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Non-covalent interactions (NCIs) play a crucial role in biology, chemistry, material science, and everything in between. To improve pure quantum-chemical simulations of NCIs, we propose a methodology for constructing approximate correlation…

We present a simple and non-empirical method to determine optimal scaling coefficients, within the (spin-component)-scaled MP2 approach, for calculating intermolecular potential energies of noncovalently-interacting systems. The method is…

Chemical Physics · Physics 2017-09-13 I. Grabowski , E. Fabiano , F. Della Sala

We analyse the effect of intrinsic fluctuations on the properties of bistable stochastic systems with time scale separation operating under1 quasi-steady state conditions. We first formulate a stochastic generalisation of the quasi-steady…

Biological Physics · Physics 2016-03-02 Roberto de la Cruz , Pilar Guerrero , Fabian Spill , Tomás Alarcón

In this study, a machine learning-based technique is developed to reduce the computational cost required to explore large design spaces of substitutional alloys. The first advancement is based on a neural network approach to predict the…

Computational Physics · Physics 2020-04-03 Alhassan S. Yasin , Terence D. Musho

Computationally intractable tasks are often encountered in physics and optimization. Such tasks often comprise a cost function to be optimized over a so-called feasible set, which is specified by a set of constraints. This may yield, in…

Quantum Physics · Physics 2023-04-25 Borja Requena , Gorka Muñoz-Gil , Maciej Lewenstein , Vedran Dunjko , Jordi Tura

The calculation of the MP2 correlation energy for extended systems can be viewed as a multi-dimensional integral in the thermodynamic limit, and the standard method for evaluating the MP2 energy can be viewed as a trapezoidal quadrature…

Computational Physics · Physics 2023-04-10 Xin Xing , Xiaoxu Li , Lin Lin

We extend the recently proposed heat-bath configuration interaction (HCI) method [Holmes, Tubman, Umrigar, J. Chem. Theory Comput. 12, 3674 (2016)], by introducing a semistochastic algorithm for performing multireference Epstein-Nesbet…

Chemical Physics · Physics 2017-03-20 Sandeep Sharma , Adam Holmes , Guillaume Jeanmairet , Ali Alavi , C. J. Umrigar

Finding the maximum cut of a graph (MAXCUT) is a classic optimization problem that has motivated parallel algorithm development. While approximate algorithms to MAXCUT offer attractive theoretical guarantees and demonstrate compelling…

Neural and Evolutionary Computing · Computer Science 2022-10-07 Bradley H. Theilman , Yipu Wang , Ojas D. Parekh , William Severa , J. Darby Smith , James B. Aimone

How condensed-matter simulations depend on the number of molecules being simulated ($N$) is sometimes itself a valuable piece of information. Liquid crystals provide a case in point. Light scattering and $2d$-IR experiments on…

Soft Condensed Matter · Physics 2024-12-20 Eleftherios Mainas , Richard M. Stratt

We present an accurate method for calculating hyperfine coupling constants (HFCCs) based on the complete active space second-order perturbation theory (CASPT2) with full internal contraction. The HFCCs are computed as a first-order property…

Chemical Physics · Physics 2017-03-20 Toru Shiozaki , Takeshi Yanai

The Quark--Meson--Coupling (QMC) model self-consistently relates the dynamics of the internal quark structure of a hadron to the relativistic mean fields arising in nuclear matter. It offers a natural explanation to some open questions in…

Quantum phase estimation (QPE) is a promising quantum algorithm for obtaining molecular ground-state energies with chemical accuracy. However, its computational cost, dominated by the Hamiltonian 1-norm $\lambda$ and the cost of the block…

In this work, we propose and analyze optimization strategies for the VQE algorithm that combine various methods, including molecular point group symmetries (symmetry adaptation), compact excitation circuits (qubit-excitation-based),…

Quantum Physics · Physics 2025-04-30 Konstantin M. Makushin , Aleksey K. Fedorov

Large-scale ML accelerators rely on large numbers of PEs, imposing strict bounds on the area and energy budget of each PE. Prior work demonstrates that limited dual-issue capabilities can be efficiently integrated into a lightweight…

Hardware Architecture · Computer Science 2026-01-27 Luca Colagrande , Luca Benini

Neutrino mass constraints are a primary focus of current and future large-scale structure (LSS) surveys. Non-linear LSS models rely heavily on cosmological simulations -- the impact of massive neutrinos should therefore be included in these…

Cosmology and Nongalactic Astrophysics · Physics 2024-06-11 James M. Sullivan , J. D. Emberson , Salman Habib , Nicholas Frontiere

Applications in robotics or other size-, weight- and power-constrained autonomous systems at the edge often require real-time and low-energy solutions to large optimization problems. Event-based and memory-integrated neuromorphic…

Neural and Evolutionary Computing · Computer Science 2024-06-21 Ashish Rao Mangalore , Gabriel Andres Fonseca Guerra , Sumedh R. Risbud , Philipp Stratmann , Andreas Wild

Analytic energy gradients are presented for a variational two-electron reduced-density-matrix-driven complete active space self-consistent field (v2RDM-CASSCF) procedure that employs the density-fitting (DF) approximation to the…

Chemical Physics · Physics 2018-11-29 J. Wayne Mullinax , Evgeny Epifanovsky , Gergely Gidofalvi , A. Eugene DePrince

We perform a series of calculations using simulated QPUs, accelerated by the NVIDIA CUDA-Q platform, focusing on a molecular analog of an amine-functionalized metal-organic framework (MOF), a promising class of materials for CO$_2$ capture.…

Chemical Physics · Physics 2025-12-16 Jonathan R. Owens , Marwa H. Farag , Pooja Rao , Annarita Giani

Reduced density matrix functional theory (RDMFT) calculations are usually implemented in a decoupled manner, where the orbital and occupation optimizations are repeated alternately. Typically, orbital updates are performed using the unitary…

Chemical Physics · Physics 2024-09-04 Yi-Fan Yao , Neil Qiang Su

We investigate the sign problem for full configuration interaction quantum Monte Carlo (FCIQMC), a stochastic algorithm for finding the ground state solution of the Schr\"odinger equation with substantially reduced computational cost…

Computational Physics · Physics 2014-11-05 James J. Shepherd , Gustavo E. Scuseria , James S. Spencer