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How DNA-binding proteins locate specific genomic targets remains a central challenge in molecular biology. Traditional protein-centric approaches, which rely on wet-lab experiments and visualization techniques, often lack genome-wide…

Quantitative Methods · Quantitative Biology 2025-09-16 Li Yang , Dongbo Wang

RNA-binding proteins (RBPs) play crucial roles in many biological processes, e.g. gene regulation. Computational identification of RBP binding sites on RNAs are urgently needed. In particular, RBPs bind to RNAs by recognizing sequence…

Genomics · Quantitative Biology 2018-06-07 Xiaoyong Pan , Junchi Yan

N6-methyladenosine (m6A) is a prevalent RNA post-transcriptional modification that plays crucial roles in RNA stability, structural dynamics, and interactions with proteins. The YT521-B (YTH) family of proteins, which are notable m6A…

Biomolecules · Quantitative Biology 2024-09-10 Valerio Piomponi , Miroslav Krepl , Jiri Sponer , Giovanni Bussi

This study presents a novel method for improving rice disease classification using 8 different convolutional neural network (CNN) algorithms, which will further the field of precision agriculture. Tkinter-based application that offers…

Computer Vision and Pattern Recognition · Computer Science 2024-10-04 Biplov Paneru , Bishwash Paneru , Krishna Bikram Shah

Crop diseases present a significant barrier to agricultural productivity and global food security, especially in large-scale farming where early identification is often delayed or inaccurate. This research introduces a Convolutional Neural…

Computer Vision and Pattern Recognition · Computer Science 2025-07-15 Sourish Suri , Yifei Shao

Accurate identification of protein-nucleotide binding sites is fundamental to deciphering molecular mechanisms and accelerating drug discovery. However, current computational methods often struggle with suboptimal performance due to…

Machine Learning · Computer Science 2026-03-17 Yiming Gao , Liuyi Xu , Pengshan Cui , Yining Qian , An-Yang Lu , Xianpeng Wang

N6-methyladenosine (m6A) is the most abundant mRNA modification within mammalian cells, holding pivotal significance in the regulation of mRNA stability, translation, and splicing. Furthermore, it plays a critical role in the regulation of…

Molecular Networks · Quantitative Biology 2024-01-17 Ting-He Zhang , Sumin Jo , Michelle Zhang , Kai Wang , Shou-Jiang Gao , Yufei Huang

Computational drug discovery provides an efficient tool helping large scale lead molecules screening. One of the major tasks of lead discovery is identifying molecules with promising binding affinities towards a target, a protein in…

Biological Physics · Physics 2019-09-18 Liangzhen Zheng , Jingrong Fan , Yuguang Mu

An accurate and timely detection of diseases and pests in rice plants can help farmers in applying timely treatment on the plants and thereby can reduce the economic losses substantially. Recent developments in deep learning based…

Computer Vision and Pattern Recognition · Computer Science 2020-04-15 Chowdhury Rafeed Rahman , Preetom Saha Arko , Mohammed Eunus Ali , Mohammad Ashik Iqbal Khan , Sajid Hasan Apon , Farzana Nowrin , Abu Wasif

With the rapid growth in the semiconductor industry, it is becoming critical to detect and classify increasingly smaller patterned defects. Recently machine learning, including deep learning, has come to aid in this endeavor in a big way.…

Mesoscale and Nanoscale Physics · Physics 2022-11-24 Ravikiran Attota

Near-field channel estimation is a fundamental challenge in the sixth-generation (6G) wireless communication, where extremely large antenna arrays (ELAA) enable near-field communication (NFC) but introduce significant signal processing…

Signal Processing · Electrical Eng. & Systems 2025-05-21 Vu Tung Lam , Do Hai Son , Tran Thi Thuy Quynh , Le Trung Thanh

Machine learning has become a major field of research in order to handle more and more complex image detection problems. Among the existing state-of-the-art CNN models, in this paper a region-based, fully convolutional network, for fast and…

Computer Vision and Pattern Recognition · Computer Science 2019-06-06 Mohammad Ibrahim Sarker , Hyongsuk Kim

Cell-free DNA (cfDNA) analysis is a powerful, minimally invasive tool for monitoring disease progression, treatment response, and early detection. A major challenge, however, is accurately determining the tissue of origin, especially in…

Genomics · Quantitative Biology 2025-06-03 Keng-Jung Lee , Dharanya Sampath , Konstantinos Mavrommatis

In this paper we use convolutional neural networks (CNNs) for weed detection in agricultural land. We specifically investigate the application of two CNN layer types, Conv2d and dilated Conv2d, for weed detection in crop fields. The…

Computer Vision and Pattern Recognition · Computer Science 2025-02-21 Santosh Kumar Tripathi , Shivendra Pratap Singh , Devansh Sharma , Harshavardhan U Patekar

Rice leaf diseases significantly reduce productivity and cause economic losses, highlighting the need for early detection to enable effective management and improve yields. This study proposes Artificial Neural Network (ANN)-based…

Computer Vision and Pattern Recognition · Computer Science 2025-07-04 Farida Siddiqi Prity , Mirza Raquib , Saydul Akbar Murad , Md. Jubayar Alam Rafi , Md. Khairul Bashar Bhuiyan , Anupam Kumar Bairagi

Rice is an essential staple food worldwide that is important in promoting international trade, economic growth, and nutrition. Asian countries such as China, India, Pakistan, Thailand, Vietnam, and Indonesia are notable for their…

Computer Vision and Pattern Recognition · Computer Science 2026-01-15 Muhammad Junaid Asif , Hamza Khan , Rabia Tehseen , Rana Fayyaz Ahmad , Mujtaba Asad , Syed Tahir Hussain Rizvi , Shazia Saqib

Although Convolutional neural networks (CNNs) are widely used for plant disease detection, they require a large number of training samples when dealing with wide variety of heterogeneous background. In this work, a CNN based dual phase…

Computer Vision and Pattern Recognition · Computer Science 2021-05-11 Tashin Ahmed , Chowdhury Rafeed Rahman , Md. Faysal Mahmud Abid

Splice sites play a crucial role in gene expression, and accurate prediction of these sites in DNA sequences is essential for diagnosing and treating genetic disorders. We address the challenge of splice site prediction by introducing…

Genomics · Quantitative Biology 2023-11-23 Asmita Poddar , Vladimir Uzun , Elizabeth Tunbridge , Wilfried Haerty , Alejo Nevado-Holgado

Rice is a staple food of global importance in terms of trade, nutrition, and economic growth. Among Asian nations such as China, India, Pakistan, Thailand, Vietnam and Indonesia are leading producers of both long and short grain varieties,…

Computer Vision and Pattern Recognition · Computer Science 2025-08-28 Hamza Khan

Background: Recent assays for individual-specific genome-wide DNA methylation profiles have enabled epigenome-wide association studies to identify specific CpG sites associated with a phenotype. Computational prediction of CpG site-specific…

Genomics · Quantitative Biology 2015-11-12 Weiwei Zhang , Tim D Spector , Panos Deloukas , Jordana T Bell , Barbara E Engelhardt
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