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Ion channels play a key role in regulating cell behavior and in electrical signaling. In these settings, polar and charged functional groups -- as well as protein response -- compensate for dehydration in an ion-dependent way, giving rise…

Mesoscale and Nanoscale Physics · Physics 2017-08-22 Subin Sahu , Massimiliano Di Ventra , Michael Zwolak

The number of precise conductance measurements in nanopores is quickly growing. In order to clarify the dominant mechanisms at play and facilitate the characterization of such systems for which there is still no clear consensus, we propose…

Soft Condensed Matter · Physics 2018-07-25 Manoel Manghi , John Palmeri , Khadija Yazda , Francois Henn , Vincent Jourdain

Nanopores attracted a great deal of scientific interest as templates for biological sensors as well as model systems to understand transport phenomena at the nanoscale. The experimental and theoretical analysis of nanopores has been so far…

There has been tremendous experimental progress in the last decade in identifying the structure and function of biological pores (ion channels) and fabricating synthetic pores. Despite this progress, many questions still remain about the…

Soft Condensed Matter · Physics 2015-03-17 Michael Zwolak , James Wilson , Massimiliano Di Ventra

We employ molecular dynamics simulations to investigate ion and water transport driven by an electric field through quasi-two-dimensional nanoslits with a tapered geometry. Despite the absence of surface charge on the channel walls and the…

Soft Condensed Matter · Physics 2025-09-29 Tim Veenstra , Gerardo Campos-Villalobos , Giuliana Giunta , René van Roij , Marjolein Dijkstra

Modulating ion transport through nanoporous membranes is critical to many important chemical and biological separation processes. The corresponding transport timescales, however, are often too long to capture accurately using conventional…

Statistical Mechanics · Physics 2022-12-23 Brian A Shoemaker , Tiago S Domingues , Amir Haji-Akbari

Ion transporters in Nature exhibit a wealth of complex transport properties such as voltage gating, activation, and mechanosensitive behavior. When combined, such processes result in advanced ionic machines achieving active ion transport,…

Soft Condensed Matter · Physics 2020-05-08 Laetitia Jubin , Anthony R. Poggioli , Alessandro Siria , Lydéric Bocquet

The permeation, rejection, and transport of electrolytes in water-filled nanopores are critical to ion current gating and desalinalion processes in synthetic porous membranes and the functions of biological ion channels. Mile the effects of…

Statistical Mechanics · Physics 2008-04-29 Kevin Leung

Continuum simulation is employed to study ion transport and fluid flow through a nanopore in a solid-state membrane under an applied potential drop. Results show the existence of concentration polarization layers on the surfaces of the…

Fluid Dynamics · Physics 2015-06-16 Mao Mao , Sandip Ghosal , Guohui Hu

With controlled ionic current rectification (ICR) achieved through a strategically designed non-uniform surface charge distribution, short unipolar nanopores exhibit promising applications in nanofluidic sensors, ionic circuits, and ion…

Chemical Physics · Physics 2025-12-08 Hongwen Zhang , Long Ma , Di Liu , Tianyi Sui , Zuzanna S. Siwy , Yinghua Qiu

We characterize the role of electrostatic fluctuations on the charge selectivity of cylindrical nanopores confining electrolyte mixtures. To this end, we develop an extended one-loop theory that can account for correlation effects induced…

Soft Condensed Matter · Physics 2014-03-05 Sahin Buyukdagli , T. Ala-Nissila

We present a modeling study of a nanopore-based transistor computed by a mean-field continuum theory (Poisson-Nernst-Planck, PNP) and a hybrid method including particle simulation (Local Equilibrium Monte Carlo, LEMC) that is able to take…

Mesoscale and Nanoscale Physics · Physics 2018-10-17 Eszter Mádai , Bartłomiej Matejczyk , András Dallos , Mónika Valiskó , Dezső Boda

With the ability to selectively control ionic flux, biological protein ion channels perform a fundamental role in many physiological processes. For practical applications that require the functionality of a biological ion channel, graphene…

We consider the translocation of a neutral (uncharged) nanoparticle through a pore in a thin membrane with constant surface charge density. If the concomitant Debye screening layer is sufficiently thin, the resulting forces experienced by…

Soft Condensed Matter · Physics 2014-01-09 Sebastian Getfert , Thomas Töws , Peter Reimann

Ion transport in highly-confined space is important to various applications, such as biosensing and seawater desalination with nanopores. All-atom molecular dynamics simulations are conducted to investigate the transport of Na$^+$ and…

Mesoscale and Nanoscale Physics · Physics 2019-07-30 Zhongwu Li , Yinghua Qiu , Yan Zhang , Min Yue , Yunfei Chen

In the present study, the ionic transport and selectivity of electrokinetically-driven flow of power-law fluids in a long pH-regulated rectangular nanochannel are analyzed. The electrical potential and momentum equations are numerically…

Fluid Dynamics · Physics 2021-11-09 Mohammad Ali Vakili , Morteza Sadeghi , Mohammad Hassan Saidi , Ali Moosavi

Liquid transport through nanopore is central into many applications, from water purification to biosensing or energy harvesting. Ultimately thin nanopores are of major interest in these applications to increase driving potential and reduce…

Fluid Dynamics · Physics 2020-10-05 Olivier Liot , Catherine Sempere , Christophe Ybert , Anne-Laure Biance

Ionic transport within charged nanopores is commonly represented by resistor-capacitor transmission line circuits, where charging electrical double layers are modeled as capacitors, and the resistance to ionic current is modeled as…

Chemical Physics · Physics 2025-05-19 Filipe Henrique , Ankur Gupta

Porous graphene has high mechanical strength and atomic layer thickness, which make it a promising material for material separation and biomolecule sensing. Electrostatic interactions between charges in aqueous solution are a kind of strong…

Chemical Physics · Physics 2016-08-02 Yinghua Qiu , Kun Li , Weiyu Chen , Wei Si , Qiyan Tan , Yunfei Chen

Ion flow in charged nanopores is strongly influenced by the ratio of the Debye length to the pore radius. We investigate the asymptotic behaviour of solutions to the Poisson-Nernst-Planck (PNP) system in narrow pore like geometries and…

Analysis of PDEs · Mathematics 2019-04-10 B. Matejczyk , J. -F. Pietschmann , G. Richardson , M. -T. Wolfram