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This paper is concerned with false discovery rate (FDR) control in large-scale multiple testing problems. We first propose a new data-driven testing procedure for controlling the FDR in large-scale t-tests for one-sample mean problem. The…

Statistics Theory · Mathematics 2020-03-02 Changliang Zou , Haojie Ren , Xu Guo , Runze Li

Activity in coupled systems is often oscillatory, for example, the firing pattern of neuronal populations. Whereas these oscillations have been studied predominantly in local circuits, here we show how the topology of large-scale networks,…

Neurons and Cognition · Quantitative Biology 2014-05-15 Marcus Kaiser

We consider the performance of the bootstrap in high-dimensions for the setting of linear regression, where $p<n$ but $p/n$ is not close to zero. We consider ordinary least-squares as well as robust regression methods and adopt a minimalist…

Methodology · Statistics 2016-08-03 Noureddine El Karoui , Elizabeth Purdom

We propose a distributed bootstrap method for simultaneous inference on high-dimensional massive data that are stored and processed with many machines. The method produces an $\ell_\infty$-norm confidence region based on a…

Methodology · Statistics 2022-06-15 Yang Yu , Shih-Kang Chao , Guang Cheng

In stochastic simulation, input uncertainty refers to the output variability arising from the statistical noise in specifying the input models. This uncertainty can be measured by a variance contribution in the output, which, in the…

Methodology · Statistics 2021-05-20 Henry Lam , Huajie Qian

Neuroscience has recently made much progress, expanding the complexity of both neural-activity measurements and brain-computational models. However, we lack robust methods for connecting theory and experiment by evaluating our new big…

Quantitative Methods · Quantitative Biology 2023-07-06 Heiko H. Schütt , Alexander D. Kipnis , Jörn Diedrichsen , Nikolaus Kriegeskorte

Structural equation models and Bayesian networks have been widely used to study causal relationships between continuous variables. Recently, a non-Gaussian method called LiNGAM was proposed to discover such causal models and has been…

Machine Learning · Statistics 2010-06-23 Yusuke Komatsu , Shohei Shimizu , Hidetoshi Shimodaira

Bootstrapping is often applied to get confidence limits for semiparametric inference of a target parameter in the presence of nuisance parameters. Bootstrapping with replacement can be computationally expensive and problematic when…

Multiscale is a hallmark feature of complex nonlinear systems. While the simulation using the classical numerical methods is restricted by the local \textit{Taylor} series constraints, the multiscale techniques are often limited by finding…

Dynamical Systems · Mathematics 2024-05-07 Asif Hamid , Danish Rafiq , Shahkar Ahmad Nahvi , Mohammad Abid Bazaz

For situations that may benefit from information sharing among datasets, e.g., population-based SHM of similar structures, the hierarchical Bayesian approach provides a useful modelling structure. Hierarchical Bayesian models learn…

Machine Learning · Computer Science 2024-01-04 T. A. Dardeno , K. Worden , N. Dervilis , R. S. Mills , L. A. Bull

Deep neural networks are used in many state-of-the-art systems for machine perception. Once a network is trained to do a specific task, e.g., bird classification, it cannot easily be trained to do new tasks, e.g., incrementally learning to…

Artificial Intelligence · Computer Science 2017-11-10 Ronald Kemker , Marc McClure , Angelina Abitino , Tyler Hayes , Christopher Kanan

Background: Data driven stratification of patients into biologically informed subtypes holds promise for precision neuropsychiatry, yet neuroimaging-based clustering methods often fail to generalize across cohorts. While algorithmic…

Machine Learning · Computer Science 2025-06-12 Yuetong Yu , Ruiyang Ge , Ilker Hacihaliloglu , Alexander Rauscher , Roger Tam , Sophia Frangou

The rise in complexity of network data in neuroscience, social networks, and protein-protein interaction networks has been accompanied by several efforts to model and understand these data at different scales. A key multiscale network…

Methodology · Statistics 2025-03-04 Al-Fahad Al-Qadhi , Keith Levin , Vincent Lyzinski

Meta-analysis represents a widely accepted approach for evaluating the accuracy of diagnostic tools in clinical and psychological investigations. This paper investigates the applicability of multinomial tree models recently suggested in the…

Methodology · Statistics 2024-05-29 Annamaria Guolo

The usage of psychological networks that conceptualize psychological behavior as a complex interplay of psychological and other components has gained increasing popularity in various fields of psychology. While prior publications have…

Applications · Statistics 2017-01-23 Sacha Epskamp , Denny Borsboom , Eiko I. Fried

When we use simulation to evaluate the performance of a stochastic system, the simulation often contains input distributions estimated from real-world data; therefore, there is both simulation and input uncertainty in the performance…

Methodology · Statistics 2020-11-10 Wei Xie , Barry L. Nelson , Russell R. Barton

Hierarchical clustering is an effective, interpretable method for analyzing structure in data. It reveals insights at multiple scales without requiring a predefined number of clusters and captures nested patterns and subtle relationships,…

A pervasive challenge in neuroscience is testing whether neuronal connectivity changes over time due to specific causes, such as stimuli, events, or clinical interventions. Recent hardware innovations and falling data storage costs enable…

Neurons and Cognition · Quantitative Biology 2024-01-05 Johan Medrano , Karl J. Friston , Peter Zeidman

High-dimensional data must be highly structured to be learnable. Although the compositional and hierarchical nature of data is often put forward to explain learnability, quantitative measurements establishing these properties are scarce.…

Machine Learning · Statistics 2025-03-04 Antonio Sclocchi , Alessandro Favero , Noam Itzhak Levi , Matthieu Wyart

There has been a surge in the number of large and flat data sets - data sets containing a large number of features and a relatively small number of observations - due to the growing ability to collect and store information in medical…

Machine Learning · Statistics 2017-07-05 Hongyang Zhang , Ruben H. Zamar