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More and more observational studies exploit the achievements of mobile technology to ease the overall implementation procedure. Many strategies like digital phenotyping, ecological momentary assessments or mobile crowdsensing are used in…

Other Computer Science · Computer Science 2021-07-30 Carsten Vogel , Johannes Schobel , Winfried Schlee , Milena Engelke , Rüdiger Pryss

Mixed Models for Repeated Measures (MMRMs) are ubiquitous when analyzing outcomes of clinical trials. However, the linearity of the fixed-effect structure in these models largely restrict their use to estimating treatment effects that are…

Methodology · Statistics 2023-01-23 Lars Lau Raket

Dynamic treatment regimes (DTRs) are sequences of decision rules that recommend treatments based on patients' time-varying clinical conditions. The sequential multiple assignment randomized trial (SMART) is an experimental design that can…

Methodology · Statistics 2024-05-14 Xinru Wang , Nina Deliu , Yusuke Narita , Bibhas Chakraborty

Mental health issues significantly impact individuals' daily lives, yet many do not receive the help they need even with available online resources. This study aims to provide accessible, stigma-free, personalized, and real-time mental…

Human-Computer Interaction · Computer Science 2025-09-23 Qiming Guo , Jinwen Tang , Wenbo Sun , Haoteng Tang , Yi Shang , Wenlu Wang

Dynamic treatment regimens (DTRs), also known as treatment algorithms or adaptive interventions, play an increasingly important role in many health domains. DTRs are motivated to address the unique and changing needs of individuals by…

Problematic smartphone use negatively affects physical and mental health. Despite the wide range of prior research, existing persuasive techniques are not flexible enough to provide dynamic persuasion content based on users' physical…

Computation and Language · Computer Science 2024-02-29 Ruolan Wu , Chun Yu , Xiaole Pan , Yujia Liu , Ningning Zhang , Yue Fu , Yuhan Wang , Zhi Zheng , Li Chen , Qiaolei Jiang , Xuhai Xu , Yuanchun Shi

The ubiquitous nature of mobile health (mHealth) technology has expanded opportunities for the integration of reinforcement learning into traditional clinical trial designs, allowing researchers to learn individualized treatment policies…

The field of Artificial Intelligence has witnessed remarkable progress in recent years, especially with the emergence of powerful large language models (LLMs) based on the transformer architecture. Cloud-based LLMs, such as OpenAI's…

Computation and Language · Computer Science 2023-10-04 Samuel Carreira , Tomás Marques , José Ribeiro , Carlos Grilo

In clinical trials, response-adaptive randomization (RAR) has the appealing ability to assign more subjects to better-performing treatments based on interim results. The traditional RAR strategy alters the randomization ratio on a…

Methodology · Statistics 2021-10-01 David Merrell , Thevaa Chandereng , Yeonhee Park

Randomised Controlled Trials (RCTs) are the gold standard for estimating treatment effects across many fields of science. Technology companies have adopted A/B-testing methods as a modern RCT counterpart, where end-users are randomly…

Social and Information Networks · Computer Science 2024-09-20 Olivier Jeunen

Micro-randomized trials (MRTs) have become increasingly popular for developing and evaluating mobile health interventions that promote healthy behaviors and manage chronic conditions. The recently proposed causal excursion effects have…

Methodology · Statistics 2025-09-26 Jiaxin Yu , Tianchen Qian

Personalized intervention strategies, in particular those that modify treatment based on a participant's own response, are a core component of precision medicine approaches. Sequential Multiple Assignment Randomized Trials (SMARTs) are…

Machine learning (ML) models are increasingly used as decision-support tools in high-risk domains. Evaluating the causal impact of deploying such models can be done with a randomized controlled trial (RCT) that randomizes users to ML vs.…

Methodology · Statistics 2025-07-17 Jacob M. Chen , Michael Oberst

The automated generation of hardware register-transfer level (RTL) code with large language models (LLMs) shows promise, yet current solutions struggle to produce syntactically and functionally correct code for complex digital designs. This…

Software Engineering · Computer Science 2026-01-21 Nowfel Mashnoor , Mohammad Akyash , Hadi Kamali , Kimia Azar

We propose an incentive scheme based on intervention to sustain cooperation among self-interested users. In the proposed scheme, an intervention device collects imperfect signals about the actions of the users for a test period, and then…

Computer Science and Game Theory · Computer Science 2010-12-09 Jaeok Park , Mihaela van der Schaar

Cluster-randomized trials (CRTs) involve randomizing entire groups of participants -- called clusters -- to treatment arms but are often comprised of a limited or fixed number of available clusters. While covariate adjustment can account…

Methodology · Statistics 2022-11-29 Angela Y. Zhu , Nandita Mitra , Karla Hemming , Michael O. Harhay , Fan Li

Over the last decade, there has been significant progress in the field of interactive virtual rehabilitation. Physical therapy (PT) stands as a highly effective approach for enhancing physical impairments. However, patient motivation and…

Human-Computer Interaction · Computer Science 2024-05-24 Pavan Uttej Ravva , Pinar Kullu , Mohammad Fahim Abrar , Roghayeh Leila Barmaki

Recent advances in robotics have been largely driven by imitation learning, which depends critically on large-scale, high-quality demonstration data. However, collecting such data remains a significant challenge-particularly for mobile…

Robotics · Computer Science 2025-10-07 Yilin Mei , Peng Qiu , Wei Zhang , WenChao Zhang , Wenjie Song

Timely decision making is critical to the effectiveness of mobile health (mHealth) interventions. At predefined timepoints called "decision points," intelligent mHealth systems such as just-in-time adaptive interventions (JITAIs) estimate…

Artificial Intelligence · Computer Science 2025-09-16 Asim H. Gazi , Bhanu Teja Gullapalli , Daiqi Gao , Benjamin M. Marlin , Vivek Shetty , Susan A. Murphy

Randomized clinical trials are considered the gold standard for estimating causal effects. Nevertheless, in studies that are aimed at examining adverse effects of interventions, such trials are often impractical because of ethical and…

Methodology · Statistics 2020-01-20 Anthony D. Scotina , Andrew R. Zullo , Robert J. Smith , Roee Gutman
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