Related papers: Computing extracellular electric potentials from n…

In recent years, extracellular vesicles such have become promising carriers as the next-generation drug delivery platforms. Effective loading of exogenous cargos without compromising the extracellular vesicle membrane is a major challenge.…

It is well known that Electroencephalography(EEG) and the respective evoked potentials have deep implications corresponding to specific cognitive tasks and in the diagnosis of several diseases such as epilepsy and schizophrenia. Some recent…

In this paper we present a computational model which decodes the spatio-temporal data from electro-physiological measurements of neuronal networks and reconstructs the network structure on a macroscopic domain, representing the connectivity…

Excitable tissue is fundamental to brain function, yet its study is complicated by extreme morphological complexity and the physiological processes governing its dynamics. Consequently, detailed computational modeling of this tissue…

The current-voltage (I-V) conversion characterizes the physiology of cellular microdomains and reflects cellular communication, excitability, and electrical transduction. Yet deriving such I-V laws remains a major challenge in most cellular…

The distribution of voltage in sub-micron cellular domains remains poorly understood. In neurons, the voltage results from the difference in ionic concentrations which are continuously maintained by pumps and exchangers. However, it not…

Directing extracellular vesicles (EVs), such as exosomes and microvesicles, toward specific cells is an emerging focus in nanomedicine, owing to their natural role as carriers of proteins, RNAs, and drugs. EVs can be manipulated by external…

Volume transmission is an important neural communication pathway in which neurons in one brain region influence the neurotransmitter concentration in the extracellular space of a distant brain region. In this paper, we apply asymptotic…

This is an early but comprehensive review of the PNP Poisson Nernst Planck theory of ion channels. Extensive reference is made to the earlier literature. The starting place for this theory of open channels is a theory of electrodiffusion…

In neuroelectrophysiology one records electric potentials or magnetic fields generated by ensembles of synchronously active neurons in response to externally presented stimuli. These evoked responses are often produced by multiple…

The excitability property of spiking neurons describes their capability to output an action potential as a real-time response to an input synaptic excitation current and is central to the event-based neuromorphic computing paradigm. The…

Extracellular electrical potentials (EEP) recorded from the brain are an active manifestation of all cellular processes that propagate within a volume of brain tissue. A standard approach for their quantification are power spectral analyses…

Electroencephalography (EEG) monitors ---by either intrusive or noninvasive electrodes--- time and frequency variations and spectral content of voltage fluctuations or waves, known as brain rhythms, which in some way uncover activity during…

Neurons in the nervous system are submitted to distinct sources of noise, such as ionic-channel and synaptic noise, which introduces variability in their responses to repeated presentations of identical stimuli. This motivates the use of…

We extend the scope of the dynamical theory of extreme values to cover phenomena that do not happen instantaneously, but evolve over a finite, albeit unknown at the onset, time interval. We consider complex dynamical systems, composed of…

Numerical investigation of the interaction of electromagnetic fields with eukaryotic cells requires specifically adapted computer models. Virtual microdosimetry, used to investigate exposure, requires volumetric cell models, which are…

Correlating neural communication in brain networks with behavior and cognition can provide fundamental insights into the functionality of both healthy and diseased brains. We demonstrate how communication in the brain can be estimated from…

Neurophysiologists are nowadays able to record from a large number of extracellular electrodes and to extract, from the raw data, the sequences of action potentials or spikes generated by many neurons. Unfortunately these ''many neurons''…

A common factor across electromagnetic methodologies of brain stimulation is the optimization of essential dosimetry parameters, like amplitude, phase, and location of one or more transducers, which controls the stimulation strength and…

Objective: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique used to generate conduction currents in the head and disrupt brain functions. To rapidly evaluate the tDCS-induced current density in…