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This work describes a hyperbolic model for cell-cell repulsion with population dynamics. We consider the pressure produced by a population of cells to describe their motion. We assume that cells try to avoid crowded areas and prefer locally…

Analysis of PDEs · Mathematics 2024-05-24 Quentin Griette , Pierre Magal , Min Zhao

We study a two-dimensional free boundary problem that models motility of eukaryotic cells on substrates. This problem consists of an elliptic equation describing the flow of cytoskeleton gel coupled with a convection-diffusion PDE for the…

Analysis of PDEs · Mathematics 2017-07-12 Leonid Berlyand , Jan Fuhrmann , Volodymyr Rybalko

How can repulsive and attractive forces, acting on a conservative system, create stable traveling patterns or branching instabilities? We have proposed to study this question in the framework of the hyperbolic Keller-Segel system with…

Pattern Formation and Solitons · Physics 2015-05-20 Benoit Perthame , Christian Schmeiser , Min Tang , Nicolas Vauchelet

We study an incompressible Darcy's free boundary problem, recently introduced in [22]. Our goal is to prove the existence of non-trivial traveling wave solutions and thus validate the interest of this model to describe cell motility. The…

Analysis of PDEs · Mathematics 2022-05-10 Thomas Alazard , Martina Magliocca , Nicolas Meunier

This letter is concerned with asymptotic analysis of a PDE model for motility of a eukaryotic cell on a substrate. This model was introduced in [1], where it was shown numerically that it successfully reproduces experimentally observed…

Analysis of PDEs · Mathematics 2016-04-12 Leonid Berlyand , Mykhailo Potomkin , Volodymyr Rybalko

We are concerned with the hyperbolic Keller-Segel model with quorum sensing, a model describing the collective cell movement due to chemical signalling with a flux limitation for high cell densities. This is a first order quasilinear…

Analysis of PDEs · Mathematics 2007-05-23 Benoit Perthame , Anne-Laure Dalibard

We introduce a two-dimensional Hele-Shaw type free boundary model for motility of eukaryotic cells on substrates. The key ingredients of this model are the Darcy law for overdamped motion of the cytoskeleton gel (active gel) coupled with…

Analysis of PDEs · Mathematics 2021-04-02 Volodymyr Rybalko , Leonid Berlyand

We study a non-linear and non-local evolution equation for curves obtained as the sharp interface limit of a phase-field model for crawling motion of eukaryotic cells on a substrate. We establish uniqueness of solutions to the sharp…

Analysis of PDEs · Mathematics 2017-03-03 Matthew S. Mizuhara , Peng Zhang

We consider the Keller-Segel model for chemotaxis with a nonlinear diffusion coefficent and a singular sensitivity function. We show the existence of travelling waves for wave speeds above a critical value, and establish local…

Analysis of PDEs · Mathematics 2012-02-20 Martin Meyries

The existence of travelling waves for a coupled system of hyperbolic/ parabolic equations is established in the case of a finite number of velocities in the kinetic equation. This finds application in collective motion of chemotactic…

Analysis of PDEs · Mathematics 2018-11-20 Vincent Calvez , Laurent Gosse , Monika Twarogowska

We introduce a two-dimensional Keller-Segel type free boundary model for motility of eukaryotic cells on substrates. The key ingredients of this model are the Darcy law for overdamped motion of the cytoskeleton (active) gel and Hele-Shaw…

Analysis of PDEs · Mathematics 2019-07-30 Leonid Berlyand , Volodymyr Rybalko

This paper investigates an initial-Neumann boundary value problem for a Keller--Segel system with parabolic-parabolic-ODE coupling. The model incorporates a signal-dependent, non-increasing motility function that, through indirect signal…

Analysis of PDEs · Mathematics 2026-04-13 Yujiao Sun , Jie Jiang

We consider a free boundary model of epithelial cell migration with logistic growth and nonlinear diffusion induced by mechanical interactions. Using numerical simulations, phase plane and perturbation analysis, we find and analyse…

Pattern Formation and Solitons · Physics 2020-10-05 Ryan J Murphy , Pascal R Buenzli , Ruth E Baker , Matthew J Simpson

We perform the analysis of a hyperbolic model which is the analog of the Fisher-KPP equation. This model accounts for particles that move at maximal speed $\epsilon^{-1}$ ($\epsilon\textgreater{}0$), and proliferate according to a reaction…

Analysis of PDEs · Mathematics 2016-11-22 Emeric Bouin , Vincent Calvez , Grégoire Nadin

In this study, we analyze the behavior of monotone traveling waves of a one-dimensional porous medium equation modeling mechanical properties of living tissues. We are interested in the asymptotics where the pressure, which governs the…

Analysis of PDEs · Mathematics 2021-08-25 Anne-Laure Dalibard , Gabriela Lopez-Ruiz , Charlotte Perrin

We investigate the point spectrum associated with travelling wave solutions in a Keller-Segel model for bacterial chemotaxis with small diffusivity of the chemoattractant, a logarithmic chemosensitivity function and a constant, sublinear or…

Spectral Theory · Mathematics 2017-12-01 P. N. Davis , P. van Heijster , R. Marangell

We investigate a minimal model for cell propagation involving migration along self-generated signaling gradients and cell division, which has been proposed in an earlier study. The model consists in a system of two coupled parabolic…

Analysis of PDEs · Mathematics 2022-03-11 Mete Demircigil

In this work, we discuss a cell-cell repulsion population dynamic model based on a hyperbolic Keller-Segel equation with two populations. This model can well describe the cell growth and dispersion in the cell co-culture experiment in the…

Analysis of PDEs · Mathematics 2019-07-26 Xiaoming Fu , Quentin Griette , Pierre Magal

In this paper, we present a cell motility model that takes into account the cell membrane effect. The model introduced is an incompressible Darcy free boundary problem. This model involves a nonlinear term in the boundary condition to model…

Analysis of PDEs · Mathematics 2025-01-09 Claire Alamichel , Nicolas Meunier

We show that there exist traveling wave solutions of the Keller-Segel-FKPP equation, which models a diffusing and logistically growing population subject to chemotaxis. In contrast to previous results, our result is in the strong…

Analysis of PDEs · Mathematics 2023-10-24 Christopher Henderson , Maximilian Rezek
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