Related papers: Hepatitis C Virus Epidemic Control Using a Nonline…
This paper presents a scenario-based model predictive control (MPC) scheme designed to control an evolving pandemic via non-pharmaceutical intervention (NPIs). The proposed approach combines predictions of possible pandemic evolution to…
A model based on a thermodynamic approach is proposed for predicting the dynamics of communicable epidemics in a city, when the epidemic is governed by controlling efforts of multiple scales so that an entropy is associated with the system.…
Control-based continuation (CBC) is a general and systematic method to explore the dynamic response of a physical system and perform bifurcation analysis directly during experimental tests. Although CBC has been successfully demonstrated on…
In this paper, we explore the solvability and the optimal control problem for a compartmental model based on reaction-diffusion partial differential equations describing a transmissible disease. The nonlinear model takes into account the…
Background: Liver diseases present a significant global health challenge and often require costly, invasive diagnostics. Electrocardiography (ECG), a widely available and non-invasive tool, can enable the detection of liver disease by…
Medication adherence is essential to ensure treatment effectiveness, but too often in routine care non-adherence compromises the desired outcome. We explore longitudinal causal modelling using observational data to estimate the time-varying…
This paper proposes an approach to mitigate epidemic spread in a population of strategic agents by encouraging safer behaviors through carefully designed rewards. These rewards, which adapt to the evolving state of the epidemic, are…
Hepatitis C virus helicase is a molecular motor that splits nucleic acid duplex structures during viral replication, therefore representing a promising target for antiviral treatment. Hence, a detailed understanding of the mechanism by…
In this paper, a mathematical analysis of the global dynamics of a viral infection model in vivo is carried out. We study the dynamics of a hepatitis C virus (HCV) model, under therapy, that considers both extracellular and intracellular…
We define and examine a model of epidemic propagation for a virus such as Hepatitis C (with HIV co-infection) on a network of networks, namely the network of French urban areas. One network level is that of the individual interactions…
In this paper, we consider an adaptive optimal control problem for an SIR/V epidemic model with human behavioral effects.We develop a model where effective management of infectious diseases are monitored by the means of non pharmaceutical…
A central challenge in Human Immunodeficiency Virus (HIV) public health policy lies in determining whether to universally expand treatment access, despite the risk of sub-optimal adherence and consequent drug resistance, or to adopt a more…
The rates of escape and reversion in response to selection pressure arising from the host immune system, notably the cytotoxic T-lymphocyte (CTL) response, are key factors determining the evolution of HIV. Existing methods for estimating…
We propose and study a compartmental model for epidemiology with human behavioral effects. Specifically, our model incorporates governmental prevention measures aimed at lowering the disease infection rate, but we split the population into…
Optimal control theory in epidemiology has been used to establish the most effective intervention strategies for managing and mitigating the spread of infectious diseases while considering constraints and costs. Using Pontryagin's Maximum…
Hepatitis B virus is a global health threat, and its elimination by 2030 has been prioritised by the World Health Organisation. Here we present an age-structured model for the immune response to an HBV infection, which takes into account…
Infectious zoonotic disease emergence, through spillover events, is of global concern and has the potential to cause significant harm to society, as recently demonstrated by COVID-19. More than 70% of the 400 infectious diseases that…
The host immune response can often efficiently suppress a virus infection, which may lead to selection for immune-resistant viral variants within the host. For example, during HIV infection, an array of CTL immune response populations…
In this paper we present a delay induced model for hepatitis C virus incorporating the healthy and infected hepatocytes as well as infectious and noninfectious virions. The model is mathematically analyzed and characterized, both for the…
The control of opportunistic infections among HIV infected individuals should be one of the major public health concerns in reducing mortality rate of individuals living with HIV/AIDS. In this study a deterministic co-infection mathematical…