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Genetic risk prediction is an important component of individualized medicine, but prediction accuracies remain low for many complex diseases. A fundamental limitation is the sample sizes of the studies on which the prediction algorithms are…

Methodology · Statistics 2017-06-20 Sihai Dave Zhao

Variational auto-encoders (VAE) are popular deep latent variable models which are trained by maximizing an Evidence Lower Bound (ELBO). To obtain tighter ELBO and hence better variational approximations, it has been proposed to use…

Machine Learning · Statistics 2021-07-22 Achille Thin , Nikita Kotelevskii , Arnaud Doucet , Alain Durmus , Eric Moulines , Maxim Panov

Deep neural networks (DNNs) are vulnerable to adversarial examples that are carefully designed to cause the deep learning model to make mistakes. Adversarial examples of 2D images and 3D point clouds have been extensively studied, but…

Computer Vision and Pattern Recognition · Computer Science 2021-12-28 Wooju Lee , Hyun Myung

Unlearnable examples (UEs) seek to maximize testing error by making subtle modifications to training examples that are correctly labeled. Defenses against these poisoning attacks can be categorized based on whether specific interventions…

Cryptography and Security · Computer Science 2024-05-07 Yi Yu , Yufei Wang , Song Xia , Wenhan Yang , Shijian Lu , Yap-Peng Tan , Alex C. Kot

Postmarketing safety surveillance relies on data from spontaneous reporting systems (SRS) such as FAERS, EudraVigilance and VigiBase, and commonly uses SRS data mining methods to assess the associations between drugs and adverse events…

Applications · Statistics 2026-04-29 Yihao Tan , Marianthi Markatou , Saptarshi Chakraborty

Detectors in next-generation high-energy physics experiments face several daunting requirements, such as high data rates, damaging radiation exposure, and stringent constraints on power, space, and latency. To address these challenges,…

Data Analysis, Statistics and Probability · Physics 2025-08-18 Alexander Yue , Haoyi Jia , Julia Gonski

We present our solution for the EvalRS DataChallenge. The EvalRS DataChallenge aims to build a more realistic recommender system considering accuracy, fairness, and diversity in evaluation. Our proposed system is based on an ensemble…

Information Retrieval · Computer Science 2022-11-03 Jinhyeok Park , Dain Kim , Dongwoo Kim

Researchers require timely access to real-world longitudinal electronic health records (EHR) to develop, test, validate, and implement machine learning solutions that improve the quality and efficiency of healthcare. In contrast, health…

Machine Learning · Computer Science 2020-12-21 Siddharth Biswal , Soumya Ghosh , Jon Duke , Bradley Malin , Walter Stewart , Jimeng Sun

Variational autoencoders (VAEs), as well as other generative models, have been shown to be efficient and accurate for capturing the latent structure of vast amounts of complex high-dimensional data. However, existing VAEs can still not…

Machine Learning · Computer Science 2020-05-25 Alfredo Nazabal , Pablo M. Olmos , Zoubin Ghahramani , Isabel Valera

Safety-critical domains like healthcare rely on deep neural networks (DNNs) for prediction, yet DNNs remain vulnerable to evasion attacks. Anomaly detectors (ADs) are widely used to protect DNNs, but conventional ADs are trained…

Cryptography and Security · Computer Science 2026-04-20 Mohammed Elnawawy , Gargi Mitra , Shahrear Iqbal , Karthik Pattabiraman

Developing accurate and reliable methods to estimate vaccine protection is a key goal in immunology and public health. While several statistical methods have been proposed, their potential inaccuracy in capturing fast intra-seasonal waning…

Quantitative Methods · Quantitative Biology 2022-05-26 Ariel Nikas , Hasan Ahmed , Veronika I. Zarnitsyna

Anomaly detection in imbalanced datasets is a frequent and crucial problem, especially in the medical domain where retrieving and labeling irregularities is often expensive. By combining the generative stability of a $\beta$-variational…

Machine Learning · Computer Science 2023-10-30 Fiete Lüer , Tobias Weber , Maxim Dolgich , Christian Böhm

In recent years, Deep Neural Networks (DNNs) have become increasingly integral to IoT-based environments, enabling realtime visual computing. However, the limited computational capacity of these devices has motivated the adoption of…

Cryptography and Security · Computer Science 2026-04-29 Shima Yousefi , Motahare Mounesan , Saptarshi Debroy

Recently, a generative variational autoencoder (VAE) has been proposed for speech enhancement to model speech statistics. However, this approach only uses clean speech in the training phase, making the estimation particularly sensitive to…

Audio and Speech Processing · Electrical Eng. & Systems 2021-05-18 Huajian Fang , Guillaume Carbajal , Stefan Wermter , Timo Gerkmann

Gravitational waves (GW), predicted by Einstein's General Theory of Relativity, provide a powerful probe of astrophysical phenomena and fundamental physics. In this work, we propose an unsupervised anomaly detection method using variational…

General Relativity and Quantum Cosmology · Physics 2024-12-17 Ammar Fayad

The surrogate loss of variational autoencoders (VAEs) poses various challenges to their training, inducing the imbalance between task fitting and representation inference. To avert this, the existing strategies for VAEs focus on adjusting…

Neural and Evolutionary Computing · Computer Science 2024-04-02 Zhangkai Wu , Longbing Cao , Lei Qi

Variational Autoencoders (VAEs) have gained significant popularity among researchers as a powerful tool for understanding unknown distributions based on limited samples. This popularity stems partly from their impressive performance and…

Machine Learning · Computer Science 2024-02-27 Saptarshi Chakraborty , Peter L. Bartlett

Unsupervised learning can leverage large-scale data sources without the need for annotations. In this context, deep learning-based autoencoders have shown great potential in detecting anomalies in medical images. However, especially…

Image and Video Processing · Electrical Eng. & Systems 2020-01-03 David Zimmerer , Simon Kohl , Jens Petersen , Fabian Isensee , Klaus Maier-Hein

The safety of medical products continues to be a significant health concern worldwide. Spontaneous reporting systems (SRS) and pharmacovigilance databases are essential tools for postmarketing surveillance of medical products. Various SRS…

Computation · Statistics 2024-10-03 Anran Liu , Raktim Mukhopadhyay , Marianthi Markatou

Deep networks often make confident, yet, incorrect, predictions when tested with outlier data that is far removed from their training distributions. Likelihoods computed by deep generative models (DGMs) are a candidate metric for outlier…

Machine Learning · Computer Science 2022-07-20 Kushal Chauhan , Barath Mohan U , Pradeep Shenoy , Manish Gupta , Devarajan Sridharan
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