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Brain pathologies can vary greatly in size and shape, ranging from few pixels (i.e. MS lesions) to large, space-occupying tumors. Recently proposed Autoencoder-based methods for unsupervised anomaly segmentation in brain MRI have shown…

Image and Video Processing · Electrical Eng. & Systems 2020-06-24 Christoph Baur , Benedikt Wiestler , Shadi Albarqouni , Nassir Navab

Alzheimer Disease poses a significant challenge, necessitating early detection for effective intervention. MRI is a key neuroimaging tool due to its ease of use and cost effectiveness. This study analyzes machine learning methods for MRI…

Neurons and Cognition · Quantitative Biology 2024-08-12 Alwani Liyana Ahmad , Jose Sanchez-Bornot , Roberto C. Sotero , Damien Coyle , Zamzuri Idris , Ibrahima Faye

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, structural brain changes, and genetic predispositions. This study leverages machine-learning and statistical techniques to investigate…

Applications · Statistics 2025-10-29 Riddhik Basu , Arkaprava Roy

Alzheimer's disease (AD), defined as an abnormal buildup of amyloid plaques and tau tangles in the brain can be diagnosed with high accuracy based on protein biomarkers via PET or CSF analysis. However, due to the invasive nature of…

Machine Learning · Computer Science 2026-01-27 Megan A. Witherow , Michael L. Evans , Ahmed Temtam , Hamid R. Okhravi , Khan M. Iftekharuddin

Semi-supervised and unsupervised Generative Adversarial Networks (GAN)-based methods have been gaining popularity in anomaly detection task recently. However, GAN training is somewhat challenging and unstable. Inspired from previous work in…

Computer Vision and Pattern Recognition · Computer Science 2019-02-20 Ha Son Vu , Daisuke Ueta , Kiyoshi Hashimoto , Kazuki Maeno , Sugiri Pranata , Sheng Mei Shen

Accurate Computer-Assisted Diagnosis, relying on large-scale annotated pathological images, can alleviate the risk of overlooking the diagnosis. Unfortunately, in medical imaging, most available datasets are small/fragmented. To tackle…

Computer Vision and Pattern Recognition · Computer Science 2019-08-14 Changhee Han , Yoshiro Kitamura , Akira Kudo , Akimichi Ichinose , Leonardo Rundo , Yujiro Furukawa , Kazuki Umemoto , Yuanzhong Li , Hideki Nakayama

Alzheimer's Disease (AD) is an irreversible neurodegenerative disease characterized by progressive cognitive decline as its main symptom. In the research field of deep learning-assisted diagnosis of AD, traditional convolutional neural…

Image and Video Processing · Electrical Eng. & Systems 2025-07-15 Yang Ming , Jiang Shi Zhong , Zhou Su Juan

Medical anomaly detection is a crucial yet challenging task aimed at recognizing abnormal images to assist in diagnosis. Due to the high-cost annotations of abnormal images, most methods utilize only known normal images during training and…

Computer Vision and Pattern Recognition · Computer Science 2023-03-21 Yu Cai , Hao Chen , Xin Yang , Yu Zhou , Kwang-Ting Cheng

Anomaly detection is a fundamental problem in computer vision area with many real-world applications. Given a wide range of images belonging to the normal class, emerging from some distribution, the objective of this task is to construct…

Computer Vision and Pattern Recognition · Computer Science 2020-07-15 Chengwei Chen , Pan Chen , Haichuan Song , Yiqing Tao , Yuan Xie , Shouhong Ding , Lizhuang Ma

Automated and accurate segmentations of left atrium (LA) and atrial scars from late gadolinium-enhanced cardiac magnetic resonance (LGE CMR) images are in high demand for quantifying atrial scars. The previous quantification of atrial scars…

Image and Video Processing · Electrical Eng. & Systems 2021-05-04 Jun Chen , Guang Yang , Habib Khan , Heye Zhang , Yanping Zhang , Shu Zhao , Raad Mohiaddin , Tom Wong , David Firmin , Jennifer Keegan

Segmentation of regions of interest (ROIs) for identifying abnormalities is a leading problem in medical imaging. Using machine learning for this problem generally requires manually annotated ground-truth segmentations, demanding extensive…

Image and Video Processing · Electrical Eng. & Systems 2024-08-19 Jay J. Yoo , Khashayar Namdar , Matthias W. Wagner , Liana Nobre , Uri Tabori , Cynthia Hawkins , Birgit B. Ertl-Wagner , Farzad Khalvati

The goal of anomaly detection is to identify anomalous samples from normal ones. In this paper, a small number of anomalies are assumed to be available at the training stage, but they are assumed to be collected only from several anomaly…

Machine Learning · Computer Science 2022-05-03 Bowen Tian , Qinliang Su , Jian Yin

Image generation has been heavily investigated in computer vision, where one core research challenge is to generate images from arbitrarily complex distributions with little supervision. Generative Adversarial Networks (GANs) as an implicit…

Computer Vision and Pattern Recognition · Computer Science 2021-08-19 Hui Ying , He Wang , Tianjia Shao , Yin Yang , Kun Zhou

Reliable automated analysis of Optical Coherence Tomography (OCT) imaging is crucial for diagnosing retinal disorders but faces a critical barrier: the need for expensive, labor-intensive expert annotations. Supervised deep learning models…

Computer Vision and Pattern Recognition · Computer Science 2026-04-27 Tania Haghighi , Sina Gholami , Hamed Tabkhi , Minhaj Nur Alam

Medical Image Synthesis (MIS) plays an important role in the intelligent medical field, which greatly saves the economic and time costs of medical diagnosis. However, due to the complexity of medical images and similar characteristics of…

Image and Video Processing · Electrical Eng. & Systems 2025-03-07 Zhihan Ju , Wanting Zhou , Longteng Kong , Yu Chen , Yi Li , Zhenan Sun , Caifeng Shan

One of the biggest issues facing the use of machine learning in medical imaging is the lack of availability of large, labelled datasets. The annotation of medical images is not only expensive and time consuming but also highly dependent on…

Structural MRI and PET imaging play an important role in the diagnosis of Alzheimer's disease (AD), showing the morphological changes and glucose metabolism changes in the brain respectively. The manifestations in the brain image of some…

Image and Video Processing · Electrical Eng. & Systems 2023-08-11 Yanteng Zhang , Qizhi Teng , Xiaohai He , Tong Niu , Lipei Zhang , Yan Liu , Chao Ren

Image synthesis via Generative Adversarial Networks (GANs) of three-dimensional (3D) medical images has great potential that can be extended to many medical applications, such as, image enhancement and disease progression modeling. However,…

Image and Video Processing · Electrical Eng. & Systems 2021-07-22 Sungmin Hong , Razvan Marinescu , Adrian V. Dalca , Anna K. Bonkhoff , Martin Bretzner , Natalia S. Rost , Polina Golland

Alzheimer's Disease (AD) is a neurodegenerative disease affecting millions of individuals across the globe. As the prevalence of this disease continues to rise, early diagnosis is crucial to improve clinical outcomes. Neural networks,…

Image and Video Processing · Electrical Eng. & Systems 2024-09-06 Akshay Sunkara , Rajiv Morthala , Anav Jain , Srinjoy Ghose , Santosh Morthala

Unsupervised anomaly detection (UAD) aims to detect anomalies without labeled data, a necessity in many machine learning applications where anomalous samples are rare or not available. Most state-of-the-art methods fall into two categories:…

Machine Learning · Computer Science 2025-07-30 Nicolas Pinon , Carole Lartizien