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Poor performance of quantitative analysis in histopathological Whole Slide Images (WSI) has been a significant obstacle in clinical practice. Annotating large-scale WSIs manually is a demanding and time-consuming task, unlikely to yield the…

Computer Vision and Pattern Recognition · Computer Science 2023-08-08 Sarah Cechnicka , James Ball , Hadrien Reynaud , Callum Arthurs , Candice Roufosse , Bernhard Kainz

Automatic histopathology image segmentation is crucial to disease analysis. Limited available labeled data hinders the generalizability of trained models under the fully supervised setting. Semi-supervised learning (SSL) based on generative…

Computer Vision and Pattern Recognition · Computer Science 2020-12-18 Hongxiao Wang , Hao Zheng , Jianxu Chen , Lin Yang , Yizhe Zhang , Danny Z. Chen

In this paper, we propose a new image instance segmentation method that segments individual glands (instances) in colon histology images. This is a task called instance segmentation that has recently become increasingly important. The…

Computer Vision and Pattern Recognition · Computer Science 2016-07-15 Yan Xu , Yang Li , Mingyuan Liu , Yipei Wang , Maode Lai , Eric I-Chao Chang

Annotation is a major hurdle in the semantic segmentation of microscopy images and volumes due to its prerequisite expertise and effort. This work enables the training of semantic segmentation networks on images with only a single point for…

Computer Vision and Pattern Recognition · Computer Science 2021-03-22 Shijie Li , Neel Dey , Katharina Bermond , Leon von der Emde , Christine A. Curcio , Thomas Ach , Guido Gerig

In this paper, we develop a new weakly-supervised learning algorithm to learn to segment cancerous regions in histopathology images. Our work is under a multiple instance learning framework (MIL) with a new formulation, deep weak…

Computer Vision and Pattern Recognition · Computer Science 2017-08-30 Zhipeng Jia , Xingyi Huang , Eric I-Chao Chang , Yan Xu

Traditional supervised medical image segmentation models require large amounts of labeled data for training; however, obtaining such large-scale labeled datasets in the real world is extremely challenging. Recent semi-supervised…

Computer Vision and Pattern Recognition · Computer Science 2025-05-26 Yunyao Lu , Yihang Wu , Reem Kateb , Ahmad Chaddad

Segmentation of histological images is one of the most crucial tasks for many biomedical analyses including quantification of certain tissue type. However, challenges are posed by high variability and complexity of structural features in…

Computer Vision and Pattern Recognition · Computer Science 2020-07-30 Xiaohang Fu , Tong Liu , Zhaohan Xiong , Bruce H. Smaill , Martin K. Stiles , Jichao Zhao

Accurate segmentation and classification of nuclei in histology images is critical but challenging due to nuclei heterogeneity, staining variations, and tissue complexity. Existing methods often struggle with limited dataset variability,…

Image and Video Processing · Electrical Eng. & Systems 2025-01-22 Wenhua Zhang , Sen Yang , Meiwei Luo , Chuan He , Yuchen Li , Jun Zhang , Xiyue Wang , Fang Wang

Despite the remarkable performance of deep learning methods on various tasks, most cutting-edge models rely heavily on large-scale annotated training examples, which are often unavailable for clinical and health care tasks. The labeling…

Computer Vision and Pattern Recognition · Computer Science 2021-03-02 Jialin Peng , Ye Wang

Classifying the various shapes and attributes of a glioma cell nucleus is crucial for diagnosis and understanding the disease. We investigate automated classification of glioma nuclear shapes and visual attributes using Convolutional Neural…

Computer Vision and Pattern Recognition · Computer Science 2017-01-11 Veda Murthy , Le Hou , Dimitris Samaras , Tahsin M. Kurc , Joel H. Saltz

The automated segmentation of cancer tissue in histopathology images can help clinicians to detect, diagnose, and analyze such disease. Different from other natural images used in many convolutional networks for benchmark, histopathology…

Computer Vision and Pattern Recognition · Computer Science 2021-08-06 Juan P. Vigueras-Guillén , Joan Lasenby , Frank Seeliger

Analysis of histopathology slides is a critical step for many diagnoses, and in particular in oncology where it defines the gold standard. In the case of digital histopathological analysis, highly trained pathologists must review vast…

Computer Vision and Pattern Recognition · Computer Science 2020-02-21 Pierre Courtiol , Eric W. Tramel , Marc Sanselme , Gilles Wainrib

Automatic segmentation of microscopy images is an important task in medical image processing and analysis. Nucleus detection is an important example of this task. Mask-RCNN is a recently proposed state-of-the-art algorithm for object…

Computer Vision and Pattern Recognition · Computer Science 2021-04-01 Jeremiah W. Johnson

Melanoma is the most lethal form of skin cancer, with an increasing incidence rate worldwide. Analyzing histological images of melanoma by localizing and classifying tissues and cell nuclei is considered the gold standard method for…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Nima Torbati , Anastasia Meshcheryakova , Ramona Woitek , Sepideh Hatamikia , Diana Mechtcheriakova , Amirreza Mahbod

When applying automatic analysis of fluorescence or histopathological images of cells, it is necessary to partition, or de-clump, partially overlapping cell nuclei. In this work, I describe a method of partitioning partially overlapping…

Computer Vision and Pattern Recognition · Computer Science 2018-04-13 James Kapaldo

In this paper we propose a novel deep learning-based algorithm for biomedical image segmentation which uses a sequential attention mechanism able to shift the focus of attention across the image in a selective way, allowing subareas which…

Computer Vision and Pattern Recognition · Computer Science 2019-09-30 Shohei Hayashi , Bisser Raytchev , Toru Tamaki , Kazufumi Kaneda

Accurate segmentation of 3-D cell nuclei in microscopy images is essential for the study of nuclear organization, gene expression, and cell morphodynamics. Current image segmentation methods are challenged by the complexity and variability…

Image and Video Processing · Electrical Eng. & Systems 2022-03-18 Sundaresh Ram , Jeffrey J. Rodriguez

One of the most effective ways to treat liver cancer is to perform precise liver resection surgery, the key step of which includes precise digital image segmentation of the liver and its tumor. However, traditional liver parenchymal…

Other Quantitative Biology · Quantitative Biology 2024-06-11 Danyi Huang , Ziang Liu , Yizhou Li

Accurate segmentation of kidneys and kidney tumors is an essential step for radiomic analysis as well as developing advanced surgical planning techniques. In clinical analysis, the segmentation is currently performed by clinicians from the…

Image and Video Processing · Electrical Eng. & Systems 2020-06-05 Wenshuai Zhao , Dihong Jiang , Jorge Peña Queralta , Tomi Westerlund

Due to its superior efficiency in utilizing annotations and addressing gigapixel-sized images, multiple instance learning (MIL) has shown great promise as a framework for whole slide image (WSI) classification in digital pathology…

Quantitative Methods · Quantitative Biology 2023-07-14 Qiehe Sun , Jiawen Li , Jin Xu , Junru Cheng , Tian Guan , Yonghong He