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In clinical trials, mixed effects models for repeated measures (MMRM) and pattern mixture models (PMM) are often used to analyze longitudinal continuous outcomes. We describe a simple missing data imputation algorithm for the MMRM that can…

Methodology · Statistics 2016-10-13 Yongqiang Tang

Randomization inference is a widely-used and appealing approach for analyzing treatment effects in randomized experiments, as it is finite-sample valid and does not require any distributional assumptions. However, naive application of…

Econometrics · Economics 2026-05-12 Xinran Li , Peizan Sheng , Zeyang Yu

Non-Gaussian outcomes are often modeled using members of the so-called exponential family. Notorious members are the Bernoulli model for binary data, leading to logistic regression, and the Poisson model for count data, leading to Poisson…

The problem of modeling the relationship between univariate distributions and one or more explanatory variables has found increasing interest. Traditional functional data methods cannot be applied directly to distributional data because of…

Methodology · Statistics 2025-02-04 Yidong Zhou , Hans-Georg Müller

Imputation is a popular technique for handling item nonresponse in survey sampling. Parametric imputation is based on a parametric model for imputation and is less robust against the failure of the imputation model. Nonparametric imputation…

Methodology · Statistics 2019-09-20 Danhyang Lee , Jae Kwang Kim

Imputation is a popular technique for handling missing data. We consider a nonparametric approach to imputation using the kernel ridge regression technique and propose consistent variance estimation. The proposed variance estimator is based…

Methodology · Statistics 2021-02-02 Hengfang Wang , Jae-Kwang Kim

This paper provides clear and practical guidance on the specification of imputation models when multiple imputation is used in conjunction with doubly robust estimation methods for causal inference. Through theoretical arguments and…

Methodology · Statistics 2025-12-19 Lucy D'Agostino McGowan

We compare two deletion-based methods for dealing with the problem of missing observations in linear regression analysis. One is the complete-case analysis (CC, or listwise deletion) that discards all incomplete observations and only uses…

Methodology · Statistics 2023-05-02 Tianchen Xu , Kun Chen , Gen Li

Missing data imputation forms the first critical step of many data analysis pipelines. The challenge is greatest for mixed data sets, including real, Boolean, and ordinal data, where standard techniques for imputation fail basic sanity…

Methodology · Statistics 2020-06-17 Yuxuan Zhao , Madeleine Udell

Missing data imputation is an important research topic in data mining. Large-scale Molecular descriptor data may contains missing values (MVs). However, some methods for downstream analyses, including some prediction tools, require a…

Computational Engineering, Finance, and Science · Computer Science 2013-12-13 Doreswamy , Chanabasayya . M. Vastrad

For many use cases, combining information from different datasets can be of interest to improve a machine learning model's performance, especially when the number of samples from at least one of the datasets is small. However, a potential…

Machine Learning · Statistics 2023-05-17 Thu Nguyen , Rabindra Khadka , Nhan Phan , Anis Yazidi , Pål Halvorsen , Michael A. Riegler

Multiple imputation (MI) has become popular for analyses with missing data in medical research. The standard implementation of MI is based on the assumption of data being missing at random (MAR). However, for missing data generated by…

Methodology · Statistics 2019-01-03 Tra My Pham , James R Carpenter , Tim P Morris , Angela M Wood , Irene Petersen

Imputation methods for dealing with incomplete data typically assume that the missingness mechanism is at random (MAR). These methods can also be applied to missing not at random (MNAR) situations, where the user specifies some adjustment…

Methodology · Statistics 2024-04-24 Shahab Jolani , Stef van Buuren

Missing value is a very common and unavoidable problem in sensors, and researchers have made numerous attempts for missing value imputation, particularly in deep learning models. However, for real sensor data, the specific data distribution…

Machine Learning · Computer Science 2022-09-27 JinSheng Yang , YuanHai Shao , ChunNa Li , Wensi Wang

Accurate imputation is essential for the reliability and success of downstream tasks. Recently, diffusion models have attracted great attention in this field. However, these models neglect the latent distribution in a lower-dimensional…

Machine Learning · Computer Science 2024-09-16 Guojun Liang , Najmeh Abiri , Atiye Sadat Hashemi , Jens Lundström , Stefan Byttner , Prayag Tiwari

Clinical prediction models must be developed using sufficiently large datasets to minimise overfitting and ensure robust predictive performance. Existing sample size calculations assume complete predictor data for all included participants,…

Although models for count data with over-dispersion have been widely considered in the literature, models for under-dispersion -- the opposite phenomenon -- have received less attention as it is only relatively common in particular research…

Bayesian models that can handle both over and under dispersed counts are rare in the literature, perhaps because full probability distributions for dispersed counts are rather difficult to construct. This note takes a first look at Bayesian…

Methodology · Statistics 2020-10-08 Alan Huang , Andy Sang Il Kim

Missing data is a ubiquitous challenge in data analysis, often leading to biased and inaccurate results. Traditional imputation methods usually assume that the missingness mechanism is missing-at-random (MAR), where the missingness is…

Methodology · Statistics 2026-03-30 Huiming Xie , Fei Xue , Xiao Wang

Classical semiparametric inference with missing outcome data is not robust to contamination of the observed data and a single observation can have arbitrarily large influence on estimation of a parameter of interest. This sensitivity is…

Methodology · Statistics 2021-03-02 Eva Cantoni , Xavier de Luna
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