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Omic data are characterized by the presence of strong dependence structures that result either from data acquisition or from some underlying biological processes. In metabolomics, for instance, data resulting from Liquid Chromatography-Mass…

In high-dimensional survival analysis, effective variable selection is crucial for both model interpretation and predictive performance. This paper investigates Cox regression with lasso and adaptive lasso penalties in genomic datasets…

Methodology · Statistics 2025-07-02 Pilar González-Barquero , Rosa E. Lillo , Álvaro Méndez-Civieta

Analysis of high-dimensional data is currently a popular field of research, thanks to many applications e.g. in genetics (DNA data in genomewide association studies), spectrometry or web analysis. At the same time, the type of problems that…

Methodology · Statistics 2018-05-25 Jozef Jakubik

Penalized regression models such as the Lasso have proved useful for variable selection in many fields - especially for situations with high-dimensional data where the numbers of predictors far exceeds the number of observations. These…

Methodology · Statistics 2014-03-19 Kasper Brink-Jensen , Claus Thorn Ekstrøm

Variable selection is a difficult problem that is particularly challenging in the analysis of high-dimensional genomic data. Here, we introduce the CAR score, a novel and highly effective criterion for variable ranking in linear regression…

Methodology · Statistics 2011-07-20 Verena Zuber , Korbinian Strimmer

We propose an extensive simulation study to compare some variable selection procedures in a high-dimensional framework. Assuming that the relationship between the actives variables and the response variable is linear, the high-dimensional…

Applications · Statistics 2025-03-21 Perrine Lacroix , Mélina Gallopin , Marie-Laure Martin

The construction of coherent prediction models holds great importance in medical research as such models enable health researchers to gain deeper insights into disease epidemiology and clinicians to identify patients at higher risk of…

Applications · Statistics 2024-01-17 Guanbo Wang , Sylvie Perreault , Robert W. Platt , Rui Wang , Marc Dorais , Mireille E. Schnitzer

Variable selection is a procedure to attain the truly important predictors from inputs. Complex nonlinear dependencies and strong coupling pose great challenges for variable selection in high-dimensional data. In addition, real-world…

Methodology · Statistics 2023-07-04 Keyao Wang , Huiwen Wang , Jichang Zhao , Lihong Wang

Genome-scale gene networks contain regulatory genes called hubs that have many interaction partners. These genes usually play an essential role in gene regulation and cellular processes. Despite recent advancements in high-throughput…

Quantitative Methods · Quantitative Biology 2017-10-06 Nurgazy Sulaimanov , Sunil Kumar , Frédéric Burdet , Mark Ibberson , Marco Pagni , Heinz Koeppl

Sparse regression such as the Lasso has achieved great success in handling high-dimensional data. However, one of the biggest practical problems is that high-dimensional data often contain large amounts of missing values. Convex Conditioned…

Machine Learning · Statistics 2019-06-20 Masaaki Takada , Hironori Fujisawa , Takeichiro Nishikawa

In machine learning one of the strategic tasks is the selection of only significant variables as predictors for the response(s). In this paper an approach is proposed which consists in the application of permutation tests on the candidate…

Many data sets consist of variables with an inherent group structure. The problem of group selection has been well studied, but in this paper, we seek to do the opposite: our goal is to select at least one variable from each group in the…

Methodology · Statistics 2015-05-29 Frederick Campbell , Genevera I. Allen

Causal effect estimation is a critical task in statistical learning that aims to find the causal effect on subjects by identifying causal links between a number of predictor (or, explanatory) variables and the outcome of a treatment. In a…

Methodology · Statistics 2024-11-26 Tathagata Basu , Matthias C. M. Troffaes

We propose a new approach to safe variable preselection in high-dimensional penalized regression, such as the lasso. Preselection - to start with a manageable set of covariates - has often been implemented without clear appreciation of its…

With the emergence of high-throughput technologies, it is possible to measure large amounts of data relatively at low cost. Such situations arise in many fields from sciences to humanities, and variable selection may be of great help to…

Computation · Statistics 2021-08-17 Jung Nicolas , Frédéric Bertrand , Myriam Maumy-Bertrand

In life sciences, the experts generally use empirical knowledge to recode variables, choose interactions and perform selection by classical approach. The aim of this work is to perform automatic learning algorithm for variables selection…

Machine Learning · Statistics 2015-11-05 Bienvenue Kouwayè , Noël Fonton , Fabrice Rossi

Recently, considerable interest has focused on variable selection methods in regression situations where the number of predictors, $p$, is large relative to the number of observations, $n$. Two commonly applied variable selection approaches…

Applications · Statistics 2011-04-19 Peter Radchenko , Gareth M. James

We study the problem of high-dimensional regression when there may be interacting variables. Approaches using sparsity-inducing penalty functions such as the Lasso can be useful for producing interpretable models. However, when the number…

Methodology · Statistics 2016-12-30 Rajen D. Shah

Variable selection, also known as feature selection in machine learning, plays an important role in modeling high dimensional data and is key to data-driven scientific discoveries. We consider here the problem of detecting influential…

Methodology · Statistics 2014-09-24 Bo Jiang , Jun S. Liu

Advances in data collecting technologies in genomics have significantly increased the need for tools designed to study the genetic basis of many diseases. Effective statistical methods should excel in both prediction accuracy and biomarker…

Methodology · Statistics 2025-11-13 Anthony-Alexander Christidis , Stefan Van Aelst , Ruben Zamar