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In comparison with individual testing, group testing (also known as pooled testing) is more efficient in reducing the number of tests and potentially leading to tremendous cost reduction. As indicated in the recent article posted on the US…

Populations and Evolution · Quantitative Biology 2021-06-16 Yi-Jheng Lin , Che-Hao Yu , Tzu-Hsuan Liu , Cheng-Shang Chang , Wen-Tsuen Chen

Detection of rare traits or diseases in a large population is challenging. Pool testing allows covering larger swathes of population at a reduced cost, while simplifying logistics. However, testing precision decreases as it becomes unclear…

Information Theory · Computer Science 2021-06-22 Éric Brier , Megi Dervishi , Rémi Géraud-Stewart , David Naccache , Ofer Yifrach-Stav

The problem of Group Testing is to identify defective items out of a set of objects by means of pool queries of the form "Does the pool contain at least a defective?". The aim is of course to perform detection with the fewest possible…

Statistical Mechanics · Physics 2009-11-13 M. Mézard , M. Tarzia , C. Toninelli

As humanity struggles to contain the global Covid-19 infection, prophylactic actions are grandly slowed down by the shortage of testing kits. Governments have taken several measures to work around this shortage: the FDA has become more…

Consider a collection of objects, some of which may be `bad', and a test which determines whether or not a given sub-collection contains no bad objects. The non-adaptive pooling (or group testing) problem involves identifying the bad…

Combinatorics · Mathematics 2016-09-06 David J. Balding , David C. Torney

The usual problem for group testing is this: For a given number of individuals and a given prevalence, how many tests T* are required to find every infected individual? In real life, however, the problem is usually different: For a given…

Applications · Statistics 2021-07-21 Matthew Aldridge

We study the problem of group testing with non-identical, independent priors. So far, the pooling strategies that have been proposed in the literature take the following approach: a hand-crafted test design along with a decoding strategy is…

Information Theory · Computer Science 2022-01-31 Sundara Rajan Srinivasavaradhan , Pavlos Nikolopoulos , Christina Fragouli , Suhas Diggavi

Group testing is the process of pooling arbitrary subsets from a set of $n$ items so as to identify, with a minimal number of tests, a "small" subset of $d$ defective items. In "classical" non-adaptive group testing, it is known that when…

Information Theory · Computer Science 2018-09-21 Venkata Gandikota , Elena Grigorescu , Sidharth Jaggi , Samson Zhou

When testing for a disease such as COVID-19, the standard method is individual testing: we take a sample from each individual and test these samples separately. An alternative is pooled testing (or "group testing"), where samples are mixed…

Applications · Statistics 2021-12-14 Matthew Aldridge , David Ellis

Pooling specimens, a well-accepted sampling strategy in biomedical research, can be applied to reduce the cost of studying biomarkers. Even if the cost of a single assay is not a major restriction in evaluating biomarkers, pooling can be a…

Applications · Statistics 2012-03-01 Enrique F. Schisterman , Albert Vexler , Aijun Ye , Neil J. Perkins

We consider the optimal strategy for laboratory testing of biological samples when we wish to know the results for each sample rather than the average prevalence of positive samples. If the proportion of positive samples is low considerable…

Quantitative Methods · Quantitative Biology 2010-07-29 Brian G. Williams

Pooled testing offers an efficient solution to the unprecedented testing demands of the COVID-19 pandemic, although with potentially lower sensitivity and increased costs to implementation in some settings. Assessments of this trade-off…

Applications · Statistics 2021-07-13 Saskia Comess , Hannah Wang , Susan Holmes , Claire Donnat

Non-adaptive group testing refers to the problem of inferring a sparse set of defectives from a larger population using the minimum number of simultaneous pooled tests. Recent positive results for noiseless group testing have motivated the…

Information Theory · Computer Science 2021-07-16 Gabriel Arpino , Nicolò Grometto , Afonso S. Bandeira

The group testing problem concerns discovering a small number of defective items within a large population by performing tests on pools of items. A test is positive if the pool contains at least one defective, and negative if it contains no…

Information Theory · Computer Science 2026-05-15 Matthew Aldridge , Oliver Johnson , Jonathan Scarlett

Group testing is a screening strategy that involves dividing a population into several disjointed groups of subjects. In its simplest implementation, each group is tested with a single test in the first phase, while in the second phase only…

COVID-19 has resulted in a global health crisis that may become even more acute over the upcoming months. One of the main reasons behind the current rapid growth of COVID-19 in the U.S. population is the limited availability of testing kits…

Information Theory · Computer Science 2020-04-13 Krishna R. Narayanan , Anoosheh Heidarzadeh , Ramanan Laxminarayan

Repeated asymptomatic screening for SARS-CoV-2 promises to control spread of the virus but would require too many resources to implement at scale. Group testing is promising for screening more people with fewer test resources: multiple…

Populations and Evolution · Quantitative Biology 2020-11-18 Yifan Lin , Yuxuan Ren , Jingyuan Wan , Massey Cashore , Jiayue Wan , Yujia Zhang , Peter Frazier , Enlu Zhou

The paper develops methods to construct a one-stage optimal design of dilution experiments under the total available volume constraint typical for bio-medical applications. We consider various design criteria based on the Fisher information…

Statistics Theory · Mathematics 2013-05-08 Maryam Zolghadr , Sergei Zuyev

The corona virus disease 2019 (COVID-19) caused by the novel corona virus has an exponential rate of infection. COVID-19 is particularly notorious as the onset of symptoms in infected patients are usually delayed and there exists a large…

Methodology · Statistics 2020-04-16 Lakshmi N. Theagarajan

Choosing an optimal strategy for hierarchical group testing is an important problem for practitioners who are interested in disease screening with limited resources. For example, when screening for infectious diseases in large populations,…

Methodology · Statistics 2020-02-27 Yaakov Malinovsky , Gregory Haber , Paul S. Albert
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