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Single-cell RNA-sequencing captures a temporal slice, or a snapshot, of a cell differentiation process. A major bioinformatical challenge is the inference of differentiation trajectories from a single snapshot, and methods that account for…

Quantitative Methods · Quantitative Biology 2025-02-11 Magnus Tronstad , Johan Karlsson , Joakim S. Dahlin

We present a neural framework for learning conditional optimal transport (OT) maps between probability distributions. Our approach introduces a conditioning mechanism capable of processing both categorical and continuous conditioning…

Machine Learning · Computer Science 2026-04-02 Carlos Rodriguez-Pardo , Leonardo Chiani , Emanuele Borgonovo , Massimo Tavoni

Variational Auto-Encoders enforce their learned intermediate latent-space data distribution to be a simple distribution, such as an isotropic Gaussian. However, this causes the posterior collapse problem and loses manifold structure which…

Machine Learning · Computer Science 2018-09-18 Huidong Liu , Yang Guo , Na Lei , Zhixin Shu , Shing-Tung Yau , Dimitris Samaras , Xianfeng Gu

We tackle the challenge of disentangled representation learning in generative adversarial networks (GANs) from the perspective of regularized optimal transport (OT). Specifically, a smoothed OT loss gives rise to an implicit transportation…

Machine Learning · Computer Science 2019-12-05 Pierre Bréchet , Tao Wu , Thomas Möllenhoff , Daniel Cremers

Neural network-based optimal transport (OT) is a recent and fruitful direction in the generative modeling community. It finds its applications in various fields such as domain translation, image super-resolution, computational biology and…

Machine Learning · Computer Science 2026-02-25 Roman Tarasov , Petr Mokrov , Milena Gazdieva , Evgeny Burnaev , Alexander Korotin

Distributional data have become increasingly prominent in modern signal processing, highlighting the necessity of computing optimal transport (OT) maps across multiple probability distributions. Nevertheless, recent studies on neural OT…

Machine Learning · Computer Science 2025-04-25 Mingchen Jiang , Peng Xu , Xichen Ye , Xiaohui Chen , Yun Yang , Yifan Chen

Quantifying differences between flow fields is a key challenge in fluid mechanics, particularly when evaluating the effectiveness of flow control. Traditional vector metrics, such as the Euclidean distance, provide straightforward pointwise…

Fluid Dynamics · Physics 2025-11-12 Jonathan Quang Tran , Chi-An Yeh , Kunihiko Taira

Learning from point sets is an essential component in many computer vision and machine learning applications. Native, unordered, and permutation invariant set structure space is challenging to model, particularly for point set…

Computer Vision and Pattern Recognition · Computer Science 2024-03-18 Mohammad Shifat E Rabbi , Naqib Sad Pathan , Shiying Li , Yan Zhuang , Abu Hasnat Mohammad Rubaiyat , Gustavo K Rohde

Generative Adversarial Networks (GANs) are one of the most practical methods for learning data distributions. A popular GAN formulation is based on the use of Wasserstein distance as a metric between probability distributions.…

Machine Learning · Computer Science 2018-05-23 Maziar Sanjabi , Jimmy Ba , Meisam Razaviyayn , Jason D. Lee

We propose an optimal transport (OT) framework for generalized zero-shot learning (GZSL), seeking to distinguish samples for both seen and unseen classes, with the assist of auxiliary attributes. The discrepancy between features and…

Machine Learning · Computer Science 2020-12-29 Wenlin Wang , Hongteng Xu , Guoyin Wang , Wenqi Wang , Lawrence Carin

We study the use of amortized optimization to predict optimal transport (OT) maps from the input measures, which we call Meta OT. This helps repeatedly solve similar OT problems between different measures by leveraging the knowledge and…

Machine Learning · Computer Science 2023-06-06 Brandon Amos , Samuel Cohen , Giulia Luise , Ievgen Redko

The current best practice for computing optimal transport (OT) is via entropy regularization and Sinkhorn iterations. This algorithm runs in quadratic time as it requires the full pairwise cost matrix, which is prohibitively expensive for…

Machine Learning · Computer Science 2022-04-06 Johannes Gasteiger , Marten Lienen , Stephan Günnemann

Learning to align multiple datasets is an important problem with many applications, and it is especially useful when we need to integrate multiple experiments or correct for confounding. Optimal transport (OT) is a principled approach to…

Machine Learning · Computer Science 2021-08-03 Ruishan Liu , Akshay Balsubramani , James Zou

Optimal Transport, a theory for optimal allocation of resources, is widely used in various fields such as astrophysics, machine learning, and imaging science. However, many applications impose elementwise constraints on the transport plan…

Optimization and Control · Mathematics 2022-06-28 Zixuan Cang , Qing Nie , Yanxiang Zhao

Though generative adversarial networks (GANs) areprominent models to generate realistic and crisp images,they often encounter the mode collapse problems and arehard to train, which comes from approximating the intrinsicdiscontinuous…

Computer Vision and Pattern Recognition · Computer Science 2020-01-28 Dongsheng An , Yang Guo , Min Zhang , Xin Qi , Na Lei , Shing-Tung Yau , Xianfeng Gu

We introduce Resonant Anomaly Detection with Optimal Transport (RAD-OT), a method for generating signal templates in resonant anomaly detection searches. RAD-OT leverages the fact that the conditional probability density of the target…

High Energy Physics - Phenomenology · Physics 2024-07-30 Matthew Leigh , Debajyoti Sengupta , Benjamin Nachman , Tobias Golling

Alignment plays a fundamental role in many machine learning problems, such as multi-network analysis, multimodal learning, and point cloud registration. Recent works increasingly leverage optimal transport (OT) for distributional alignment,…

Machine Learning · Computer Science 2026-05-26 Qi Yu , Ruizhong Qiu , Zhichen Zeng , My T. Thai , Huan Liu , Hanghang Tong

Optimal transport (OT) is a widely used technique in machine learning, graphics, and vision that aligns two distributions or datasets using their relative geometry. In symmetry-rich settings, however, OT alignments based solely on pairwise…

Machine Learning · Computer Science 2025-09-26 Annabel Ma , Kaiying Hou , David Alvarez-Melis , Melanie Weber

Optimal transport (OT) has recently been shown as a promising criterion for unsupervised restoration when no explicit prior model is available. Despite its theoretical appeal, OT still significantly falls short of supervised methods on…

Computer Vision and Pattern Recognition · Computer Science 2025-09-17 Fei Wen , Wei Wang , Zeyu Yan , Wenbin Jiang

The design of artificial neural networks (ANNs) is inspired by the structure of the human brain, and in turn, ANNs offer a potential means to interpret and understand brain signals. Existing methods primarily align brain signals with…

Neurons and Cognition · Quantitative Biology 2025-10-08 Yang Xiao , Wang Lu , Jie Ji , Ruimeng Ye , Gen Li , Xiaolong Ma , Bo Hui