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The two-stage methods for instance segmentation, e.g. Mask R-CNN, have achieved excellent performance recently. However, the segmented masks are still very coarse due to the downsampling operations in both the feature pyramid and the…

Computer Vision and Pattern Recognition · Computer Science 2021-04-20 Gang Zhang , Xin Lu , Jingru Tan , Jianmin Li , Zhaoxiang Zhang , Quanquan Li , Xiaolin Hu

Precise segmentation of the liver is critical for computer-aided diagnosis such as pre-evaluation of the liver for living donor-based transplantation surgery. This task is challenging due to the weak boundaries of organs, countless…

Image and Video Processing · Electrical Eng. & Systems 2021-09-06 Supriti Mulay , Deepika G , Jeevakala S , Keerthi Ram , Mohanasankar Sivaprakasam

Liver cancer is one of the most common malignant diseases in the world. Segmentation and labeling of liver tumors and blood vessels in CT images can provide convenience for doctors in liver tumor diagnosis and surgical intervention. In the…

Image and Video Processing · Electrical Eng. & Systems 2022-03-01 Xiangyu Meng , Xudong Zhang , Gan Wang , Ying Zhang , Xin Shi , Huanhuan Dai , Zixuan Wang , Xun Wang

Accurately and quickly binuclear cell (BC) detection plays a significant role in predicting the risk of leukemia and other malignant tumors. However, manual microscopy counting is time-consuming and lacks objectivity. Moreover, with the…

Computer Vision and Pattern Recognition · Computer Science 2022-08-29 Baomin Wang , Geng Hu , Dan Chen , Lihua Hu , Cheng Li , Yu An , Guiping Hu , Guang Jia

While convolutional neural networks have gained impressive success recently in solving structured prediction problems such as semantic segmentation, it remains a challenge to differentiate individual object instances in the scene. Instance…

Machine Learning · Computer Science 2017-07-14 Mengye Ren , Richard S. Zemel

Accurate and efficient cell detection is crucial in many biomedical image analysis tasks. We evaluate the performance of several Deep Learning (DL) methods for cell detection in Papanicolaou-stained cytological Whole Slide Images (WSIs),…

Computer Vision and Pattern Recognition · Computer Science 2026-01-15 Marco Acerbis , Nataša Sladoje , Joakim Lindblad

Due to its superior efficiency in utilizing annotations and addressing gigapixel-sized images, multiple instance learning (MIL) has shown great promise as a framework for whole slide image (WSI) classification in digital pathology…

Quantitative Methods · Quantitative Biology 2023-07-14 Qiehe Sun , Jiawen Li , Jin Xu , Junru Cheng , Tian Guan , Yonghong He

Renal compartment segmentation on CT images targets on extracting the 3D structure of renal compartments from abdominal CTA images and is of great significance to the diagnosis and treatment for kidney diseases. However, due to the unclear…

Image and Video Processing · Electrical Eng. & Systems 2021-08-29 Song Wang , Yuting He , Youyong Kong , Xiaomei Zhu , Shaobo Zhang , Pengfei Shao , Jean-Louis Dillenseger , Jean-Louis Coatrieux , Shuo Li , Guanyu Yang

We propose a modular framework for predicting cancer specific survival directly from whole slide pathology images (WSIs). The framework consists of four key stages designed to capture prognostic and morphological heterogeneity. First, a…

Computer Vision and Pattern Recognition · Computer Science 2025-11-20 Ardhendu Sekhar , Vasu Soni , Keshav Aske , Garima Jain , Pranav Jeevan , Amit Sethi

Whole slide image (WSI) classification is a critical task in computational pathology. However, the gigapixel-size of such images remains a major challenge for the current state of deep-learning. Current methods rely on multiple-instance…

Computer Vision and Pattern Recognition · Computer Science 2023-10-04 Etienne Pochet , Rami Maroun , Roger Trullo

Computational pathology and whole-slide image (WSI) analysis are pivotal in cancer diagnosis and prognosis. However, the ultra-high resolution of WSIs presents significant modeling challenges. Recent advancements in pathology foundation…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Honglin Li , Zhongyi Shui , Yunlong Zhang , Chenglu Zhu , Lin Yang

Despite the recent advances of deep learning algorithms in medical imaging, the automatic segmentation algorithms for kidneys in MRI exams are still scarce. Automated segmentation of kidneys in Magnetic Resonance Imaging (MRI) exams are…

Image and Video Processing · Electrical Eng. & Systems 2021-08-31 Manu Goyal , Junyu Guo , Lauren Hinojosa , Keith Hulsey , Ivan Pedrosa

Hematoxylin- and eosin (H&E) stained whole-slide images (WSIs) are the foundation of diagnosis of cancer. In recent years, development of deep learning-based methods in computational pathology enabled the prediction of biomarkers directly…

Accurate nuclei segmentation in microscopy whole slide images (WSIs) remains challenging due to variability in staining, imaging conditions, and tissue morphology. We propose CellGenNet, a knowledge distillation framework for robust…

Computer Vision and Pattern Recognition · Computer Science 2025-11-20 Srijan Ray , Bikesh K. Nirala , Jason T. Yustein , Sundaresh Ram

Gastrointestinal (GI) tract cancers pose a global health challenge, demanding precise radiotherapy planning for optimal treatment outcomes. This paper introduces a cutting-edge approach to automate the segmentation of GI tract regions in…

Image and Video Processing · Electrical Eng. & Systems 2024-01-30 Ye Zhang , Yulu Gong , Dongji Cui , Xinrui Li , Xinyu Shen

Whole slide image (WSI) assessment is a challenging and crucial step in cancer diagnosis and treatment planning. WSIs require high magnifications to facilitate sub-cellular analysis. Precise annotations for patch- or even pixel-level…

Computer Vision and Pattern Recognition · Computer Science 2023-11-20 Simon Holdenried-Krafft , Peter Somers , Ivonne A. Montes-Majarro , Diana Silimon , Cristina Tarín , Falko Fend , Hendrik P. A. Lensch

Automated volumetric segmentation of the pancreas on cross-sectional imaging is needed for diagnosis and follow-up of pancreatic diseases. While CT-based pancreatic segmentation is more established, MRI-based segmentation methods are…

We propose an end-to-end neural network that improves the segmentation accuracy of fully convolutional networks by incorporating a localization unit. This network performs object localization first, which is then used as a cue to guide the…

Computer Vision and Pattern Recognition · Computer Science 2019-12-04 Zichen Zhang , Min Tang , Dana Cobzas , Dornoosh Zonoobi , Martin Jagersand , Jacob L. Jaremko

Simultaneous segmentation and classification of nuclei in digital histology play an essential role in computer-assisted cancer diagnosis; however, it remains challenging. The highest achieved binary and multi-class Panoptic Quality (PQ)…

Computer Vision and Pattern Recognition · Computer Science 2024-04-29 Ibtihaj Ahmad , Syed Muhammad Israr , Zain Ul Islam