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As advancements in novel biomarker-based algorithms and models accelerate disease risk prediction and stratification in medicine, it is crucial to evaluate these models within the context of their intended clinical application. Prediction…

Methodology · Statistics 2025-09-11 Kehao Zhu , Yingye Zheng , Kwun Chuen Gary Chan

Despite the ongoing strong interest in associations between quality of care and the volume of health care providers, a unified statistical framework for analyzing them is missing, and many studies suffer from poor statistical modelling…

Methodology · Statistics 2025-03-17 Maurilio Gutzeit , Johannes Rauh , Maximilian Kähler , Jona Cederbaum

The propensity score analysis is one of the most widely used methods for studying the causal treatment effect in observational studies. This paper studies treatment effect estimation with the method of matching weights. This method…

Methodology · Statistics 2011-05-17 Liang Li

Hospital profiling involves a comparison of a health care provider's structure, processes of care, or outcomes to a standard, often in the form of a report card. Given the ubiquity of report cards and similar consumer ratings in…

Methodology · Statistics 2009-09-29 Sharon-Lise T. Normand , David M. Shahian

Existing weighting methods for treatment effect estimation are often built upon the idea of propensity scores or covariate balance. They usually impose strong assumptions on treatment assignment or outcome model to obtain unbiased…

Machine Learning · Computer Science 2023-05-09 Dongcheng Zhang , Kunpeng Zhang

Estimating individual and average treatment effects from observational data is an important problem in many domains such as healthcare and e-commerce. In this paper, we advocate balance regularization of multi-head neural network…

Machine Learning · Computer Science 2020-11-24 Mehrdad Farajtabar , Andrew Lee , Yuanjian Feng , Vishal Gupta , Peter Dolan , Harish Chandran , Martin Szummer

Ordinal outcomes are common in clinical settings where they often represent increasing levels of disease progression or different levels of functional impairment. Such outcomes can characterize differences in meaningful patient health…

In observational studies, the recorded treatment assignment is not purely random, but it is influenced by external factors such as patient characteristics, reimbursement policies, and existing guidelines. Therefore, the treatment effect can…

Methodology · Statistics 2024-09-02 Sara Poletto , Enrico Longato , Erica Tavazzi , Martina Vettoretti

Gathering observational data for medical decision-making often involves uncertainties arising from both type I (false positive)and type II (false negative) errors. In this work, we develop a statistical model to study how medical…

Applications · Statistics 2025-10-21 Lucas Böttcher , Maria R. D'Orsogna , Tom Chou

We consider real-time timely tracking of infection status (e.g., covid-19) of individuals in a population. In this work, a health care provider wants to detect infected people as well as people who have recovered from the disease as quickly…

Information Theory · Computer Science 2022-06-15 Melih Bastopcu , Sennur Ulukus

We investigate the estimation of subgroup treatment effects with observational data. Existing propensity score matching and weighting methods are mostly developed for estimating overall treatment effect. Although the true propensity score…

Methodology · Statistics 2017-07-20 Jing Dong , Junni L Zhang , Fan Li

Randomized clinical trials are the gold standard when estimating the average treatment effect. However, they are usually not a random sample from the real-world population because of the inclusion/exclusion rules. Meanwhile, observational…

Methodology · Statistics 2024-12-11 Kuan Jiang , Wenjie Hu , Shu Yang , Xinxing Lai , Xiaohua Zhou

In epidemiological studies, participants' disease status is often collected through self-reported outcomes in place of formal medical tests due to budget constraints. However, self-reported outcomes are often subject to measurement errors,…

Methodology · Statistics 2023-06-21 Yujie Wu , Molin Wang

Medical errors are a major public health concern and a leading cause of death worldwide. Many healthcare centers and hospitals use reporting systems where medical practitioners write a preliminary medical report and the report is later…

Information Retrieval · Computer Science 2020-05-01 Sean MacAvaney , Arman Cohan , Nazli Goharian , Ross Filice

There are many clinical contexts which require accurate detection and segmentation of all focal pathologies (e.g. lesions, tumours) in patient images. In cases where there are a mix of small and large lesions, standard binary cross entropy…

Image and Video Processing · Electrical Eng. & Systems 2022-05-19 Brennan Nichyporuk , Justin Szeto , Douglas L. Arnold , Tal Arbel

It is important to estimate the local average treatment effect (LATE) when compliance with a treatment assignment is incomplete. The previously proposed methods for LATE estimation required all relevant variables to be jointly observed in a…

Machine Learning · Statistics 2022-03-22 Kazuhiko Shinoda , Takahiro Hoshino

Covariate adjustment is a general method for improving precision when estimating treatment effects in randomized trials and is recommended by the FDA in its 2023 guidance when baseline variables are prognostic for the primary outcome. We…

Probability samples are the preferred method for providing inferences that are generalizable to a larger population. However, when a small (or rare) subpopulation is the group of interest, this approach is unlikely to yield a sample size…

Methodology · Statistics 2019-08-13 Michael W. Robbins , Bonnie Ghosh-Dastidar , Rajeev Ramchand

Randomized controlled trials are the gold standard for measuring causal effects. However, they are often not always feasible, and causal treatment effects must be estimated from observational data. Observational studies do not allow robust…

Computing averages over a target probability density by statistical re-weighting of a set of samples with a different distribution is a strategy which is commonly adopted in fields as diverse as atomistic simulation and finance. Here we…

Chemical Physics · Physics 2012-02-21 Michele Ceriotti , Guy A. R. Brain , Oliver Riordan , David E. Manolopoulos
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