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Computational models of neurodegeneration aim to emulate the evolving pattern of pathology in the brain during neurodegenerative disease, such as Alzheimer's disease. Previous studies have made specific choices on the mechanisms of…

Quantitative Methods · Quantitative Biology 2023-08-11 Tiantian He , Elinor Thompson , Anna Schroder , Neil P. Oxtoby , Ahmed Abdulaal , Frederik Barkhof , Daniel C. Alexander

Large bundles of myelinated axons, called white matter, anatomically connect disparate brain regions together and compose the structural core of the human connectome. We recently proposed a method of measuring the local integrity along the…

Applications · Statistics 2018-09-18 Yo Joong Choe , Sivaraman Balakrishnan , Aarti Singh , Jean M. Vettel , Timothy Verstynen

The human brain displays a complex network topology, whose structural organization is widely studied using diffusion tensor imaging. The original geometry from which emerges the network topology is known, as well as the localization of the…

Population analyses of functional connectivity have provided a rich understanding of how brain function differs across time, individual, and cognitive task. An important but challenging task in such population analyses is the identification…

Social and Information Networks · Computer Science 2020-08-19 James D. Wilson , Melanie Baybay , Rishi Sankar , Paul Stillman , Abbie M. Popa

Most brain disorders including Alzheimer's disease (AD) are related to alterations in the normal brain network organization and function. Exploring these network alterations using non-invasive and easy to use technique is a topic of great…

Neurons and Cognition · Quantitative Biology 2017-06-14 Aya Kabbara , Mahmoud Hassan , Mohamad Khalil , Wassim El Falou , Hassan Eid

Diffusion MRI imaging and tractography algorithms have enabled the mapping of the macro-scale connectome of the entire brain. At the functional level, probably the simplest way to study the dynamics of macro-scale brain activity is to…

Neurons and Cognition · Quantitative Biology 2022-07-19 Qihang Yao , Manoj Chandrasekaran , Constantine Dovrolis

Cardiovascular waveforms contain information for clinical diagnosis. By "learning" and organizing the subtle change of waveform morphology from large amounts of raw waveform data, unsupervised manifold learning helps delineate a…

Quantitative Methods · Quantitative Biology 2019-12-03 Shen-Chih Wang , Hau-Tieng Wu , Po-Hsun Huang , Cheng-Hsi Chang , Chien-Kun Ting , Yu-Ting Lin

The increasing quantity and quality of the publicly available human cerebral diffusion MRI data make possible the study of the brain as it was unimaginable before. The Consensus Connectome Dynamics (CCD) is a remarkable phenomenon that was…

Neurons and Cognition · Quantitative Biology 2016-10-17 Balázs Szalkai , Vince Grolmusz

We present a mathematical and philosophical framework in which brain function is modeled using sheaf theory over neural state spaces. Local neural or cognitive functions are represented as sections of a sheaf, while global coherence…

Neurons and Cognition · Quantitative Biology 2026-01-23 Takao Inoué

We use the annealed formulation of complex networks to study the dynamical behavior of disease spreading on both static and adaptive networked systems. This unifying approach relies on the annealed adjacency matrix, representing one network…

Physics and Society · Physics 2010-11-09 Beniamino Guerra , Jesus Gomez-Gardenes

The characterisation of the brain as a "connectome", in which the connections are represented by correlational values across timeseries and as summary measures derived from graph theory analyses, has been very popular in the last years.…

Machine Learning · Computer Science 2020-03-13 Tiago Azevedo , Luca Passamonti , Pietro Liò , Nicola Toschi

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by complex physiological processes. Previous research has predominantly focused on static cerebral interactions, often neglecting the brain's dynamic nature and…

Machine Learning · Computer Science 2024-09-11 Peng Wang , Xin Wen , Ruochen Cao , Chengxin Gao , Yanrong Hao , Rui Cao

Human learning is a complex phenomenon that requires adaptive processes across a range of temporal and spacial scales. While our understanding of those processes at single scales has increased exponentially over the last few years, a…

Neurons and Cognition · Quantitative Biology 2016-09-08 Marcelo G. Mattar , Danielle S. Bassett

Brain disorders are an umbrella term for a group of neurological and psychiatric conditions that have a major effect on thinking, feeling, and acting. These conditions encompass a wide range of conditions. The illnesses in question pose…

Neurons and Cognition · Quantitative Biology 2025-11-11 Aniruddha Saha , Soujanya Hazra , Sanjay Ghosh

Today, the human brain can be studied as a whole. Electroencephalography, magnetoencephalography, or functional magnetic resonance imaging techniques provide functional connectivity patterns between different brain areas, and during…

Data Analysis, Statistics and Probability · Physics 2011-01-21 Mario Chavez , Miguel Valencia , Vito Latora , Jacques Martinerie

We propose a novel computational framework for analyzing electroencephalography (EEG) time series using methods from stringology, the study of efficient algorithms for string processing, to systematically identify and characterize recurrent…

Neurons and Cognition · Quantitative Biology 2026-03-05 Anat Dahan , Samah Ghazawi

Sensory perception (e.g. vision) relies on a hierarchy of cortical areas, in which neural activity propagates in both directions, to convey information not only about sensory inputs but also about cognitive states, expectations and…

Neurons and Cognition · Quantitative Biology 2023-04-13 Grégory Faye , Guilhem Fouilhé , Rufin VanRullen

Objective. Modelling is an important way to study the working mechanism of brain. While the characterization and understanding of brain are still inadequate. This study tried to build a model of brain from the perspective of thermodynamics…

Neurons and Cognition · Quantitative Biology 2021-03-30 Chenxi Zhou , Bin Yang , Wenliang Fan , Wei Li

Alterations in functional brain connectivity characterize neurodegenerative disorders such as Alzheimer's disease (AD) and frontotemporal dementia (FTD). As a non-invasive and cost-effective technique, electroencephalography (EEG) is…

Applications · Statistics 2025-11-19 Paolo Victor Redondo , Raphaël Huser , Hernando Ombao

The continuous integration of experimental data into coherent models of the brain is an increasing challenge of modern neuroscience. Such models provide a bridge between structure and activity, and identify the mechanisms giving rise to…

Neurons and Cognition · Quantitative Biology 2017-03-03 Jannis Schuecker , Maximilian Schmidt , Sacha J. van Albada , Markus Diesmann , Moritz Helias