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In this study, we explored the use of spectrograms to represent handwriting signals for assessing neurodegenerative diseases, including 42 healthy controls (CTL), 35 subjects with Parkinson's Disease (PD), 21 with Alzheimer's Disease (AD),…

Machine Learning · Computer Science 2025-02-12 Sarah Laouedj , Yuzhe Wang , Jesus Villalba , Thomas Thebaud , Laureano Moro-Velazquez , Najim Dehak

At present, the vast majority of human subjects with neurological disease are still diagnosed through in-person assessments and qualitative analysis of patient data. In this paper, we propose to use Topological Data Analysis (TDA) together…

Machine Learning · Computer Science 2020-05-07 Afra Nawar , Farhan Rahman , Narayanan Krishnamurthi , Anirudh Som , Pavan Turaga

Alzheimer's Disease is the most common cause of dementia. Accurate diagnosis and prognosis of this disease are essential to design an appropriate treatment plan, increasing the life expectancy of the patient. Intense research has been…

Image and Video Processing · Electrical Eng. & Systems 2023-01-05 Huy-Dung Nguyen , Michaël Clément , Boris Mansencal , Pierrick Coupé

We propose a novel algorithm called Unique Brain Network Identification Number, UBNIN for encoding the brain networks of individual subjects. To realize this objective, we employed structural MRI on 180 Parkinsons disease PD patients and 70…

Image and Video Processing · Electrical Eng. & Systems 2023-09-20 Tanmayee Samantaray , Utsav Gupta , Jitender Saini , Cota Navin Gupta

In this study we focus on the diagnosis of Parkinson's Disease (PD) based on electroencephalogram (EEG) signals. We propose a new approach inspired by the functioning of the brain that uses the dynamics, frequency and temporal content of…

Systems and Control · Electrical Eng. & Systems 2023-03-31 Houssem Meghnoudj , Bogdan Robu , Mazen Alamir

Multiscale modelling presents a multifaceted perspective into understanding the mechanisms of the brain and how neurodegenerative disorders like Parkinson's disease (PD) manifest and evolve over time. In this study, we propose a novel…

Neurons and Cognition · Quantitative Biology 2025-09-18 Aaron Herrera , Hina Shaheen

Thresholding of networks has long posed a challenge in brain connectivity analysis. Weighted networks are typically binarized using threshold measures to facilitate network analysis. Previous studies on MRI-based brain networks have…

Image and Video Processing · Electrical Eng. & Systems 2024-03-28 Tanmayee Samantaray , Jitender Saini , Pramod Kumar Pal , Bithiah Grace Jaganathan , Vijaya V Saradhi , Gupta CN

Alzheimer's Disease (AD) is a progressive neurodegenerative disease. Amnestic mild cognitive impairment (MCI) is a common first symptom before the conversion to clinical impairment where the individual becomes unable to perform activities…

Computer Vision and Pattern Recognition · Computer Science 2017-10-16 Donghuan Lu , Karteek Popuri , Weiguang Ding , Rakesh Balachandar , Mirza Faisal Beg

In the past few years, there are several researches on Parkinson's disease (PD) recognition using single-photon emission computed tomography (SPECT) images with deep learning (DL) approach. However, the DL model's complexity usually results…

Image and Video Processing · Electrical Eng. & Systems 2021-05-05 Theerasarn Pianpanit , Sermkiat Lolak , Phattarapong Sawangjai , Thapanun Sudhawiyangkul , Theerawit Wilaiprasitporn

One major challenge in the medication of Parkinson's disease is that the severity of the disease, reflected in the patients' motor state, cannot be measured using accessible biomarkers. Therefore, we develop and examine a variety of…

Machine Learning · Computer Science 2019-04-26 Jann Goschenhofer , Franz MJ Pfister , Kamer Ali Yuksel , Bernd Bischl , Urban Fietzek , Janek Thomas

Parkinson's disease is a neurodegenerative disorder that can be very tricky to diagnose and treat. Such early symptoms can include tremors, wheezy breathing, and changes in voice quality as critical indicators of neural damage. Notably,…

Sound · Computer Science 2025-11-20 Abishek Karthik , Pandiyaraju V , Dominic Savio M , Rohit Swaminathan S

Accurate early diagnosis and monitoring of neurodegenerative conditions is essential for effective disease management and delivery of medication and treatment. This research develops automatic methods for detecting brain imaging preclinical…

Neural and Evolutionary Computing · Computer Science 2019-10-15 Amir Dehsarvi , Stephen L. Smith

There is a need for automatic diagnosis of certain diseases from medical images that could help medical practitioners for further assessment towards treating the illness. Alzheimers disease is a good example of a disease that is often…

Image and Video Processing · Electrical Eng. & Systems 2019-01-30 GuruRaj Awate

This paper deals with a complex acoustic analysis of phonation in patients with Parkinson's disease (PD) with a special focus on estimation of disease progress that is described by 7 different clinical scales ,e. g. Unified Parkinson's…

Longitudinal voice biomarkers provide a non-invasive source of information for monitoring Parkinson's disease progression, but their statistical analysis is difficult because repeated measurements from the same subject are correlated,…

Machine Learning · Statistics 2026-04-28 Ran Tong , Lanruo Wang , Tong Wang , Wei Yan

Alzheimer's disease is a human brain disease that affects a significant fraction of the population by causing problems with short-term memory, thinking, spatial orientation and behavior, memory loss and other intellectual abilities. Up to…

Neurons and Cognition · Quantitative Biology 2012-10-02 Athanasios Alexiou , Panayiotis Vlamos

Alzheimer's disease (AD) is one of the most common public health issues the world is facing today. This disease has a high prevalence primarily in the elderly accompanying memory loss and cognitive decline. AD detection is a challenging…

Image and Video Processing · Electrical Eng. & Systems 2022-04-04 Zahraa Sh. Aaraji , Hawraa H. Abbas

Alzheimer's disease (AD) is a progressive and incurable neurodegenerative disease which destroys brain cells and causes loss to patient's memory. An early detection can prevent the patient from further damage of the brain cells and hence…

Image and Video Processing · Electrical Eng. & Systems 2021-01-11 Ali Nawaz , Syed Muhammad Anwar , Rehan Liaqat , Javid Iqbal , Ulas Bagci , Muhammad Majid

This study addresses the challenges of symptom evolution complexity and insufficient temporal dependency modeling in Parkinson's disease progression prediction. It proposes a unified prediction framework that integrates structural…

Machine Learning · Computer Science 2025-08-22 Jiacheng Hu , Bo Zhang , Ting Xu , Haifeng Yang , Min Gao

Parkinson's Disease (PD) is a neurodegenerative disease that currently does not have a cure. In order to facilitate disease management and reduce the speed of symptom progression, early diagnosis is essential. The current clinical,…

Image and Video Processing · Electrical Eng. & Systems 2019-09-11 Justin Quan , Lin Xu , Rene Xu , Tyrael Tong , Jean Su