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Knockoffs is a new framework for controlling the false discovery rate (FDR) in multiple hypothesis testing problems involving complex statistical models. While there has been great emphasis on Type-I error control, Type-II errors have been…

Methodology · Statistics 2017-12-19 Asaf Weinstein , Rina Barber , Emmanuel Candes

The Lasso is one of the most ubiquitous methods for variable selection in high-dimensional linear regression and has been studied extensively under different regimes. In a particular asymptotic setup entailing $n/p\to \text{constant}$, an…

Statistics Theory · Mathematics 2026-02-10 Lina Hidmi , Asaf Weinstein

Model-X knockoffs is a general procedure that can leverage any feature importance measure to produce a variable selection algorithm, which discovers true effects while rigorously controlling the number or fraction of false positives.…

Methodology · Statistics 2020-12-07 Zhimei Ren , Yuting Wei , Emmanuel Candès

Many contemporary large-scale applications involve building interpretable models linking a large set of potential covariates to a response in a nonlinear fashion, such as when the response is binary. Although this modeling problem has been…

Methodology · Statistics 2017-12-13 Emmanuel Candes , Yingying Fan , Lucas Janson , Jinchi Lv

In many scientific problems, researchers try to relate a response variable $Y$ to a set of potential explanatory variables $X = (X_1,\dots,X_p)$, and start by trying to identify variables that contribute to this relationship. In statistical…

Statistics Theory · Mathematics 2020-10-07 Wenshuo Wang , Lucas Janson

Model-X knockoffs allows analysts to perform feature selection using almost any machine learning algorithm while still provably controlling the expected proportion of false discoveries. To apply model-X knockoffs, one must construct…

Methodology · Statistics 2021-06-30 Asher Spector , Lucas Janson

Model-X knockoffs is a wrapper that transforms essentially any feature importance measure into a variable selection algorithm, which discovers true effects while rigorously controlling the expected fraction of false positives. A frequently…

Methodology · Statistics 2024-03-12 Stephen Bates , Emmanuel Candès , Lucas Janson , Wenshuo Wang

We consider the variable selection problem, which seeks to identify important variables influencing a response $Y$ out of many candidate features $X_1, \ldots, X_p$. We wish to do so while offering finite-sample guarantees about the…

Methodology · Statistics 2019-02-12 Rina Foygel Barber , Emmanuel J. Candès , Richard J. Samworth

We investigate the robustness of the model-X knockoffs framework with respect to the misspecified or estimated feature distribution. We achieve such a goal by theoretically studying the feature selection performance of a practically…

Methodology · Statistics 2024-06-06 Yingying Fan , Lan Gao , Jinchi Lv

This paper introduces a machine for sampling approximate model-X knockoffs for arbitrary and unspecified data distributions using deep generative models. The main idea is to iteratively refine a knockoff sampling mechanism until a criterion…

Methodology · Statistics 2020-03-03 Yaniv Romano , Matteo Sesia , Emmanuel J. Candès

Recently, the scheme of model-X knockoffs was proposed as a promising solution to address controlled feature selection under high-dimensional finite-sample settings. However, the procedure of model-X knockoffs depends heavily on the…

Methodology · Statistics 2022-03-10 Xuebin Zhao , Hong Chen , Yingjie Wang , Weifu Li , Tieliang Gong , Yulong Wang , Feng Zheng

The recent paper Cand\`es et al. (2018) introduced model-X knockoffs, a method for variable selection that provably and non-asymptotically controls the false discovery rate with no restrictions or assumptions on the dimensionality of the…

Methodology · Statistics 2020-06-16 Dongming Huang , Lucas Janson

Although there is a huge literature on feature selection for the Cox model, none of the existing approaches can control the false discovery rate (FDR) unless the sample size tends to infinity. In addition, there is no formal power analysis…

Methodology · Statistics 2023-08-02 Daoji Li , Jinzhao Yu , Hui Zhao

Maximizing statistical power in experimental design often involves imbalanced treatment allocation, but several challenges hinder its practical adoption: (1) the misconception that equal allocation always maximizes power, (2) when only…

Methodology · Statistics 2025-09-17 Stef Baas , Lukas Pin , Sofía S. Villar , William F. Rosenberger

The model-X conditional randomization test is a generic framework for conditional independence testing, unlocking new possibilities to discover features that are conditionally associated with a response of interest while controlling type-I…

Machine Learning · Computer Science 2023-02-21 Shalev Shaer , Yaniv Romano

The Model-X knockoff procedure has recently emerged as a powerful approach for feature selection with statistical guarantees. The advantage of knockoff is that if we have a good model of the features X, then we can identify salient features…

Machine Learning · Statistics 2019-05-30 Jaime Roquero Gimenez , James Zou

Linear mixed-effects models have increasingly replaced mixed-model analyses of variance for statistical inference in factorial psycholinguistic experiments. Although LMMs have many advantages over ANOVA, like ANOVAs, setting them up for…

Applications · Statistics 2017-02-14 Hannes Matuschek , Reinhold Kliegl , Shravan Vasishth , Harald Baayen , Douglas Bates

The knockoff filter is a recent false discovery rate (FDR) control method for high-dimensional linear models. We point out that knockoff has three key components: ranking algorithm, augmented design, and symmetric statistic, and each…

Statistics Theory · Mathematics 2024-02-14 Zheng Tracy Ke , Jun S. Liu , Yucong Ma

In feature selection problems, knockoffs are synthetic controls for the original features. Employing knockoffs allows analysts to use nearly any variable importance measure or "feature statistic" to select features while rigorously…

Methodology · Statistics 2024-10-02 Asher Spector , William Fithian

We describe a series of algorithms that efficiently implement Gaussian model-X knockoffs to control the false discovery rate on large scale feature selection problems. Identifying the knockoff distribution requires solving a large scale…

Machine Learning · Computer Science 2020-06-17 Armin Askari , Quentin Rebjock , Alexandre d'Aspremont , Laurent El Ghaoui
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