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Modern machine learning systems have been applied successfully to a variety of tasks in recent years but making such systems robust against adversarially chosen modifications of input instances seems to be a much harder problem. It is…

Quantum Physics · Physics 2021-12-20 Khashayar Barooti , Grzegorz Głuch , Ruediger Urbanke

In this paper we present a simulation environment enhanced with parallel processing which can be used on personal computers, based on a high-level user interface developed on Mathematica\copyright which is connected to C++ code in order to…

Quantum Physics · Physics 2011-03-09 Sandra Díaz-Pier , Salvador E. Venegas-Andraca , José Luis Gómez-Muñoz

In modelling complex processes, the potential past data that influence future expectations are immense. Models that track all this data are not only computationally wasteful but also shed little light on what past data most influence the…

Quantum annealing algorithms belong to the class of metaheuristic tools, applicable for solving binary optimization problems. Hardware implementations of quantum annealing, such as the quantum annealing machines produced by D-Wave Systems,…

Quantum Physics · Physics 2017-09-18 Florian Neukart , David Von Dollen , Christian Seidel , Gabriele Compostella

Quadratic Unconstrained Binary Optimization (QUBO) is a standard NP-hard optimization problem. Recently, it has gained renewed interest through quantum computing, as QUBOs directly reduce to the Ising model, on which quantum annealing…

Quantum Physics · Physics 2026-03-16 Katalin Friedl , Levente Gegő , László Kabódi , Viktória Nemkin

We lay the foundation for a benchmarking methodology for assessing current and future quantum computers. We pose and begin addressing fundamental questions about how to fairly compare computational devices at vastly different stages of…

Quantum Physics · Physics 2016-04-04 Ojas Parekh , Jeremy Wendt , Luke Shulenburger , Andrew Landahl , Jonathan Moussa , John Aidun

In recent years, advanced deep neural networks have required a large number of parameters for training. Therefore, finding a method to reduce the number of parameters has become crucial for achieving efficient training. This work proposes a…

Quantum computing promises to solve difficult optimization problems in chemistry, physics and mathematics more efficiently than classical computers, but requires fault-tolerant quantum computers with millions of qubits. To overcome errors…

Databases · Computer Science 2021-07-23 Tobias Fankhauser , Marc E. Solèr , Rudolf M. Füchslin , Kurt Stockinger

Quantum annealing offers a promising paradigm for solving NP-hard combinatorial optimization problems, but its practical application is severely hindered by two challenges: the complex, manual process of translating problem descriptions…

Machine Learning · Computer Science 2025-09-03 Huixiang Zhang , Mahzabeen Emu , Salimur Choudhury

Combinatorial optimization problems are typically formulated using Quadratic Unconstrained Binary Optimization (QUBO), where constraints are enforced through penalty terms that introduce auxiliary variables and rapidly increase Hamiltonian…

Quantum Physics · Physics 2026-02-10 Shashank Sanjay Bhat , Peiyong Wang , Joseph West , Udaya Parampalli

Variational quantum algorithms (VQAs) have the potential of utilizing near-term quantum machines to gain certain computational advantages over classical methods. Nevertheless, modern VQAs suffer from cumbersome computational overhead,…

Quantum Physics · Physics 2021-06-25 Yuxuan Du , Yang Qian , Dacheng Tao

Quantum neural networks (QNNs) provide expressive probabilistic models by leveraging quantum superposition and entanglement, yet their practical training remains challenging due to highly oscillatory loss landscapes and noise inherent to…

Quantum Physics · Physics 2026-01-26 Jaemin Seo

Boltzmann Machines constitute a class of neural networks with applications to image reconstruction, pattern classification and unsupervised learning in general. Their most common variants, called Restricted Boltzmann Machines (RBMs) exhibit…

Quantum Physics · Physics 2020-03-30 Lorenzo Rocutto , Claudio Destri , Enrico Prati

Quantum computers progress toward outperforming classical supercomputers, but quantum errors remain their primary obstacle. The key to overcoming errors on near-term devices has emerged through the field of quantum error mitigation,…

Quantum Physics · Physics 2025-05-14 Haoran Liao , Derek S. Wang , Iskandar Sitdikov , Ciro Salcedo , Alireza Seif , Zlatko K. Minev

Quadratic Unconstrained Binary Optimization (QUBO) problems are NP-hard problems and many real-world problems can be formulated as QUBO. Currently there are no algorithms known that can solve arbitrary instances of NP-hard problems…

Quantum Physics · Physics 2023-12-20 Christian Münch , Fritz Schinkel , Sebastian Zielinski , Stefan Walter

Quantum machine learning algorithms have emerged to be a promising alternative to their classical counterparts as they leverage the power of quantum computers. Such algorithms have been developed to solve problems like electronic structure…

Chemical Physics · Physics 2021-10-29 Manas Sajjan , Shree Hari Sureshbabu , Sabre Kais

AlphaFold has achieved groundbreaking advancements in protein structure prediction, exerting profound influence across biology, medicine, and drug discovery. However, its reliance on multiple sequence alignment (MSA) is inherently…

Quantum Physics · Physics 2025-06-03 Rong Chen , Quan-Xin Mei , Wen-Ding Zhao , Lin Yao , Hao-Xiang Yang , Shun-Yao Zhang , Jiao Chen , Hong-Lin Li

In this paper, we study the computational complexity of the quadratic unconstrained binary optimization (QUBO) problem under the functional problem FP^NP categorization. We focus on four sub-classes: (1) When all coefficients are integers…

Computational Complexity · Computer Science 2022-02-21 Hirotoshi Yasuoka

One of the main challenges in drug discovery is to find molecules that bind specifically and strongly to their target protein while having minimal binding to other proteins. By predicting binding affinity, it is possible to identify the…

Quantum Physics · Physics 2023-01-19 L. Domingo , M. Djukic , C. Johnson , F. Borondo

The digital transformation that Telecommunications and ICT domains are crossing today, is posing several new challenges to Telecom Operators. These challenges require solving complex problems such as: dimensioning and scheduling of…

Quantum Physics · Physics 2022-05-04 Michele Amoretti , Davide Ferrari , Antonio Manzalini