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Chronic diseases and cancer account for over 75 percent of healthcare costs in the US. Increased prevention services and improved primary care are thought to decrease costs. Current models for detecting changes in the health of populations…

Populations and Evolution · Quantitative Biology 2013-07-15 Jacob Kuriyan , Nathaniel Cobb

This paper analyzes mortality cohort effect of birth year and develops an approach to identify and measure cohort effects in mortality data set. The approach is based on differential geometry and leads to an explicit result which can…

Applications · Statistics 2015-04-03 Ning Zhang , Liang Zhao

This article investigates crime patterns across European countries in 2022 using Compositional Data Analysis (CoDA) to address limitations of traditional statistical approaches in dealing with the relative nature of crime data. Recognizing…

Applications · Statistics 2025-02-18 Onur Batın Doğan , Fatma Sevinç Kurnaz

This paper introduces new methods to study the changing dynamics of COVID-19 cases and deaths among the 50 worst-affected countries throughout 2020. First, we analyse the trajectories and turning points of rolling mortality rates to…

Physics and Society · Physics 2021-06-15 Nick James , Max Menzies

To explore the mechanistic relationships between ageing, frailty and mortality, we developed a computational model in which possible health attributes are represented by the nodes of a complex network. Each node can be either damaged (i.e.…

Populations and Evolution · Quantitative Biology 2017-06-30 Andrew D. Rutenberg , Arnold B. Mitnitski , Spencer Farrell , Kenneth Rockwood

The illness-death model of a chronic disease consists of the states 'Normal', 'Disease' and 'Death'. In general, the transition rates between the states depend on three time scales: calendar time, age and duration of the chronic disease.…

Populations and Evolution · Quantitative Biology 2013-08-30 Ralph Brinks

Density dependence is important in the ecology and evolution of microbial and cancer cells. Typically, we can only measure net growth rates, but the underlying density-dependent mechanisms that give rise to the observed dynamics can…

Populations and Evolution · Quantitative Biology 2025-06-04 Linh Huynh , Jacob G. Scott , Peter J. Thomas

Understanding and modeling mortality patterns, especially differences in mortality rates between populations, is vital for demographic analysis and public health planning. We compare three statistical models within the age-period framework…

Applications · Statistics 2025-10-14 Giacomo Lanfiuti Baldi , Andrea Nigri , Han Lin Shang

Death events commonly arise from complex interactions among interrelated causes, formally classified in reporting practices as underlying and contributing. Leveraging information from death certificates, these interactions can be naturally…

Applications · Statistics 2025-10-03 Giovanni Romanò , Cristian Castiglione , Daniele Durante

Over the last decades, many prognostic models based on artificial intelligence techniques have been used to provide detailed predictions in healthcare. Unfortunately, the real-world observational data used to train and validate these models…

Machine Learning · Computer Science 2023-11-21 Alice Bernasconi , Alessio Zanga , Peter J. F. Lucas , Marco Scutari , Fabio Stella

Forecasts of mortality provide vital information about future populations, with implications for pension and health-care policy as well as for decisions made by private companies about life insurance and annuity pricing. Stochastic…

Applications · Statistics 2018-06-21 Jason Hilton , Erengul Dodd , Jonathan J. Forster , Peter W. F. Smith

Complex systems research is becomingly increasingly data-driven, particularly in the social and biological domains. Many of the systems from which sample data are collected feature structural heterogeneity at the mesoscopic scale (i.e.…

Physics and Society · Physics 2009-11-13 Jukka-Pekka Onnela , Neil F. Johnson , Sean Gourley , Gesine Reinert , Michael Spagat

This article describes a method to estimate the mortality rate ratio R from current status data with duration in a chronic condition in case the general mortality of the overall population is known. Apart from the general mortality, the…

Methodology · Statistics 2022-10-21 Ralph Brinks

A set of curves or images of similar shape is an increasingly common functional data set collected in the sciences. Principal Component Analysis (PCA) is the most widely used technique to decompose variation in functional data. However, the…

Methodology · Statistics 2009-09-29 Rima Izem , J. S. Marron

Panel count data arise from longitudinal studies on recurrent events where each subject is observed only at discrete time points. If recurrent events of several types are possible, we obtain panel count data with multiple modes of…

Methodology · Statistics 2021-06-04 Sankaran P. G. , Ashlin Mathew P. M. , Sreedevi E. P

A data table which is arranged according to two factors can often be considered as a compositional table. An example is the number of unemployed people, split according to gender and age classes. Analyzed as compositions, the relevant…

Methodology · Statistics 2019-04-12 Julie Rendlová , Karel Hron , Kamila Fačevicová , Peter Filzmoser

We investigate patterns of COVID-19 mortality across 20 Italian regions and their association with mobility, positivity, and socio-demographic, infrastructural and environmental covariates. Notwithstanding limitations in accuracy and…

Applications · Statistics 2021-09-29 Tobia Boschi , Jacopo Di Iorio , Lorenzo Testa , Marzia A. Cremona , Francesca Chiaromonte

Nowadays data sets are available in very complex and heterogeneous ways. Mining of such data collections is essential to support many real-world applications ranging from healthcare to marketing. In this work, we focus on the analysis of…

Artificial Intelligence · Computer Science 2015-04-10 Aleksey Buzmakov , Elias Egho , Nicolas Jay , Sergei O. Kuznetsov , Amedeo Napoli , Chedy Raïssi

Using the economic complexity methodology on data for disease prevalence in 195 countries during the period of 1990-2016, we propose two new metrics for quantifying the relatedness between diseases, or the `disease space' of countries. With…

Physics and Society · Physics 2019-03-26 Antonios Garas , Sophie Guthmuller , Athanasios Lapatinas

Many scientific datasets are compositional in nature. Important biological examples include species abundances in ecology, cell-type compositions derived from single-cell sequencing data, and amplicon abundance data in microbiome research.…

Machine Learning · Computer Science 2024-05-29 Elisabeth Ailer , Christian L. Müller , Niki Kilbertus
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