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Understanding how the brain represents and processes information is crucial for advancing neuroscience and artificial intelligence. Representational similarity analysis (RSA) has been instrumental in characterizing neural representations,…

Neurons and Cognition · Quantitative Biology 2024-08-23 Baihan Lin

Representational Similarity Analysis (RSA) is a technique developed by neuroscientists for comparing activity patterns of different measurement modalities (e.g., fMRI, electrophysiology, behavior). As a framework, RSA has several advantages…

Computation and Language · Computer Science 2019-09-06 Mostafa Abdou , Artur Kulmizev , Felix Hill , Daniel M. Low , Anders Søgaard

Representational similarity analysis (RSA) has been shown to be an effective framework to characterize brain-activity profiles and deep neural network activations as representational geometry by computing the pairwise distances of the…

Neurons and Cognition · Quantitative Biology 2019-07-30 Baihan Lin , Marieke Mur , Tim Kietzmann , Nikolaus Kriegeskorte

Representational Similarity Analysis (RSA) is a popular method for analyzing neuroimaging and behavioral data. Here we evaluate the accuracy and reliability of RSA in the context of model selection, and compare it to that of regression.…

Methodology · Statistics 2025-11-18 Chuanji Gao , Gang Chen , Svetlana V. Shinkareva , Rutvik H. Desai

A central question for neuroscience is how to characterize brain representations of perceptual and cognitive content. An ideal characterization should distinguish different functional regions with robustness to noise and idiosyncrasies of…

Neurons and Cognition · Quantitative Biology 2024-10-17 Baihan Lin , Nikolaus Kriegeskorte

Representational similarity analysis (RSA) is a multivariate technique to investigate cortical representations of objects or constructs. While avoiding ill-posed matrix inversions that plague multivariate approaches in the presence of many…

Methodology · Statistics 2021-12-03 Roberto Viviani

Similarity measures are widely used to interpret the representational geometries used by neural networks to solve tasks. Yet, because existing methods compare the extrinsic geometry of representations in state space, rather than their…

Machine Learning · Computer Science 2026-04-03 N Alex Cayco-Gajic , Arthur Pellegrino

Similarity analysis is one of the crucial steps in most fMRI studies. Representational Similarity Analysis (RSA) can measure similarities of neural signatures generated by different cognitive states. This paper develops Deep…

Image and Video Processing · Electrical Eng. & Systems 2020-10-06 Muhammad Yousefnezhad , Jeffrey Sawalha , Alessandro Selvitella , Daoqiang Zhang

Representational similarity metrics are fundamental tools in neuroscience and AI, yet we lack systematic comparisons of their discriminative power across model families. We introduce a quantitative framework to evaluate representational…

Machine Learning · Computer Science 2025-12-10 Jialin Wu , Shreya Saha , Yiqing Bo , Meenakshi Khosla

Similarity metrics such as representational similarity analysis (RSA) and centered kernel alignment (CKA) have been used to compare layer-wise representations between neural networks. However, these metrics are confounded by the population…

Machine Learning · Statistics 2022-02-02 Tianyu Cui , Yogesh Kumar , Pekka Marttinen , Samuel Kaski

A multitude of (dis)similarity measures between neural network representations have been proposed, resulting in a fragmented research landscape. Most of these measures fall into one of two categories. First, measures such as linear…

Machine Learning · Statistics 2023-11-21 Sarah E. Harvey , Brett W. Larsen , Alex H. Williams

Representational Similarity Analysis (RSA) aims to explore similarities between neural activities of different stimuli. Classical RSA techniques employ the inverse of the covariance matrix to explore a linear model between the neural…

Neurons and Cognition · Quantitative Biology 2018-09-13 Xiaoliang Sheng , Muhammad Yousefnezhad , Tonglin Xu , Ning Yuan , Daoqiang Zhang

We present analytical expressions for the means and covariances of the sample distribution of the cross-validated Mahalanobis distance. This measure has proven to be especially useful in the context of representational similarity analysis…

Applications · Statistics 2016-07-06 Jörn Diedrichsen , Serge Provost , Hossein Zareamoghaddam

Decoding approaches are widely used in neuroscience and machine learning to compare stimulus representations across neural systems, such as different brain regions, organisms, and deep learning models. Popular methods include decoding…

Neurons and Cognition · Quantitative Biology 2026-05-08 Johannes Bertram , Luciano Dyballa , T. Anderson Keller , Savik Kinger , Steven W. Zucker

High-resolution functional imaging is providing increasingly rich measurements of brain activity in animals and humans. A major challenge is to leverage such data to gain insight into the brain's computational mechanisms. The first step is…

Neurons and Cognition · Quantitative Biology 2016-08-09 Nikolaus Kriegeskorte , Jörn Diedrichsen

Quantifying similarity between neural representations -- e.g. hidden layer activation vectors -- is a perennial problem in deep learning and neuroscience research. Existing methods compare deterministic responses (e.g. artificial networks…

Machine Learning · Computer Science 2023-02-07 Lyndon R. Duong , Jingyang Zhou , Josue Nassar , Jules Berman , Jeroen Olieslagers , Alex H. Williams

Methods for analyzing representations in neural systems have become a popular tool in both neuroscience and mechanistic interpretability. Having measures to compare how similar activations of neurons are across conditions, architectures,…

Machine Learning · Computer Science 2024-12-24 Quentin Guilhot , Michał Wójcik , Jascha Achterberg , Rui Ponte Costa

Activation-alignment measures such as Representational Similarity Analysis (RSA), Canonical Correlation Analysis (CCA), and Centered Kernel Alignment (CKA) are widely used to compare biological and artificial neural representations. Recent…

Machine Learning · Computer Science 2026-05-08 Amirhossein Yavari , Farnaz Zamani Esfahlani

In this paper, we define and apply representational stability analysis (ReStA), an intuitive way of analyzing neural language models. ReStA is a variant of the popular representational similarity analysis (RSA) in cognitive neuroscience.…

Artificial Intelligence · Computer Science 2019-06-06 Samira Abnar , Lisa Beinborn , Rochelle Choenni , Willem Zuidema

As regression is a widely studied problem, many methods have been proposed to solve it, each of them often requiring setting different hyper-parameters. Therefore, selecting the proper method for a given application may be very difficult…

Machine Learning · Computer Science 2026-03-23 Nassime Mountasir , Baptiste Lafabregue , Bruno Albert , Nicolas Lachiche
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