Note we show that phase separation in these materials generally belongs to what we call "viscoelastic phase…

Soft Condensed Matter · Physics 2013-07-08 Hajime Tanaka

Coherent misfitting precipitates in elastically stressed media such as $\gamma \prime$ particles in nickel-based super-alloys show various splitting patterns such as doublets, quartets, or octets due to their misfit strain energy. While it…

Materials Science · Physics 2007-05-23 Pil-Ryung Cha , Dong_Hee Yeon , Jong-Kyu Yoon

Spontaneous phase separation, or demixing, is important in biological phenomena such as cell sorting. In particle-based models, an open question is whether differences in diffusivity can drive such demixing. While…

Soft Condensed Matter · Physics 2023-07-10 Erin McCarthy , Ojan Damavandi , Raj Kumar Manna , M. Lisa Manning

The cellular cytoplasm is organized into compartments. Phase separation is a simple manner to create membrane-less compartments in order to confine and localize particles like proteins. In many cases these particles are bound to fluctuating…

Statistical Mechanics · Physics 2020-09-16 G. David , J. -C. Walter , C. P. Broedersz , J. Dorignac , F. Geniet , A. Parmeggiani , N. -O. Walliser , J. Palmeri