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Upon hydrogen bond formation, electronic charge density is transferred between the donor and acceptor, impacting processes ranging from hydration to spectroscopy. Here we use ab initio path integral simulations to elucidate the role of…

Chemical Physics · Physics 2018-11-28 Christoph Schran , Ondrej Marsalek , Thomas E. Markland

Hydrogen bonds play a pivotal role in chemistry, biology, and condensed-matter physics, where quantum tunnelling can strongly influence structure and dynamics. Isotope substitution (H $\rightarrow$ D) provides a sensitive probe of such…

Chemical Physics · Physics 2025-11-05 Krishna Kingkar Pathak

Enzymes utilize protein architectures to create highly specialized structural motifs that can greatly enhance the rates of complex chemical transformations. Here we use experiments, combined with ab initio simulations that exactly include…

Chemical Physics · Physics 2015-01-05 Lu Wang , Stephen D. Fried , Steven G. Boxer , Thomas E. Markland

Hydrogen is the most abundant element in the universe. It is also the lightest and as such the most quantum of the elements, in the sense that quantum tunnelling, quantum delocalisation, and zero-point motion can be important. For practical…

Chemical Physics · Physics 2019-01-18 Wei Fang , Ji Chen , Yexin Feng , Xin-Zheng Li , Angelos Michaelides

Nuclear quantum effects of protons on electronic excitations in hydrogen-bonded organic materials remains underexplored. In theoretical studies, modeling excitons in these extended systems is particularly difficult because they tend to have…

Materials Science · Physics 2026-02-10 Sampreeti Bhattacharya , Jianhang Xu , Ruiyi Zhou , Yosuke Kanai

This work considers how the properties of hydrogen bonded complexes, D-H....A, are modified by the quantum motion of the shared proton. Using a simple two-diabatic state model Hamiltonian, the analysis of the symmetric case, where the donor…

Chemical Physics · Physics 2014-05-09 Ross H. McKenzie , Christiaan Bekker , Bijyalaxmi Athokpam , Sai G. Ramesh

Using first-principles molecular dynamics, we study the influence of nuclear quantum effects (NQEs) and nonlocal exchange--correlation density functionals (DFs) near molecular dissociation in liquid hydrogen. NQEs strongly influence…

Materials Science · Physics 2013-03-28 M. A. Morales , J. M. McMahon , C. Pierleoni , D. M. Ceperley

Quantum proton tunneling (QPT) in the two representative multi-electron/-proton transfer electrode processes, i.e. hydrogen evolution reaction (HER) and oxygen reduction reaction (ORR), was investigated by using polycrystalline platinum…

Chemical Physics · Physics 2019-07-02 Ken Sakaushi

The role of proton tunneling in biological catalysis is investigated here within the frameworks of quantum information theory and thermodynamics. We consider the quantum correlations generated through two hydrogen bonds between a substrate…

Chemical Physics · Physics 2018-10-04 Onur Pusuluk , Tristan Farrow , Cemsinan Deliduman , Keith Burnett , Vlatko Vedral

Based on an accurate first principles description of the energetics in H-bonded KDP, we conduct a first study of nuclear quantum effects and of the changes brought about by deuteration. Cluster tunneling involving also heavy ions is…

Materials Science · Physics 2009-11-07 S. Koval , J. Kohanoff , R. L. Migoni , E. Tosatti

One of the most important topics in molecular biology is the genetic stability of DNA. One threat to this stability is proton transfer along the hydrogen bonds of DNA that could lead to tautomerisation, hence creating point mutations. We…

Biological Physics · Physics 2021-10-04 Louie Slocombe , Marco Sacchi , Jim Al-Khalili

Ab initio simulations that account for nuclear quantum effects have been used to examine the order-disorder transition in squaric acid, a prototypical H-bonded antiferroelectric crystal. Our simulations reproduce the >100 K difference in…

Materials Science · Physics 2015-06-18 K. T. Wikfeldt , A. Michaelides

The influence of an intramolecular proton transfer reaction on the conductance of a molecular junction is investigated employing a generic model, which includes the effects of the electric field of the gate and leads electrodes and the…

Mesoscale and Nanoscale Physics · Physics 2017-03-08 Chriszandro Hofmeister , Pedro B. Coto , Michael Thoss

The electronic properties and optical response of ice and water are intricately shaped by their molecular structure, including the quantum mechanical nature of hydrogen atoms. In spite of numerous studies appeared over decades, a…

Nuclear quantum effects (NQEs) on the structures and transport properties of dense liquid hydrogen at densities of 10-100 g/cm3 and temperatures of 0.1-1 eV are fully assessed using \textit{ab initio} path-integral molecular dynamics…

Materials Science · Physics 2019-12-10 Dongdong Kang , Huayang Sun , Jiayu Dai , Zengxiu Zhao , Yong Hou , Jiaolong Zeng , Jianmin Yuan

We investigate the impact of the quantum effects of protons on the electronic structure of high-pressure H$_3$S, a benchmark hydrogen-rich superconductor with a critical temperature ($T_c$) exceeding 200 K. Using Nuclear-Electronic Orbital…

Computational Physics · Physics 2026-04-07 Jianhang Xu , Aaron M. Schankler , Yosuke Kanai

Hydrogen bond networks play vital roles in biological functions ranging from protein folding to enzyme catalysis. Here we combine electronic structure calculations and ab initio path integral molecular dynamics simulations, which…

Biological Physics · Physics 2017-08-17 Lu Wang , Stephen D. Fried , Thomas E. Markland

Hydrogen bonds are of paramount importance in the chemistry of clays, mediating the interaction between the clay surface and water, and for some materials between separate layers. It is well-established that the accuracy of a computational…

Chemical Physics · Physics 2022-03-14 Pawan J. K. Kurapothula , Sam Shepherd , David M. Wilkins

Nuclear quantum effects, such as zero-point energy and tunneling, cause significant changes to the structure and dynamics of hydrogen bonded systems such as liquid water. However, due to the current inability to simulate liquid water using…

Chemical Physics · Physics 2015-06-19 Lu Wang , Michele Ceriotti , Thomas E. Markland

Electronically excited atoms or molecules in an environment are often subject to interatomic/intermolecular Coulombic decay (ICD) and/or electron transfer mediated decay (ETMD) mechanisms. A few of the numerous variables that can impact…

Chemical Physics · Physics 2022-09-15 Ravi Kumar , Dr. Nayana Vaval
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