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Due to rapidly rising healthcare costs worldwide, there is significant interest in controlling them. An important aspect concerns price transparency, as preliminary efforts have demonstrated that patients will shop for lower costs, driving…
We develop a prediction-based prescriptive model for learning optimal personalized treatments for patients based on their Electronic Health Records (EHRs). Our approach consists of: (i) predicting future outcomes under each possible therapy…
This paper presents a novel deep learning enabled, video based analysis framework for assessing the Unified Parkinsons Disease Rating Scale (UPDRS) that can be used in the clinic or at home. We report results from comparing the performance…
We study the behavior of a Time-Aware Long Short-Term Memory Autoencoder, a state-of-the-art method, in the context of learning latent representations from irregularly sampled patient data. We identify a key issue in the way such recurrent…
Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide and affects around 1% of the (60+ years old) elderly population in industrial nations. More than 80% of PD patients suffer from motor symptoms, which…
Purpose: A fast data-driven optimization approach, named bias-accelerated subset selection (BASS), is proposed for learning efficacious sampling patterns (SPs) with the purpose of reducing scan time in large-dimensional parallel MRI.…
Parkinson's disease (PD) is the most widespread movement condition and the second most common neurodegenerative disorder, following Alzheimer's. Movement symptoms and imaging techniques are the most popular ways to diagnose this disease.…
The stage and severity of Parkinson's disease (PD) is an important factor to consider for taking effective therapeutic decisions. Although the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) provides an…
Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common neurodegenerative disorders in humans. Because a significant percentage of patients have clinical and pathological features of both diseases, it has been…
The development of effective treatments for Cerebral Palsy (CP) can begin with the early identification of affected children while they are still in the early stages of the disorder. Pathological issues in the brain can be better diagnosed…
Sequential recommender systems have become increasingly important in real-world applications that model user behavior sequences to predict their preferences. However, existing sequential recommendation methods predominantly rely on…
We introduce a Reinforcement Learning Psychotherapy AI Companion that generates topic recommendations for therapists based on patient responses. The system uses Deep Reinforcement Learning (DRL) to generate multi-objective policies for four…
Parkinson's disease (PD) affects over ten million people worldwide. Although temporal interference (TI) and deep brain stimulation (DBS) are promising therapies, inter-individual variability limits empirical treatment selection, increasing…
Parkinson's Disease (PD) is one of the most common types of neurological diseases caused by progressive degeneration of dopamin- ergic neurons in the brain. Even though there is no fixed cure for this neurodegenerative disease, earlier…
Disease prediction holds considerable significance in modern healthcare, because of its crucial role in facilitating early intervention and implementing effective prevention measures. However, most recent disease prediction approaches…
Background. Alzheimer's disease and related dementia (ADRD) are characterized by multiple and progressive anatomo clinical changes. Yet, modeling changes over disease course from cohort data is challenging as the usual timescales are…
This paper presents a method for building patient-based networks that we call Precision disease networks, and its uses for predicting medical outcomes. Our methodology consists of building networks, one for each patient or case, that…
In 2023, the U.S. Food and Drug Administration issued guidance for adjustment of covariates in randomized clinical trials, emphasizing its role in enhancing precision and power through prognostic baseline variables. Despite its potential,…
Computer aided diagnosis systems can provide non-invasive, low-cost tools to support clinicians. These systems have the potential to assist the diagnosis and monitoring of neurodegenerative disorders, in particular Parkinson's disease (PD).…
Large language models (LLMs) have demonstrated notable potential in medical applications, yet they face substantial challenges in handling complex real-world clinical diagnoses using conventional prompting methods. Current prompt…