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We investigate exploration patterns of a microswimmer, modeled as an active Brownian particle, searching for a target region located in a well of an energy landscape and separated from the initial position of the particle by high barriers.…

Soft Condensed Matter · Physics 2021-09-02 Luigi Zanovello , Pietro Faccioli , Thomas Franosch , Michele Caraglio

Active particles, which are self-propelled nonequilibrium systems, are modelled by overdamped Langevin equations with colored noise, emulating the self-propulsion. In this chapter, we present a review of the theoretical results for the…

Statistical Mechanics · Physics 2025-03-12 Urna Basu , Sanjib Sabhapandit , Ion Santra

Finding the best strategy to minimize the time needed to find a given target is a crucial task both in nature and in reaching decisive technological advances. By considering learning agents able to switch their dynamics between standard and…

In this review, we present the encounter-based approach to target search problems, in which the diffusive dynamics is described by the joint probability of the position of the particle and the number of its encounters with a given target…

Statistical Mechanics · Physics 2025-07-16 Denis S. Grebenkov

We study dynamical properties of confined, self-propelled Brownian particles in an inhomogeneous activity profile. Using Brownian dynamics simulations, we calculate the probability to reach a fixed target and the mean first passage time to…

Soft Condensed Matter · Physics 2019-08-30 Hidde Vuijk , Abhinav Sharma , Debasish Mondal , Jens-Uwe Sommer , Holger Merlitz

Developing behavioral policies designed to efficiently solve target-search problems is a crucial issue both in nature and in the nanotechnology of the 21st century. Here, we characterize the target-search strategies of simple microswimmers…

Soft Condensed Matter · Physics 2023-07-25 Harpreet Kaur , Thomas Franosch , Michele Caraglio

We study the target search of interacting Brownian particles in a finite domain, focusing on the effect of inter-particle interactions on the search time. We derive the integral equation for the mean first-passage time and acquire its…

Statistical Mechanics · Physics 2023-07-12 Sunghan Ro , Juyeon Yi , Yong Woon Kim

In environments with scarce resources, adopting the right search strategy can make the difference between succeeding and failing, even between life and death. At different scales, this applies to molecular encounters in the cell cytoplasm,…

Biological Physics · Physics 2018-09-27 Giorgio Volpe , Giovanni Volpe

In many situations, simply finding a target during a search is not enough. It is equally important to be able to return to that target repeatedly or to enable a larger community to locate and utilize it. While first passage time is commonly…

Soft Condensed Matter · Physics 2025-07-16 Vladimir Yu. Rudyak , Shahar Shinehorn , Yael Roichman

We elaborate and validate a generalization of the renowned transition-path-sampling algorithm for a paradigmatic model of active particles, namely the Run-and-Tumble particles. Notwithstanding the non-equilibrium character of these…

Soft Condensed Matter · Physics 2024-11-20 Thomas Kiechl , Thomas Franosch , Michele Caraglio

The free energy landscapes of several fundamental processes are characterized by high barriers separating long-lived metastable states. In order to explore these type of landscapes enhanced sampling methods are used. While many such methods…

Chemical Physics · Physics 2019-04-12 Jayashrita Debnath , Michele Invernizzi , Michele Parrinello

We report an approach to obtain effective pair potentials which describe the structure of two-dimensional systems of active Brownian particles. The pair potential is found by an inverse method, which matches the radial distribution function…

Activity significantly enhances the escape rate of a Brownian particle over a potential barrier. Whereas constant activity has been extensively studied in the past, little is known about the effect of time-dependent activity on the escape…

Soft Condensed Matter · Physics 2019-07-10 A. Scacchi , J. M. Brader , A. Sharma

In this chapter, we consider the problem of a non-Markovian random walker (displaying memory effects) searching for a target. We review an approach that links the first passage statistics to the properties of trajectories followed by the…

Statistical Mechanics · Physics 2024-01-30 Olivier Bénichou , Thomas Guérin , Nicolas Levernier , Raphaël Voituriez

In this paper, we consider the dynamics of a 2D target-searching agent performing Brownian motion under the influence of fluid shear flow and chemical attraction. The analysis is motivated by numerous situations in biology where these…

Probability · Mathematics 2022-05-31 Yishu Gong , Siming He , Alexander Kiselev

We derive an analytical expression for the propagator and the transition path time distribution of a two-dimensional active Brownian particle crossing a parabolic barrier with absorbing boundary conditions at both sides. By taking those of…

Statistical Mechanics · Physics 2026-01-23 Michele Caraglio

Trajectory optimization of sensing robots to actively gather information of targets has received much attention in the past. It is well-known that under the assumption of linear Gaussian target dynamics and sensor models the stochastic…

Robotics · Computer Science 2021-09-21 Jennifer Wakulicz , He Kong , Salah Sukkarieh

We theoretically address minimal search strategies of active, self-propelled particles towards hidden targets in three-dimensional space. The particles can sense if a target is close, e.g., by detecting signaling molecules released by a…

Soft Condensed Matter · Physics 2021-03-22 Justus A. Kromer , Andrea Auconi , Benjamin M. Friedrich

Unlike equilibrium systems, active matter is not governed by the conventional laws of thermodynamics. Through a series of analytic calculations and Langevin dynamics simulations, we explore how systems cross over from equilibrium to active…

Soft Condensed Matter · Physics 2018-03-28 Ayhan Duzgun , Jonathan V. Selinger

Brownian escape is key to a wealth of physico-chemical processes, including polymer folding, and information storage. The frequency of thermally activated energy barrier crossings is assumed to generally decrease exponentially with…

Soft Condensed Matter · Physics 2020-06-19 Marie Chupeau , Jannes Gladrow , Alexei Chepelianskii , Ulrich F. Keyser , Emmanuel Trizac
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