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Mechanistic mathematical models of biological systems usually contain a number of unknown parameters whose values need to be estimated from available experimental data in order for the models to be validated and used to make quantitative…

Quantitative Methods · Quantitative Biology 2025-06-16 Yue Liu , Philip K. Maini , Ruth E. Baker

We consider the utilization of a computational model to guide the optimal acquisition of experimental data to inform the stochastic description of model input parameters. Our formulation is based on the recently developed consistent…

Computation · Statistics 2021-05-04 Scott N. Walsh , Tim M. Wildey , John D. Jakeman

Commonly used methods to analyze incomplete longitudinal clinical trial data include complete case analysis (CC) and last observation carried forward (LOCF). However, such methods rest on strong assumptions, including missing completely at…

Statistics Theory · Mathematics 2007-06-13 Ivy Jansen , Caroline Beunckens , Geert Molenberghs , Geert Verbeke , Craig Mallinckrodt

We study the problem of preferential Bayesian optimization (BO), where we aim to optimize a black-box function with only preference feedback over a pair of candidate solutions. Inspired by the likelihood ratio idea, we construct a…

Machine Learning · Computer Science 2024-05-30 Wenjie Xu , Wenbin Wang , Yuning Jiang , Bratislav Svetozarevic , Colin N. Jones

This paper is concerned with the finite sample identification performance of an n dimensional discrete-time Multiple-Input Multiple-Output (MIMO) Linear Time-Invariant system, with p inputs and m outputs. We prove that the widely-used…

Systems and Control · Electrical Eng. & Systems 2025-08-15 Shuai Sun , Jiayun Li , Yilin Mo

The well known and oft-quoted Feynman's expression, entered the title, leading at a loss and even being objectionable, has not yet a clear explanation. The hidden parameters problem in quantum mechanics is considered here on the base of…

General Physics · Physics 2017-07-11 Nicolay V. Lunin

Observational data is increasingly used as a means for making individual-level causal predictions and intervention recommendations. The foremost challenge of causal inference from observational data is hidden confounding, whose presence…

Machine Learning · Statistics 2018-10-30 Nathan Kallus , Aahlad Manas Puli , Uri Shalit

We introduce a generic estimator for the false discovery rate of any model selection procedure, in common statistical modeling settings including the Gaussian linear model, Gaussian graphical model, and model-X setting. We prove that our…

Methodology · Statistics 2026-02-25 Yixiang Luo , William Fithian , Lihua Lei

When the underlying probability distribution in a stochastic optimization is observed only through data, various data-driven formulations have been studied to obtain approximate optimal solutions. We show that no such formulations can, in a…

Optimization and Control · Mathematics 2021-05-31 Henry Lam

We present a simple derivation of a Feynman-Kac type formula to study fermionic systems. In this approach the real time or the imaginary time dynamics is expressed in terms of the evolution of a collection of Poisson processes. A computer…

Condensed Matter · Physics 2009-10-31 Matteo Beccaria , Carlo Presilla , Gian Fabrizio De Angelis , Giovanni Jona-Lasinio

Here we present a Bayesian formalism for the goodness-of-fit that is the evidence for a fixed functional form over the evidence for all functions that are a general perturbation about this form. This is done under the assumption that the…

Cosmology and Nongalactic Astrophysics · Physics 2015-07-21 T. D. Kitching , A. N. Taylor

Despite the recent success of Multimodal Large Language Models (MLLMs), existing approaches predominantly assume the availability of multiple modalities during training and inference. In practice, multimodal data is often incomplete because…

Computer Vision and Pattern Recognition · Computer Science 2026-02-20 Divyam Madaan , Sumit Chopra , Kyunghyun Cho

This letter first explores the solution uniqueness of the data-driven modeling of price-responsive flexible loads (PFL). The PFL on the demand side is critical in modern power systems. An accurate PFL model is fundamental for system…

Systems and Control · Electrical Eng. & Systems 2025-03-06 Shuai Lu , Jiayi Ding , Mingji Chen , Wei Gu , Junpeng Zhu , Yijun Xu , Zhaoyang Dong , Zezheng Sun

A mathematical model to describe period-memorizing behavior in Physarum plasmodium are reported. In constructing the model, we first examine the basic characteristics required for the class of models, then create a minimal linear model to…

Cell Behavior · Quantitative Biology 2009-05-06 Masashi Tachikawa

Statistical hypothesis testing is the central method to demarcate scientific theories in both exploratory and inferential analyses. However, whether this method befits such purpose remains a matter of debate. Established approaches to…

Data Analysis, Statistics and Probability · Physics 2024-10-29 Orestis Loukas , Ho-Ryun Chung

This note addresses a key limitation of the Folding Test of Unimodality (FTU). In specific univariate mixture settings, the folding-based criterion can systematically fail, misclassifying clearly multimodal distributions as unimodal. We…

Methodology · Statistics 2026-05-14 Colombe Becquart , Aurore Archimbaud , Anne M. Ruiz , Zaineb Smida

Consider a high-dimensional data set, in which for every data-point there is incomplete information. Each object in the data set represents a real entity, which is described by a point in high-dimensional space. We model the lack of…

Other Computer Science · Computer Science 2016-05-10 Hadassa Daltrophe , Shlomi Dolev , Zvi Lotker

Data assimilation plays a crucial role in modern weather prediction, providing a systematic way to incorporate observational data into complex dynamical models. The paper addresses continuous data assimilation for a model arising as a…

Analysis of PDEs · Mathematics 2026-02-03 Eduard Feireisl , Piotr Gwiazda , Agnieszka Świerczewska-Gwiazda

The paper presents a new statistical method that enables the use of systematic errors in the maximum-likelihood regression of integer-count Poisson data to a parametric model. The method is primarily aimed at the characterization of the…

Instrumentation and Methods for Astrophysics · Physics 2024-07-18 Max Bonamente , Yang Chen , Dale Zimmerman

Learning physical dynamics from data is a fundamental challenge in machine learning and scientific modeling. Real-world observational data are inherently incomplete and irregularly sampled, posing significant challenges for existing…

Machine Learning · Computer Science 2026-05-04 Zihan Zhou , Chenguang Wang , Hongyi Ye , Yongtao Guan , Tianshu Yu
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