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Distributed point charge models (DCM) and their minimal variants (MDCM) have been integrated with tools widely used for condensed-phase simulations, including a virial-based barostat and a slow-growth algorithm for thermodynamic…

Chemical Physics · Physics 2020-11-03 Mike Devereux , Marco Pezzella , Shampa Raghunathan , Markus Meuwly

In recent years, molecular dynamics (MD) simulations have emerged as a pivotal tool for understanding the structure, dynamics, and phase behavior in charged soft matter systems. To explore phenomena across greater length and time scales in…

Computational Physics · Physics 2024-07-18 Benjamin Bobin Ye , Shensheng Chen , Zhen-Gang Wang

Accurate modelling of electrostatic interactions and charge transfer is fundamental to computational chemistry, yet most machine learning interatomic potentials (MLIPs) rely on local atomic descriptors that cannot capture long-range…

Vibrational properties of molecular crystals are constantly used as structural fingerprints, in order to identify both the chemical nature and the structural arrangement of molecules. The simulation of these properties is typically very…

Computational Physics · Physics 2019-10-09 Nathaniel Raimbault , Andrea Grisafi , Michele Ceriotti , Mariana Rossi

We present teraflop-scale calculations of biomolecular electrostatics enabled by the combination of algorithmic and hardware acceleration. The algorithmic acceleration is achieved with the fast multipole method (FMM) in conjunction with a…

Computational Engineering, Finance, and Science · Computer Science 2011-09-21 Rio Yokota , Jaydeep P. Bardhan , Matthew G. Knepley , L. A. Barba , Tsuyoshi Hamada

Typical biomolecular systems such as cellular membranes, DNA, and protein complexes are highly charged. Thus, efficient and accurate treatment of electrostatic interactions is of great importance in computational modelling of such systems.…

Soft Condensed Matter · Physics 2007-05-23 Michael Patra , Marja T. Hyvonen , Emma Falck , Mohsen Sabouri-Ghomi , Ilpo Vattulainen , Mikko Karttunen

The quality of biomolecular simulations critically depends on the accuracy of the force field used to calculate the potential energy of the molecular configurations. Currently, most simulations employ non-polarisable force fields, which…

Biological Physics · Physics 2020-02-11 V. S. Sandeep Inakollu , Daan P. Geerke , Christopher N. Rowley , Haibo Yu

We propose a very simple but realistic enough model which allows to include a large number of molecules in molecular dynamics MD simulations of these bilayers, but nevertheless taking into account molecular charge distributions, flexible…

Soft Condensed Matter · Physics 2009-11-13 Z. Gamba

Electrostatics is of paramount importance to chemistry, physics, biology, and medicine. The Poisson-Boltzmann (PB) theory is a primary model for electrostatic analysis. However, it is highly challenging to compute accurate PB electrostatic…

Chemical Physics · Physics 2023-12-20 Jiahui Chen , Yongjia Xu , Xin Yang , Zixuan Cang , Weihua Geng , Guo-Wei Wei

Electrostatic interactions play crucial roles in biophysical processes such as protein folding and molecular recognition. Poisson-Boltzmann equation (PBE)-based models have emerged as widely used in modeling these important processes.…

Computational Physics · Physics 2017-04-11 Ruxi Qi , Wesley M. Botello-Smith , Ray Luo

Molecular dynamics simulations are an invaluable tool in numerous scientific fields. However, the ubiquitous classical force fields cannot describe reactive systems, and quantum molecular dynamics are too computationally demanding to treat…

Chemical Physics · Physics 2022-08-09 Xiangyun Lei , Andrew J. Medford

Simulating the dynamics of ions near polarizable nanoparticles (NPs) using coarse-grained models is extremely challenging due to the need to solve the Poisson equation at every simulation timestep. Recently, a molecular dynamics (MD) method…

Computational Physics · Physics 2019-11-01 JCS Kadupitiya , Geoffrey C. Fox , Vikram Jadhao

We propose a new multi-scale molecular dynamics simulation method which can achieve high accuracy and high sampling efficiency simultaneously without aforehand knowledge of the coarse grained (CG) potential and test it for a biomolecular…

Biological Physics · Physics 2009-08-05 Wenfei Li , Shoji Takada

We propose an efficient algorithm for the evaluation of the potential and its gradient of gravitational/electrostatic $N$-body systems, which we call particle mesh multipole method (PMMM or PM$^3$). PMMM can be understood both as an…

Instrumentation and Methods for Astrophysics · Physics 2014-10-20 Keigo Nitadori

Because most chemical or biological experiments are performed under conditions of controlled pressure and temperature, it is important to simulate the isobaric-isothermal ensemble at the atomic level to reveal the microscopic mechanism. By…

Statistical Mechanics · Physics 2025-04-14 Weihao Liang , Sihan Wang , Cong Wang , Weizhou Wang , Xinchen She , Chongbin Wang , Jiushu Shao , Jian Liu

Accounting for geometry-induced changes in the electronic distribution in molecular simulation is important for capturing effects such as charge flow, charge anisotropy and polarization. Multipolar force fields have demonstrated their…

Chemical Physics · Physics 2022-07-01 Eric D. Boittier , Mike Devereux , Markus Meuwly

A class of variational schemes for the hydrodynamic-electrodynamic model of lossless free-electron gas in a quasineutral background is developed for high-quality simulations of surface plasmon polaritons. The Lagrangian density of lossless…

Computational Physics · Physics 2019-02-27 Qiang Chen , Lifei Geng , Xiang Chen , Xiaojun Hao , Chuanchuan Wang , Xiaoyang Wang

Electrostatic forces play many important roles in molecular biology, but are hard to model due to the complicated interactions between biomolecules and the surrounding solvent, a fluid composed of water and dissolved ions. Continuum model…

Numerical Analysis · Mathematics 2015-12-29 Jaydeep P. Bardhan , Matthew G. Knepley

Point multipole expansions are widely used to gain physical insight into complex distributions of charges and to reduce the cost of computing interactions between such distributions. However, practical applications that typically retain…

Classical Physics · Physics 2015-06-03 Charles Baker , Ramu Anandakrishnan , Alexey Onufriev

This study introduces a novel approach utilizing Gaussian process model predictive control (MPC) to stabilize the output voltage of a polymer electrolyte fuel cell (PEFC) system by simultaneously regulating hydrogen and airflow rates. Two…

Systems and Control · Electrical Eng. & Systems 2024-03-26 Xiufei Li , Miao Zhang , Yuanxin Qi , Miao Yang
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