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The hippocampus is one of the most studied neuroanatomical structures due to its involvement in attention, learning, and memory as well as its atrophy in ageing, neurological, and psychiatric diseases. Hippocampal shape changes, however,…

Computer Vision and Pattern Recognition · Computer Science 2023-06-13 Kersten Diers , Hannah Baumeister , Frank Jessen , Emrah Düzel , David Berron , Martin Reuter

Understanding the structure of the brain, and how it changes with time and disease, is a core goal of structural neuroimaging. Contemporary approaches to structural brain analysis are dominated by voxel-wise, mass-univariate methods such as…

Algebraic Topology · Mathematics 2026-04-28 Donato Quiccione , Mariam Pirashvili , Nathan Broomhead , Sean J. Fallon

Mapping of human brain structural connectomes via diffusion MRI offers a unique opportunity to understand brain structural connectivity and relate it to various human traits, such as cognition. However, head displacement during image…

Neurons and Cognition · Quantitative Biology 2024-09-13 Yizi Zhang , Meimei Liu , Zhengwu Zhang , David Dunson

The connectome is a wiring diagram mapping all the neural connections in the brain. At the cellular level, it provides a map of the neurons and synapses within a part or all of the brain of an organism. In recent years, significant advances…

Neurons and Cognition · Quantitative Biology 2022-06-01 Adrián Hernández , José M. Amigó

Brain connectivity analysis is now at the foreground of neuroscience research. A connectivity network is characterized by a graph, where nodes represent neural elements such as neurons and brain regions, and links represent statistical…

Methodology · Statistics 2015-11-04 Yin Xia , Lexin Li

Predicting the evolution of the brain network, also called connectome, by foreseeing changes in the connectivity weights linking pairs of anatomical regions makes it possible to spot connectivity-related neurological disorders in earlier…

Machine Learning · Computer Science 2021-09-17 Şeymanur Aktı , Doğay Kamar , Özgür Anıl Özlü , Ihsan Soydemir , Muhammet Akcan , Abdullah Kul , Islem Rekik

We present a statistical framework that jointly models brain shape and functional connectivity, which are two complex aspects of the brain that have been classically studied independently. We adopt a Riemannian modeling approach to account…

Methodology · Statistics 2024-04-26 Eardi Lila , John A. D. Aston

Subtle alterations in brain network topology often evade detection by traditional statistical methods. To address this limitation, we introduce a Bayesian inference framework for topological comparison of brain networks that…

Methodology · Statistics 2025-11-06 Xukun Zhu , Michael W Lutz , Tananun Songdechakraiwut

Connectomics has emerged as a powerful tool in neuroimaging and has spurred recent advancements in statistical and machine learning methods for connectivity data. Despite connectomes inhabiting a matrix manifold, most analytical frameworks…

Quantitative Methods · Quantitative Biology 2023-03-28 Niharika S. D'Souza , Archana Venkataraman

Modeling the behavior of coupled networks is challenging due to their intricate dynamics. For example in neuroscience, it is of critical importance to understand the relationship between the functional neural processes and anatomical…

Machine Learning · Computer Science 2021-04-20 Hongyuan You , Sikun Lin , Ambuj K. Singh

Neural oscillations are considered to be brain-specific signatures of information processing and communication in the brain. They also reflect pathological brain activity in neurological disorders, thus offering a basis for diagnoses and…

Neurons and Cognition · Quantitative Biology 2023-10-23 Tena Dubcek , Debora Ledergerber , Jana Thomann , Giovanna Aiello , Marc Serra-Garcia , Lukas Imbach , Rafael Polania

Anatomical connectivity between different regions in the brain can be mapped to a network representation, the connectome, where the intensities of the links, the weights, influence its structural resilience and the functional processes it…

Neurons and Cognition · Quantitative Biology 2025-04-09 Laia Barjuan , Muhua Zheng , M. Ángeles Serrano

Tremendous recent literature show that associations between different brain regions, i.e., brain connectivity, provide early symptoms of neurological disorders. Despite significant efforts made for graph neural network (GNN) techniques,…

Computer Vision and Pattern Recognition · Computer Science 2024-09-27 Xin Ma , Guorong Wu , Seong Jae Hwang , Won Hwa Kim

Pathophysiolpgical modelling of brain systems from microscale to macroscale remains difficult in group comparisons partly because of the infeasibility of modelling the interactions of thousands of neurons at the scales involved. Here, to…

Neurons and Cognition · Quantitative Biology 2026-01-30 Kang You , Gary Green , Jian Zhang

A major challenge in neuroscience is posed by the need for relating the emerging dynamical features of brain activity with the underlying modular structure of neural connections, hierarchically organized throughout several scales. The…

Neurons and Cognition · Quantitative Biology 2016-06-03 Pablo Villegas , Jorge Hidalgo , Paolo Moretti , Miguel A. Muñoz

Various Graph Neural Networks (GNNs) have been successful in analyzing data in non-Euclidean spaces, however, they have limitations such as oversmoothing, i.e., information becomes excessively averaged as the number of hidden layers…

Machine Learning · Computer Science 2024-01-23 Jaeyoon Sim , Sooyeon Jeon , InJun Choi , Guorong Wu , Won Hwa Kim

Objective: Modelling the associations from high-throughput experimental molecular data has provided unprecedented insights into biological pathways and signalling mechanisms. Graphical models and networks have especially proven to be useful…

Machine Learning · Statistics 2013-04-24 Marco Scutari , Radhakrishnan Nagarajan

The uncertainty of clinical examinations frequently leads to irregular observation intervals in longitudinal imaging data, posing challenges for modeling disease progression.Most existing imaging-based disease prediction models operate in…

Computer Vision and Pattern Recognition · Computer Science 2025-11-26 Xin Hong , Ying Shi , Yinhao Li , Yen-Wei Chen

Brain connectomics is still largely dominated by pairwise-based models, such as graphs, which cannot represent circulatory or higher-order functional interactions. In this paper, we propose a multimodal framework based on Topological Signal…

Neurons and Cognition · Quantitative Biology 2026-04-01 Breno C. Bispo , Stefania Sardellitti , Juliano B. Lima , Fernando A. N. Santos

Technological advancements in noninvasive imaging facilitate the construction of whole brain interconnected networks, known as brain connectivity. Existing approaches to analyze brain connectivity frequently disaggregate the entire network…

Methodology · Statistics 2023-09-26 Xinyuan Tian , Fan Li , Li Shen , Denise Esserman , Yize Zhao