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Increasing technological sophistication and widespread use of smartphones and wearable devices provide opportunities for innovative and highly personalized health interventions. A Just-In-Time Adaptive Intervention (JITAI) uses real-time…

Machine Learning · Statistics 2022-04-26 Huitian Lei , Yangyi Lu , Ambuj Tewari , Susan A. Murphy

Recently a new experimental approach, the hybrid experimental design (HED), was introduced to enable investigators to answer scientific questions about building behavioral interventions in which human-delivered and digital components are…

Methodology · Statistics 2026-02-26 Mengbing Li , Inbal Nahum-Shani , Walter Dempsey

Contextual sensing and delivery of digital interventions to improve health outcomes have gained significant traction in behavioral and psychiatric studies. Micro-randomized trials (MRTs) are a common experimental design for obtaining…

Methodology · Statistics 2025-04-01 Jieru Shi , Zhenke Wu , Walter Dempsey

Cluster-level dynamic treatment regimens can be used to guide sequential, intervention or treatment decision-making at the cluster level in order to improve outcomes at the individual or patient-level. In a cluster-level DTR, the…

Methodology · Statistics 2016-07-15 Timothy NeCamp , Amy Kilbourne , Daniel Almirall

Existing statistical methods for the analysis of micro-randomized trials (MRTs) are designed to estimate causal excursion effects using data from a single MRT. In practice, however, researchers can often find previous MRTs that employ…

Methodology · Statistics 2025-05-13 Easton Huch , Inbal Nahum-Shani , Lindsey Potter , Cho Lam , David W. Wetter , Walter Dempsey

Humans can play a more active role in improving their comfort in the built environment if given the right information at the right place and time. This paper outlines the use of Just-in-Time Adaptive Interventions (JITAI) implemented in the…

Human-Computer Interaction · Computer Science 2025-08-13 Clayton Miller , Yun Xuan Chua , Matias Quintana , Binyu Lei , Filip Biljecki , Mario Frei

Clinicians and researchers alike are increasingly interested in how best to personalize interventions. A dynamic treatment regimen (DTR) is a sequence of pre-specified decision rules which can be used to guide the delivery of a sequence of…

The micro-randomized trial (MRT) is a sequential randomized experimental design to empirically evaluate the effectiveness of mobile health (mHealth) intervention components that may be delivered at hundreds or thousands of decision points.…

Methodology · Statistics 2021-12-14 Jieru Shi , Zhenke Wu , Walter Dempsey

Advances in wearables and digital technology now make it possible to deliver behavioral mobile health interventions to individuals in their everyday life. The micro-randomized trial (MRT) is increasingly used to provide data to inform the…

Methodology · Statistics 2020-07-30 Tianchen Qian , Hyesun Yoo , Predrag Klasnja , Daniel Almirall , Susan A. Murphy

Large language models (LLMs) achieve strong performance in long-horizon decision-making tasks through multi-step interaction and reasoning at test time. While practitioners commonly believe a higher task success rate necessitates the use of…

Artificial Intelligence · Computer Science 2026-05-15 Yuanzhe Li , Jianing Deng , Jingtong Hu , Tianlong Chen , Song Wang , Huanrui Yang

Large language models (LLMs) are increasingly deployed as "agents" for decision-making (DM) in interactive and dynamic environments. Yet, since they were not originally designed for DM, recent studies show that LLMs can struggle even in…

Artificial Intelligence · Computer Science 2025-11-07 Chanwoo Park , Ziyang Chen , Asuman Ozdaglar , Kaiqing Zhang

Micro-randomized trials (MRTs) play a crucial role in optimizing digital interventions. In an MRT, each participant is sequentially randomized among treatment options hundreds of times. While the interventions tested in MRTs target…

Methodology · Statistics 2025-09-04 Tianchen Qian

Due to the recent advancements in wearables and sensing technology, health scientists are increasingly developing mobile health (mHealth) interventions. In mHealth interventions, mobile devices are used to deliver treatment to individuals…

Machine Learning · Computer Science 2020-07-24 Peng Liao , Predrag Klasnja , Susan Murphy

Biomarker-guided designs are increasingly used to evaluate personalized treatments based on patients' biomarker status in Phase II and III clinical trials. With adaptive enrichment, these designs can improve the efficiency of evaluating the…

Methodology · Statistics 2024-06-11 Kaiyuan Hua , Hwanhee Hong , Xiaofei Wang

The recent surge of building software systems powered by Large Language Models (LLMs) has led to the development of various testing frameworks, primarily focused on treating prompt templates as the unit of testing. Despite the significant…

Software Engineering · Computer Science 2025-01-24 Juyeon Yoon , Robert Feldt , Shin Yoo

Cluster or group randomized trials (CRTs) are increasingly used for both behavioral and system-level interventions, where entire clusters are randomly assigned to a study condition or intervention. Apart from the assigned cluster-level…

Methodology · Statistics 2024-11-19 Shubhadeep Chakraborty , Bo Wang , Ram Tiwari , Samiran Ghosh

To empower the iterative assessments involved during a person's rehabilitation, automated assessment of a person's abilities during daily activities requires temporally precise segmentation of fine-grained actions in therapy videos.…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Halil Ismail Helvaci , Justin Huber , Jihye Bae , Sen-ching Samson Cheung

Randomized experiments ensure robust causal inference that are critical to effective learning analytics research and practice. However, traditional randomized experiments, like A/B tests, are limiting in large scale digital learning…

Applications · Statistics 2019-02-04 Timothy NeCamp , Josh Gardner , Christopher Brooks

Technological advancements in the field of mobile devices and wearable sensors have helped overcome obstacles in the delivery of care, making it possible to deliver behavioral treatments anytime and anywhere. Increasingly the delivery of…

Applications · Statistics 2017-11-13 Walter Dempsey , Peng Liao , Santosh Kumar , Susan A. Murphy

Micro-randomized trials (MRTs), which sequentially randomize participants at multiple decision times, have gained prominence in digital intervention development. These sequential randomizations are often subject to certain constraints. In…

Applications · Statistics 2025-01-07 Xiang Meng , Walter Dempsey , Peng Liao , Nick Reid , Pedja Klasnja , Susan Murphy