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Due to the lack of fine-grained annotation guidance, current Multiple Instance Learning (MIL) struggles to establish a robust causal relationship between Whole Slide Image (WSI) diagnosis and evidence sub-images, just like fully supervised…

Computer Vision and Pattern Recognition · Computer Science 2025-07-08 Tianhang Nan , Yong Ding , Hao Quan , Deliang Li , Lisha Li , Guanghong Zhao , Xiaoyu Cui

Histopathology image analysis is the golden standard of clinical diagnosis for Cancers. In doctors daily routine and computer-aided diagnosis, the Whole Slide Image (WSI) of histopathology tissue is used for analysis. Because of the…

Computer Vision and Pattern Recognition · Computer Science 2023-11-23 Honglin Li , Yunlong Zhang , Chenglu Zhu , Jiatong Cai , Sunyi Zheng , Lin Yang

Recent advances in deep learning have relied on large, labelled datasets to train high-capacity models. However, collecting large datasets in a time- and cost-efficient manner often results in label noise. We present a method for learning…

Computer Vision and Pattern Recognition · Computer Science 2022-07-07 Ahmet Iscen , Jack Valmadre , Anurag Arnab , Cordelia Schmid

Semi-supervised learning has attracted much attention due to its less dependence on acquiring abundant annotations from experts compared to fully supervised methods, which is especially important for medical image segmentation which…

Computer Vision and Pattern Recognition · Computer Science 2024-10-24 Yichi Zhang , Jin Yang , Yuchen Liu , Yuan Cheng , Yuan Qi

In medical image analysis, multi-organ semi-supervised segmentation faces challenges such as insufficient labels and low contrast in soft tissues. To address these issues, existing studies typically employ semi-supervised segmentation…

Computer Vision and Pattern Recognition · Computer Science 2024-12-31 Feilong Tang , Zhongxing Xu , Ming Hu , Wenxue Li , Peng Xia , Yiheng Zhong , Hanjun Wu , Jionglong Su , Zongyuan Ge

Researchers working on computational analysis of Whole Slide Images (WSIs) in histopathology have primarily resorted to patch-based modelling due to large resolution of each WSI. The large resolution makes WSIs infeasible to be fed directly…

Computer Vision and Pattern Recognition · Computer Science 2021-06-08 Suvidha Tripathi , Satish Kumar Singh , Hwee Kuan Lee

We provide in this paper a comprehensive comparison of various transfer learning strategies and deep learning architectures for computer-aided classification of adult-type diffuse gliomas. We evaluate the generalizability of out-of-domain…

Confidence-based pseudo-label selection usually generates overly confident yet incorrect predictions, due to the early misleadingness of model and overfitting inaccurate pseudo-labels in the learning process, which heavily degrades the…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Peng Zhang , Zhihui Lai , Heng Kong

Annotating large-scale LiDAR point clouds for 3D semantic segmentation is costly and time-consuming, which motivates the use of semi-supervised learning (SemiSL). Standard LiDAR SemiSL methods typically adopt a two-step training paradigm,…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Bin Yang , Alexandru Paul Condurache

Deep learning-based medical image segmentation helps assist diagnosis and accelerate the treatment process while the model training usually requires large-scale dense annotation datasets. Weakly semi-supervised medical image segmentation is…

Computer Vision and Pattern Recognition · Computer Science 2024-11-19 Shiman Li , Jiayue Zhao , Shaolei Liu , Xiaokun Dai , Chenxi Zhang , Zhijian Song

Semi-supervised 3D medical image segmentation aims to achieve accurate segmentation using few labelled data and numerous unlabelled data. The main challenge in the design of semi-supervised learning methods consists in the effective use of…

Computer Vision and Pattern Recognition · Computer Science 2025-02-18 Yanyan Wang , Kechen Song , Yuyuan Liu , Shuai Ma , Yunhui Yan , Gustavo Carneiro

Nuclei instance segmentation on histopathology images is of great clinical value for disease analysis. Generally, fully-supervised algorithms for this task require pixel-wise manual annotations, which is especially time-consuming and…

Computer Vision and Pattern Recognition · Computer Science 2023-06-06 Yang Zhou , Yongjian Wu , Zihua Wang , Bingzheng Wei , Maode Lai , Jianzhong Shou , Yubo Fan , Yan Xu

Data labeling is often the most challenging task when developing computational pathology models. Pathologist participation is necessary to generate accurate labels, and the limitations on pathologist time and demand for large, labeled…

Quantitative Methods · Quantitative Biology 2021-11-12 Lantian Zhang , Mohamed Amgad , Lee A. D. Cooper

Large-scale vision models like SAM have extensive visual knowledge, yet their general nature and computational demands limit their use in specialized tasks like medical image segmentation. In contrast, task-specific models such as U-Net++…

Image and Video Processing · Electrical Eng. & Systems 2025-03-11 Yuchen Mao , Hongwei Li , Yinyi Lai , Giorgos Papanastasiou , Peng Qi , Yunjie Yang , Chengjia Wang

Manually segmenting the hepatic vessels from Computer Tomography (CT) is far more expertise-demanding and laborious than other structures due to the low-contrast and complex morphology of vessels, resulting in the extreme lack of…

Image and Video Processing · Electrical Eng. & Systems 2021-06-04 Zhe Xu , Donghuan Lu , Yixin Wang , Jie Luo , Jayender Jagadeesan , Kai Ma , Yefeng Zheng , Xiu Li

Recent advancements in computational pathology and artificial intelligence have significantly improved whole slide image (WSI) classification. However, the gigapixel resolution of WSIs and the scarcity of manual annotations present…

Computer Vision and Pattern Recognition · Computer Science 2024-08-26 Mingxi Ouyang , Yuqiu Fu , Renao Yan , ShanShan Shi , Xitong Ling , Lianghui Zhu , Yonghong He , Tian Guan

Noisy labels, inevitably existing in pseudo segmentation labels generated from weak object-level annotations, severely hampers model optimization for semantic segmentation. Previous works often rely on massive hand-crafted losses and…

Computer Vision and Pattern Recognition · Computer Science 2024-01-23 Shenwang Jiang , Jianan Li , Ying Wang , Wenxuan Wu , Jizhou Zhang , Bo Huang , Tingfa Xu

Whole Slide Images (WSIs) or histopathology images are used in digital pathology. WSIs pose great challenges to deep learning models for clinical diagnosis, owing to their size and lack of pixel-level annotations. With the recent…

Computer Vision and Pattern Recognition · Computer Science 2024-02-14 Soham Rohit Chitnis , Sidong Liu , Tirtharaj Dash , Tanmay Tulsidas Verlekar , Antonio Di Ieva , Shlomo Berkovsky , Lovekesh Vig , Ashwin Srinivasan

Whole Slide Images (WSIs) in digital pathology are used to diagnose cancer subtypes. The difference in procedures to acquire WSIs at various trial sites gives rise to variability in the histopathology images, thus making consistent…

Image and Video Processing · Electrical Eng. & Systems 2022-04-07 Milad Sikaroudi , Shahryar Rahnamayan , H. R. Tizhoosh

The analysis of the tumor environment on digital histopathology slides is becoming key for the understanding of the immune response against cancer, supporting the development of novel immuno-therapies. We introduce here a novel deep…

Image and Video Processing · Electrical Eng. & Systems 2019-06-27 Ansh Kapil , Tobias Wiestler , Simon Lanzmich , Abraham Silva , Keith Steele , Marlon Rebelatto , Guenter Schmidt , Nicolas Brieu
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