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While there is a long history of employing moving boundary problems in physics, in particular via Stefan problems for heat conduction accompanied by a change of phase, more recently such approaches have been adapted to study biological…

Analysis of PDEs · Mathematics 2021-09-23 Scott W. McCue , Maud El-Hachem , Matthew J. Simpson

This review provides open-access computational tools that support a range of mathematical approaches to analyse three related scalar reaction-diffusion models used to study biological invasion. Starting with the classic Fisher-Kolmogorov…

Pattern Formation and Solitons · Physics 2024-04-26 Matthew J Simpson , Scott W McCue

The Fisher-KPP model, and generalisations thereof, is a simple reaction-diffusion models of biological invasion that assumes individuals in the population undergo linear diffusion with diffusivity $D$, and logistic proliferation with rate…

Pattern Formation and Solitons · Physics 2022-01-25 Maud El-Hachem , Scott W McCue , Matthew J Simpson

We investigate pattern formation in a two-dimensional (2D) Fisher--Stefan model, which involves solving the Fisher--KPP equation on a compactly-supported region with a moving boundary. By combining the Fisher--KPP and classical Stefan…

Biological Physics · Physics 2022-12-28 Alexander K. Y. Tam , Matthew J. Simpson

Reaction-diffusion models are often used to describe biological invasion, where populations of individuals that undergo random motility and proliferation lead to moving fronts. Many models of biological invasion are extensions of the…

Populations and Evolution · Quantitative Biology 2024-01-09 Matthew J Simpson , Nizhum Rahman , Alexander KY Tam

Single-species reaction-diffusion equations, such as the Fisher-KPP and Porous-Fisher equations, support travelling wave solutions that are often interpreted as simple mathematical models of biological invasion. Such travelling wave…

Tissues and Organs · Quantitative Biology 2021-10-04 Maud El-Hachem , Scott W McCue , Matthew J Simpson

We analyse a novel mathematical model of malignant invasion which takes the form of a two-phase moving boundary problem describing the invasion of a population of malignant cells into a population of background tissue, such as skin. Cells…

Pattern Formation and Solitons · Physics 2020-09-04 Maud El-Hachem , Scott W McCue , Matthew J Simpson

The Fisher-Stefan model involves solving the Fisher-KPP equation on a domain whose boundary evolves according to a Stefan-like condition. The Fisher-Stefan model alleviates two practical limitations of the standard Fisher-KPP model when…

Biological Physics · Physics 2022-06-22 Alexander K. Y. Tam , Matthew J. Simpson

Invasion waves are a fundamental building block of theoretical ecology. In this study we aim to take the first steps to link propagation failure and fast acceleration of traveling waves to critical transitions (or tipping points). The…

Populations and Evolution · Quantitative Biology 2015-03-06 Christian Kuehn

We consider a minimal go-or-grow model of cell invasion, whereby cells can either proliferate, following logistic growth, or move, via linear diffusion, and phenotypic switching between these two states is density-dependent. Formal analysis…

Analysis of PDEs · Mathematics 2024-04-18 Carles Falcó , Rebecca M. Crossley , Ruth E. Baker

The famous Fisher-KPP reaction-diffusion model combines linear diffusion with the typical KPP reaction term, and appears in a number of relevant applications in biology and chemistry. It is remarkable as a mathematical model since it…

Analysis of PDEs · Mathematics 2016-02-19 Alessandro Audrito , Juan Luis Vázquez

In this paper, we propose a novel free boundary problem to model the movement of single species with a range boundary. The spatial movement and birth/death processes of the species found within the range boundary are assumed to be governed…

Analysis of PDEs · Mathematics 2022-01-13 Chunxi Feng , Mark A. Lewis , Chuncheng Wang , Hao Wang

We consider a moving boundary mathematical model of biological invasion. The model describes the spatiotemporal evolution of two adjacent populations: each population undergoes linear diffusion and logistic growth, and the boundary between…

Populations and Evolution · Quantitative Biology 2023-09-06 Matthew J Simpson , Nizhum Rahman , Scott W McCue , Alexander KY Tam

We consider a Fisher-KPP-type equation, where both diffusion and nonlinear part are nonlocal, with anisotropic probability kernels. Under minimal conditions on the coefficients, we prove existence, uniqueness, and uniform space-time…

Analysis of PDEs · Mathematics 2015-09-22 Dmitri Finkelshtein , Yuri Kondratiev , Pasha Tkachov

Non-cooperative Fisher-KPP systems with space-time periodic coefficients are motivated for instance by models for structured populations evolving in periodic environments. This paper is concerned with entire solutions describing the…

Analysis of PDEs · Mathematics 2026-02-09 Léo Girardin , Grégoire Nadin

A family of travelling wave solutions to the Fisher-KPP equation with speeds $c=\pm 5/\sqrt{6}$ can be expressed exactly using Weierstrass elliptic functions. The well-known solution for $c=5/\sqrt{6}$, which decays to zero in the…

Pattern Formation and Solitons · Physics 2021-09-24 Scott W McCue , Maud El-Hachem , Matthew J Simpson

We perform the analysis of a hyperbolic model which is the analog of the Fisher-KPP equation. This model accounts for particles that move at maximal speed $\epsilon^{-1}$ ($\epsilon\textgreater{}0$), and proliferate according to a reaction…

Analysis of PDEs · Mathematics 2016-11-22 Emeric Bouin , Vincent Calvez , Grégoire Nadin

In this paper, we treat the Fisher-KPP equation with a Caputo-type time fractional derivative and discuss the propagation speed of the solution. The equation is a mathematical model that describes the processes of sub-diffusion,…

Analysis of PDEs · Mathematics 2026-01-21 Hiroshi Ishii

We examine the effect of a slowly-varying time-dependent parameter on invasion fronts for which an unstable homogeneous equilibrium is invaded by either another homogeneous state or a spatially periodic state. We first explain and motivate…

Pattern Formation and Solitons · Physics 2025-06-17 Montie Avery , Odalys Garcia-Lopez , Ryan Goh , Benjamin Hosek , Ethan Shade

We consider a two-component reaction-diffusion system that has previously been developed to model invasion of cells into a resident cell population. The system is an idealised version of models of tumour growth in which tumour cells degrade…

Analysis of PDEs · Mathematics 2025-12-16 Yuhui Chen , Michael C. Dallaston
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