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Seizure and synchronization are related to each other in complex manner. Altered synchrony has been implicated in loss of consciousness during partial seizures. However, the mechanism of altered consciousness following termination of…

Neurons and Cognition · Quantitative Biology 2018-01-30 Puneet Dheer , Sandipan Pati , Srinath Jayachandran , Kaushik Kumar Majumdar

Temporal-lobe epilepsy in humans is often associated with widespread, synchronized neuron firing that co-occurs with traveling waves in local field potential. These traveling waves generate stochastic oscillations in a time series of…

Neurons and Cognition · Quantitative Biology 2023-01-18 Francois A. Marshall

Epilepsy is a chronic neurological disorder that affects a significant portion of the human population and imposes serious risks in the daily life of patients. Despite advances in machine learning and IoT, small, nonstigmatizing wearable…

Machine Learning · Computer Science 2023-02-22 Una Pale , Tomas Teijeiro , David Atienza

Most of the temporal lobe epilepsy detection approaches are based on hippocampus deformation and use complicated features, resulting, detection is done with complicated features extraction and pre-processing task. In this paper, a new…

Computer Vision and Pattern Recognition · Computer Science 2016-12-30 Zohreh Kohan , Hamidreza Farhidzadeh , Reza Azmi , Behrouz Gholizadeh

Joint modeling of diffusion and relaxation has seen growing interest due to its potential to provide complementary information about tissue microstructure. For brain white matter, we designed an optimal diffusion-relaxometry MRI protocol…

Currently, approximately 30% of epileptic patients treated with antiepileptic drugs (AEDs) remain resistant to treatment (known as refractory patients). This project seeks to understand the underlying similarities in refractory patients vs.…

Machine Learning · Computer Science 2017-04-28 David Von Dollen

Epilepsy is one of the most common neurological disorders that can be diagnosed through electroencephalogram (EEG), in which the following epileptic events can be observed: pre-ictal, ictal, post-ictal, and interictal. In this paper, we…

Machine Learning · Computer Science 2021-02-12 Jefferson Tales Oliva , João Luís Garcia Rosa

In this study, we developed and tested machine learning models to predict epilepsy surgical outcome using noninvasive clinical and demographic data from patients. Methods: Seven dif-ferent categorization algorithms were used to analyze the…

Objective: Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by unpredictable flares. This study aimed to develop a novel proteomics-based risk prediction model specifically for Asian SLE populations to…

Genomics · Quantitative Biology 2024-11-20 Liying Chen , Ou Deng , Ting Fang , Mei Chen , Xvfeng Zhang , Ruichen Cong , Dingqi Lu , Runrun Zhang , Qun Jin , Xinchang Wang

This paper considers identification and estimation of causal effect parameters from participating in a binary treatment in a difference in differences (DID) setup when the parallel trends assumption holds after conditioning on observed…

Econometrics · Economics 2024-06-25 Carolina Caetano , Brantly Callaway , Stroud Payne , Hugo Sant'Anna Rodrigues

Multivariate equivalence testing is needed in a variety of scenarios for drug development. For example, drug products obtained from natural sources may contain many components for which the individual effects and/or their interactions on…

Methodology · Statistics 2024-06-07 Chao Wang , Yu-Ting Weng , Shaobo Liu , Tengfei Li , Meiyu Shen , Yi Tsong

Background and Objectives: Many biological processes are modulated by rhythms on circadian and multidien timescales. In focal epilepsy, various seizure features, such as spread and duration, can change from one seizure to the next within…

The electroencephalographic (EEG) data intracerebrally recorded from 20 epileptic humans with different brain origins of focal epilepsies or types of seizures, ages and sexes are investigated (nearly 700 million data). Multi channel…

Biological Physics · Physics 2010-02-19 Caglar Tuncay

Damage to the white matter underlying the left posterior temporal lobe leads to deficits in multiple language functions. The posterior temporal white matter may correspond to a bottleneck where both dorsal and ventral language pathways are…

Neurons and Cognition · Quantitative Biology 2016-09-08 Joseph C. Griffis , Rodolphe Nenert , Jane B. Allendorfer , Jerzy P. Szaflarski

Background: People with bipolar disorder (BD) tend to show widespread cognitive impairment compared to healthy controls. Impairments in processing speed (PS), attention, and executive function (EF) may represent 'core' impairments that have…

Neurons and Cognition · Quantitative Biology 2023-11-06 Bethany Little , Carly Flowers , Andrew Blamire , Peter Thelwall , John-Paul Taylor , Peter Gallagher , David Andrew Cousins , Yujiang Wang

This contribution reports an application of MultiFractal Detrended Fluctuation Analysis, MFDFA based novel feature extraction technique for automated detection of epilepsy. In fractal geometry, Multifractal Detrended Fluctuation Analysis…

Computer Vision and Pattern Recognition · Computer Science 2017-04-06 S Pratiher , S Chatterjee , R Bose

Objectives: To examine the distribution, temporal associations, and age/sex-specific patterns of multiple long-term conditions (MLTCs) in adults with intellectual disability (ID). Study Design: Observational study using longitudinal…

Tractography algorithms are used extensively to delineate white matter structures, by operating on the voxel-wise information generated through the application of diffusion tensor imaging (DTI) or other models to diffusion weighted (DW)…

Quantitative Methods · Quantitative Biology 2024-03-05 Richard G. Carson , Alexander Leemans

Epilepsy is a network disease. The epileptic network usually involves spatially distributed brain regions. In this context, noninvasive M/EEG source connectivity is an emerging technique to identify functional brain networks at cortical…

Neurons and Cognition · Quantitative Biology 2016-08-18 Mahmoud Hassan , Isabelle Merlet , Ahmad Mheich , Aya Kabbara , Arnaud Biraben , Anca Nica , Fabrice Wendling

Amyotrophic lateral sclerosis is a fatal disease that not only affects movement, speech, and breath but also cognition. Recent studies have focused on the use of language analysis techniques to detect ALS and infer scales for monitoring…

Computation and Language · Computer Science 2023-09-14 Carla Agurto , Guillermo Cecchi , Bo Wen , Ernest Fraenkel , James Berry , Indu Navar , Raquel Norel