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There have been several attempts to use deep learning based on brain fMRI signals to classify cognitive impairment diseases. However, deep learning is a hidden black box model that makes it difficult to interpret the process of…

Machine Learning · Computer Science 2024-11-20 Jeong-Jae Kim , Yeseul Jeon , SuMin Yu , Junggu Choi , Sanghoon Han

Large efforts are currently under way to systematically map functional connectivity between all pairs of millimeter-scale brain regions using big volumes of neuroimaging data. Functional magnetic resonance imaging (fMRI) can produce these…

Neurons and Cognition · Quantitative Biology 2014-09-24 Enzo Tagliazucchi , Helmut Laufs , Dante R. Chialvo

Internal representations within deep neural architectures encode high-dimensional abstractions of linguistic structures, yet they often exhibit inefficiencies in feature distribution, limiting expressiveness and adaptability. Contextual…

Computation and Language · Computer Science 2025-03-27 Alistair Wren , Beatrice Loxley , Hamish Cadwallader , Simon Beckwith , Fabian Pargeter , James Blades

Cognitive neuroscience is enjoying rapid increase in extensive public brain-imaging datasets. It opens the door to large-scale statistical models. Finding a unified perspective for all available data calls for scalable and automated…

Machine Learning · Statistics 2019-05-16 Arthur Mensch , Julien Mairal , Danilo Bzdok , Bertrand Thirion , Gaël Varoquaux

Recent advancements in the acquisition of various brain data sources have created new opportunities for integrating multimodal brain data to assist in early detection of complex brain disorders. However, current data integration approaches…

Image and Video Processing · Electrical Eng. & Systems 2023-05-26 Reza Shirkavand , Liang Zhan , Heng Huang , Li Shen , Paul M. Thompson

This paper aims to investigate the distributed stochastic optimization problems on compact embedded submanifolds (in the Euclidean space) for multi-agent network systems. To address the manifold structure, we propose a distributed…

Optimization and Control · Mathematics 2025-10-28 Jishu Zhao , Xi Wang , Jinlong Lei , Shixiang Chen

Natural human interactions for Mixed Reality Applications are overwhelmingly multimodal: humans communicate intent and instructions via a combination of visual, aural and gestural cues. However, supporting low-latency and accurate…

Human-Computer Interaction · Computer Science 2020-12-21 Darshana Rathnayake , Ashen de Silva , Dasun Puwakdandawa , Lakmal Meegahapola , Archan Misra , Indika Perera

We construct embedded functional connectivity networks (FCN) from benchmark resting-state functional magnetic resonance imaging (rsfMRI) data acquired from patients with schizophrenia and healthy controls based on linear and nonlinear…

Neurons and Cognition · Quantitative Biology 2023-03-24 Ioannis Gallos , Evangelos Galaris , Constantinos Siettos

Data-Driven Computational Mechanics is a novel computing paradigm that enables the transition from standard data-starved approaches to modern data-rich approaches. At this early stage of development, one can distinguish two mainstream…

Numerical Analysis · Mathematics 2019-10-29 Cristian Guillermo Gebhardt , Dominik Schillinger , Marc Christian Steinbach , Raimund Rolfes

Machine learning has become integral to medical research and is increasingly applied in clinical settings to support diagnosis and decision-making; however, its effectiveness depends on access to large, diverse datasets, which are limited…

Machine Learning · Computer Science 2026-04-21 Ke Wan , Kensuke Tanioka , Toshio Shimokawa

Recent advances in deep learning have made it possible to predict phenotypic measures directly from functional magnetic resonance imaging (fMRI) brain volumes, sparking significant interest in the neuroimaging community. However, existing…

Computer Vision and Pattern Recognition · Computer Science 2025-07-01 Arunkumar Kannan , Martin A. Lindquist , Brian Caffo

Functional Magnetic Resonance Imaging (fMRI) captures the temporal dynamics of neural activity as a function of spatial location in the brain. Thus, fMRI scans are represented as 4-Dimensional (3-space + 1-time) tensors. And it is widely…

Computer Vision and Pattern Recognition · Computer Science 2020-02-17 Ahmed El-Gazzar , Mirjam Quaak , Leonardo Cerliani , Peter Bloem , Guido van Wingen , Rajat Mani Thomas

Functional magnetic resonance imaging (fMRI) is a powerful tool for probing brain function, yet reliable clinical diagnosis is hampered by low signal-to-noise ratios, inter-subject variability, and the limited frequency awareness of…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Junhao Jia , Yifei Sun , Yunyou Liu , Cheng Yang , Changmiao Wang , Feiwei Qin , Yong Peng , Wenwen Min

Multi-modal MRIs are widely used in neuroimaging applications since different MR sequences provide complementary information about brain structures. Recent works have suggested that multi-modal deep learning analysis can benefit from…

Computer Vision and Pattern Recognition · Computer Science 2021-06-14 Jiahong Ouyang , Ehsan Adeli , Kilian M. Pohl , Qingyu Zhao , Greg Zaharchuk

This paper introduces a unifying framework that links the Context-Content Uncertainty Principle (CCUP) with optimal transport (OT) via primal-dual inference. We propose that cognitive representations are not static encodings but active dual…

Neurons and Cognition · Quantitative Biology 2025-06-19 Xin Li

Contemporary computational neuroscience features two prominent modeling traditions. Bottom-up whole-brain modeling (WBM) builds biophysically detailed simulations of brain structure and dynamics, whereas top-down neuroconnectionism…

Neurons and Cognition · Quantitative Biology 2026-05-19 Mario Senden , Leonardo Dalla Porta , Jan Fousek , Jorge F. Mejias , Gorka Zamora-López

Analysis of brain connectivity is important for understanding how information is processed by the brain. We propose a novel Bayesian vector autoregression (VAR) hierarchical model for analyzing brain connectivity in a resting-state fMRI…

Applications · Statistics 2021-12-09 Bertil Wegmann , Anders Lundquist , Anders Eklund , Mattias Villani

We introduce a reproducible, bias-resistant machine learning framework that integrates domain-informed feature engineering, nested cross-validation, and calibrated decision-threshold optimization for small-sample neuroimaging data.…

Machine Learning · Computer Science 2026-02-04 Jagan Mohan Reddy Dwarampudi , Jennifer L Purks , Joshua Wong , Renjie Hu , Tania Banerjee

Cancer diagnosis, prognosis, and therapeutic response predictions are based on morphological information from histology slides and molecular profiles from genomic data. However, most deep learning-based objective outcome prediction and…

Computer Vision and Pattern Recognition · Computer Science 2020-09-04 Richard J. Chen , Ming Y. Lu , Jingwen Wang , Drew F. K. Williamson , Scott J. Rodig , Neal I. Lindeman , Faisal Mahmood

Integrating brain imaging data with clinical reports offers a valuable opportunity to leverage complementary multimodal information for more effective and timely diagnosis in practical clinical settings. This approach has gained significant…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Jing Zhang , Xiaowei Yu , Minheng Chen , Lu Zhang , Tong Chen , Yan Zhuang , Chao Cao , Yanjun Lyu , Li Su , Tianming Liu , Dajiang Zhu