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The problem of detecting changes in covariance for a single pair of features has been studied in some detail, but may be limited in importance or general applicability. In contrast, testing equality of covariance matrices of a {\it set} of…

Methodology · Statistics 2017-12-12 Yi-Hui Zhou

Hotelling's $T^2$ test is a classical approach for discriminating the means of two multivariate normal samples that share a population covariance matrix. Hotelling's test is not ideal for high-dimensional samples because the eigenvalues of…

Statistics Theory · Mathematics 2022-06-07 Benjamin D. Robinson , Robert Malinas , Van Latimer , Beth Bjorkman Morrison , Alfred O. Hero

Two-sample tests for multivariate data and non-Euclidean data are widely used in many fields. Parametric tests are mostly restrained to certain types of data that meets the assumptions of the parametric models. In this paper, we study a…

Methodology · Statistics 2018-05-01 Hao Chen , Xu Chen , Yi Su

We propose a method of testing the shift between mean vectors of two multivariate Gaussian random variables in a high-dimensional setting incorporating the possible dependency and allowing $p > n$. This method is a combination of two…

Methodology · Statistics 2019-12-24 Tzviel Frostig , Yoav Benjamini

Valid estimation of treatment effects from observational data requires proper control of confounding. If the number of covariates is large relative to the number of observations, then controlling for all available covariates is infeasible.…

Methodology · Statistics 2018-01-11 Joseph Antonelli , Matthew Cefalu , Nathan Palmer , Denis Agniel

We propose a two-sample test for the means of high-dimensional data when the data dimension is much larger than the sample size. Hotelling's classical $T^2$ test does not work for this "large $p$, small $n$" situation. The proposed test…

Statistics Theory · Mathematics 2010-02-25 Song Xi Chen , Ying-Li Qin

With the extensive use of digital devices, online experimental platforms are commonly used to conduct experiments to collect data for evaluating different variations of products, algorithms, and interface designs, a.k.a., A/B tests. In…

Methodology · Statistics 2024-07-09 Qiong Zhang , Lulu Kang , Xinwei Deng

Hotelling's $T^2$-test for the mean of a multivariate normal distribution is one of the triumphs of classical multivariate analysis. It is uniformly most powerful among invariant tests, and admissible, proper Bayes, and locally and…

Statistics Theory · Mathematics 2019-10-10 Michael D. Perlman

Mantel's test (MT) for association is conducted by testing the linear relationship of similarity of all pairs of subjects between two observational domains. Motivated by applications to neuroimaging and genetics data, and following the…

Methodology · Statistics 2018-12-18 Dustin Pluta , Hernando Ombao , Chuansheng Chen , Gui Xue , Robert Moyzis , Zhaoxia Yu

Repeated observations have become increasingly common in biomedical research and longitudinal studies. For instance, wearable sensor devices are deployed to continuously track physiological and biological signals from each individual over…

Applications · Statistics 2021-06-25 Jingru Zhang , Kathleen R. Merikangas , Hongzhe Li , Haochang Shou

Matching is a widely used causal inference design that aims to approximate a randomized experiment using observational data by forming matched sets of treated and control units based on similarities in their covariates. Ideally, treated…

Methodology · Statistics 2026-04-06 Jianan Zhu , Jeffrey Zhang , Zijian Guo , Siyu Heng

Missing data is a common issue in many biomedical studies. Under a paired design, some subjects may have missing values in either one or both of the conditions due to loss of follow-up, insufficient biological samples, etc. Such partially…

Thanks to high-tech measurement systems like sensors, data are often collected with high frequency in modern industrial processes. This phenomenon could potentially produce autocorrelated and cross-correlated measurements. It has been shown…

Methodology · Statistics 2025-01-22 Adel Ahmadi Nadi , Giovanni Celano , Stefan Steiner

Not many tests exist for testing the equality for two or more multivariate distributions with compositional data, perhaps due to their constrained sample space. At the moment, there is only one test suggested that relies upon random…

Methodology · Statistics 2025-12-12 Volkan Sevinc , Michail Tsagris

We consider the problem of testing whether pairs of univariate random variables are associated. Few tests of independence exist that are consistent against all dependent alternatives and are distribution free. We propose novel tests that…

Methodology · Statistics 2014-12-09 Ruth Heller , Yair Heller , Shachar Kaufman , Malka Gorfine

In this paper, we propose a new test for testing the equality of two population covariance matrices in the ultra-high dimensional setting that the dimension is much larger than the sizes of both of the two samples. Our proposed methodology…

Methodology · Statistics 2023-12-19 Xiucai Ding , Yichen Hu , Zhenggang Wang

We present a new experimental design procedure that divides a set of experimental units into two groups in order to minimize error in estimating an additive treatment effect. One concern is minimizing error at the experimental design stage…

Methodology · Statistics 2021-02-02 Abba M. Krieger , David Azriel , Adam Kapelner

Hotelling's T-squared test is a classical tool to test if the normal mean of a multivariate normal distribution is a specified one or the means of two multivariate normal means are equal. When the population dimension is higher than the…

Statistics Theory · Mathematics 2021-08-17 Tiefeng Jiang , Ping Li

Many experimental paradigms in neuroscience involve driving the nervous system with periodic sensory stimuli. Neural signals recorded using a variety of techniques will then include phase-locked oscillations at the stimulation frequency.…

Methodology · Statistics 2021-08-30 Daniel H. Baker

Comparing two population means of network data is of paramount importance in a wide range of scientific applications. Many existing network inference solutions focus on global testing of entire networks, without comparing individual network…

Methodology · Statistics 2019-10-10 Yin Xia , Lexin Li