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Topological defects in nematically aligned cell populations play a critical role in modulating collective motion, from microbial colonies to epithelial tissues. Despite the potential of manipulating such topological defects to control…

Soft Condensed Matter · Physics 2023-07-25 Ryo Ienaga , Kazusa Beppu , Yusuke T. Maeda

Directional media, such as nematic liquid crystals and ferromagnets, are characterized by their topologically stabilized defects in directional order. In nematics, boundary conditions and surface-treated inclusions often create complex…

Soft Condensed Matter · Physics 2015-06-03 Simon Čopar , Slobodan Žumer

Collective cell migration governs a range of physiological and pathological processes, from tissue morphogenesis to cancer invasion, in which topological defects arise as an inevitable consequence of frequent cellular rearrangement and…

Soft Condensed Matter · Physics 2026-04-01 Jiusi Zhang , Chung Wing Chan , Bo Li , Rui Zhang

The topological properties of many materials are central to their behavior, with the dynamics of topological defects being particularly important to intrinsically out-of-equilibrium, active materials. In this paper, local manipulation of…

Soft Condensed Matter · Physics 2019-11-01 David P. Rivas , Tyler N. Shendruk , Robert R. Henry , Daniel H. Reich , Robert L. Leheny

Topological defects play a critical role across many fields, mediating phase transitions and macroscopic behaviors as they move through space. Their role as robust information carriers has also generated much attention. However, controlling…

Cultured stem cells have become a standard platform not only for regenerative medicine and developmental biology but also for biophysical studies. Yet, the characterization of cultured stem cells at the level of morphology and macroscopic…

Soft Condensed Matter · Physics 2022-06-23 Kyogo Kawaguchi , Ryoichiro Kageyama , Masaki Sano

We investigate both the hyperbolic action and the determinant ratio action designed to fix the topological charge on the lattice. We show to what extent topology is fixed depending on the parameters of these actions, keeping the physical…

High Energy Physics - Lattice · Physics 2010-04-08 Falk Bruckmann , Florian Gruber , Karl Jansen , Marina Marinkovic , Carsten Urbach , Marc Wagner

In confluent cell monolayers, patterns of cell forces and motion are systematically altered near topological defects in cell shape. In turn, defects have been proposed to alter cell density, extrusion, and invasion, but it remains unclear…

Biological Physics · Physics 2025-08-11 Pradip K. Bera , Molly McCord , Jun Zhang , Jacob Notbohm

Inspired by recent experiments of cells accumulating on anisotropic substrates, we study a two-dimensional, compressible, isotropic, active fluid in the presence of anisotropic friction. We find that regions of anisotropic friction that are…

Soft Condensed Matter · Physics 2026-03-04 Cody D. Schimming , Brian A. Camley

Topological defects play a central role in the formation and organization of various biological systems. Historically, such nonequilibrium defects have been mainly studied in the context of homogeneous active nematics. Phase-separated…

Soft Condensed Matter · Physics 2023-07-13 Timo Krüger , Ivan Maryshev , Erwin Frey

Active emulsions and liquid crystalline shells are intriguing and experimentally realisable types of topological matter. Here we numerically study the morphology and spatiotemporal dynamics of a double emulsion, where one or two passive…

Active nematics contain topological defects which under sufficient activity move, create and annihilate in a chaotic quasi-steady state, called active turbulence. However, understanding active defects under confinement is an open challenge,…

Soft Condensed Matter · Physics 2019-10-02 Simon Čopar , Jure Aplinc , Žiga Kos , Slobodan Žumer , Miha Ravnik

We derive and numerically solve a surface active nematodynamics model. We validate the numerical approach on a sphere and analyse the influence of hydrodynamics on the oscillatory motion of topological defects. For ellipsoidal surfaces the…

Soft Condensed Matter · Physics 2022-09-07 Michael Nestler , Axel Voigt

We establish how active stress globally affects the morphology of disclination lines of a three dimensional active nematic liquid crystal under chaotic flow. Thanks to a defect detection algorithm based on the local nematic orientation, we…

Soft Condensed Matter · Physics 2025-06-30 Pasquale Digregorio , Cecilia Rorai , Ignacio Pagonabarraga , Federico Toschi

Active matter is naturally out of equilibrium which results in the emergence of diverse dynamic steady states, including the omnipresent chaotic state known as the active turbulence. However, much less is known how active systems…

Soft Condensed Matter · Physics 2023-04-07 Nika Kralj , Miha Ravnik , Žiga Kos

The tenfold classification provides a powerful framework for organizing topological phases of matter based on symmetry and spatial dimension. However, it does not offer a systematic method for transitioning between classes or engineering…

Mesoscale and Nanoscale Physics · Physics 2025-08-08 Amit Goft , Eric Akkermans

Monolayers of anisotropic cells exhibit long-ranged orientational order and topological defects. During the development of organisms, orientational order often influences morphogenetic events. However, the linkage between the mechanics of…

Soft Condensed Matter · Physics 2021-01-20 Carles Blanch-Mercader , Pau Guillamat , Aurélien Roux , Karsten Kruse

Recent experiments and numerical studies have drawn attention to the dynamics of active nematics. Two-dimensional active nematics flow spontaneously and exhibit spatiotemporal chaotic flows with proliferation of topological defects in the…

Soft Condensed Matter · Physics 2020-07-08 Farzan Vafa , Mark J. Bowick , M. Cristina Marchetti , Boris I. Shraiman

Collective guidance of out-of-equilibrium systems without using external fields is a challenge of paramount importance in active matter, ranging from bacterial colonies to swarms of self-propelled particles. Designing strategies to guide…

Active systems, from bacterial suspensions to cellular monolayers, are continuously driven out of equilibrium by local injection of energy from their constituent elements and exhibit turbulent-like and chaotic patterns. Here we demonstrate…

Soft Condensed Matter · Physics 2016-02-04 Amin Doostmohammadi , Michael F. Adamer , Sumesh P. Thampi , Julia M. Yeomans