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Cycling tissues such as the intestinal epithelium, germ line, and hair follicles, require a constant flux of differentiated cells. These tissues are maintained by a population of stem cells, which generate differentiated progenies and…

Cell Behavior · Quantitative Biology 2013-05-20 Sahand Hormoz

We consider a one-dimensional dyadic branching Brownian motion on $\mathbb{R}$ with positive drift $\beta \in (0,1)$, branching rate $1/2$, reflected at $0$ and killed at a boundary $L > 0$. The killing boundary $L$ is chosen so that the…

Probability · Mathematics 2026-04-06 Florin Boenkost , Julie Tourniaire

Asymmetric damage segregation (ADS) is ubiquitous among unicellular organisms: After a mother cell divides, its two daughter cells receive sometimes slightly, sometimes strongly different fractions of damaged proteins accumulated in the…

Populations and Evolution · Quantitative Biology 2023-02-17 Arkady Pikovsky , Lev S. Tsimring

The standard diffusive spreading, characterized by a Gaussian distribution with mean square displacement that grows linearly with time, can break down, for instance, under the presence of correlations and heterogeneity. In this work, we…

Statistical Mechanics · Physics 2021-10-27 M. A. F. dos Santos , E. H. Colombo , C. Anteneodo

In this work we approach cell migration under a large-scale assumption, so that the system reduces to a particle in motion. Unlike classical particle models, the cell displacement results from its internal activity: the cell velocity is a…

Cell Behavior · Quantitative Biology 2018-08-02 Christèle Etchegaray , Nicolas Meunier

This paper theoretically analyzes a phenomenological stochastic model for bacterial growth. This model comprises cell division and the linear growth of cells, where growth rates and cell cycles are drawn from lognormal distributions. We…

Biological Physics · Physics 2016-06-28 Ken Yamamoto , Jun-ichi Wakita

Density dependent Markov population processes in large populations of size $N$ were shown by Kurtz (1970, 1971) to be well approximated over finite time intervals by the solution of the differential equations that describe their average…

Probability · Mathematics 2014-10-15 A. D. Barbour , Kais Hamza , Haya Kaspi , Fima Klebaner

Cell division times in microbial populations display significant fluctuations, that impact the population growth rate in a non-trivial way. If fluctuations are uncorrelated among different cells, the population growth rate is predicted by…

Populations and Evolution · Quantitative Biology 2021-07-07 Simone Pigolotti

Structured populations are ubiquitous across the biological sciences. Mathematical models of these populations allow us to understand how individual physiological traits drive the overall dynamics in aggregate. For example, linear age- or…

Analysis of PDEs · Mathematics 2022-04-25 Sabina L. Altus , Jeffrey C. Cameron , David M. Bortz

We are interested in modelling Darwinian evolution, resulting from the interplay of phenotypic variation and natural selection through ecological interactions. Our models are rooted in the microscopic, stochastic description of a population…

Probability · Mathematics 2016-08-16 Nicolas Champagnat , Régis Ferrière , Sylvie Méléard

This article studies the quasi-stationary behaviour of multidimensional birth and death processes, modeling the interaction between several species, absorbed when one of the coordinates hits 0. We study models where the absorption rate is…

Probability · Mathematics 2015-08-14 Nicolas Champagnat , Denis Villemonais

Inspired by one--dimensional light--particle systems, the dynamics of a non-Hamiltonian system with long--range forces is investigated. While the molecular dynamics does not reach an equilibrium state, it may be approximated in the…

Statistical Mechanics · Physics 2019-01-23 Romain Bachelard , Nicola Piovella , Shamik Gupta

Phenomena as diverse as breeding bird populations, the size of U.S. firms, money invested in mutual funds, the GDP of individual countries and the scientific output of universities all show unusual but remarkably similar growth…

Physics and Society · Physics 2010-05-03 Yonathan Schwarzkopf , Robert L. Axtell , J. Doyne Farmer

Consider the population model with infinite size associated to subcritical continuous-state branching processes (CSBP). Individuals reproduce independently according to the same subcritical offspring distribution. We study the long-term…

Probability · Mathematics 2020-12-08 Clément Foucart , Martin Möhle

Motivated by modeling the dynamics of a population living in a flowing medium where the environmental factors are random in space, we have studied an asymmetric variant of the one-dimensional contact process, where the quenched random…

Disordered Systems and Neural Networks · Physics 2015-06-16 Róbert Juhász

For taxonomic levels higher than species, the abundance distributions of number of subtaxa per taxon tend to approximate power laws, but often show strong deviationns from such a law. Previously, these deviations were attributed to…

Biological Physics · Physics 2009-11-06 Johan Chu , Chris Adami

Markovian growth-fragmentation processes introduced by Bertoin model a system of growing and splitting cells in which the size of a typical cell evolves as a Markov process $X$ without positive jumps. We find that two growth-fragmentation…

Probability · Mathematics 2020-02-05 Quan Shi

Segregation of populations is a key question in evolution theory. One important aspect is the relation between spatial organization and the population's composition. Here we study a specific example -- sectors in expanding bacterial…

Condensed Matter · Physics 2009-10-31 Ido Golding , Inon Cohen , Eshel Ben-Jacob

Branching processes are widely used to model phenomena from networks to neuronal avalanching. In a large class of continuous-time branching processes, we study the temporal scaling of the moments of the instant population size, the survival…

Statistical Mechanics · Physics 2018-12-18 Rosalba Garcia-Millan , Johannes Pausch , Benjamin Walter , Gunnar Pruessner

We ask the question "when will natural selection on a gene in a spatially structured population cause a detectable trace in the patterns of genetic variation observed in the contemporary population?". We focus on the situation in which…

Probability · Mathematics 2016-11-17 Alison Etheridge , Nic Freeman , Sarah Penington , Daniel Straulino