Related papers: A parabolic free boundary problem arising in a mod…
We consider a parabolic non-local free boundary problem that has been derived as a limit of a bulk-surface reaction-diffusion system which models cell polarization. The authors have justified the well-posedness of this problem and have…
We consider a coupled bulk-surface system of partial differential equations with nonlinear coupling modelling receptor-ligand dynamics. The model arises as a simplification of a mathematical model for the reaction between cell surface…
We propose a model for cell polarization as a response to an external signal which results in a system of PDEs for different variants of a protein on the cell surface and interior respectively. We study stationary states of this model in…
We consider a parabolic non-local free boundary problem that has been derived as a limit of a bulk-surface reaction-diffusion system which models cell polarization. In previous papers, we have established well-posedness of this problem and…
In this paper, we consider a model with tumor microenvironment involving nutrient density, extracellular matrix and matrix-degrading enzymes, which satisfy a coupled system of PDEs with a free boundary. For this coupled parabolic-hyperbolic…
We derive various novel free boundary problems as limits of a coupled bulk-surface reaction-diffusion system modelling ligand-receptor dynamics on evolving domains. These limiting free boundary problems may be formulated as Stefan-type…
This paper studies asymptotic behavior of solutions of a free boundary problem modeling the growth of tumors with two species of cells: proliferating cells and quiecent cells. In previous literatures it has been proved that this problem has…
In this paper we study a mass-constrained free boundary problem modeling cell polarization, in the regime where the mass is small. In the generic case of a signal with nondegenerate maxima, we prove that the solution converges locally to a…
We consider a coupled bulk/surface model for advection and diffusion of interacting chemical species in biological cells. Specifically, we consider a signalling protein that can exist in both a cytosolic and a membrane-bound state, along…
The bulk-surface wave pinning model is a reaction-diffusion system for studying cell polarisation. It is constituted by a surface reaction-diffusion equation, coupled to a bulk diffusion equation with a non-linear boundary condition. Cell…
We introduce a nonlinear and nonlocal model that describes the range expansion of a population resulting from growth and competition for space. This type of phenomenon underlies the expansion of colonies of immotile cells which motivated…
We study the free boundary in an unstable parabolic problem arising from a model in combustion. We consider the physical situation in which the heat advances and prove that the free boundary is a $C^{1,\alpha/2}$ hypersurface.
This paper is concerned with a multi-dimensional free boundary problem modeling the growth of a tumor with two species of cells: proliferating cells and quiescent cells. This free boundary problem has a unique radial stationary solution. By…
In this paper we present an individual-based mechanical model that describes the dynamics of two contiguous cell populations with different proliferative and mechanical characteristics. An off-lattice modelling approach is considered…
In this paper, we establish the existence of a positive, bounded solution for a class of parabolic partial differential equations with nonlinear boundary conditions, where the boundary conditions depend on the solution on the boundary at a…
Signaling molecules play an important role for many cellular functions. We investigate here a general system of two membrane reaction-diffusion equations coupled to a diffusion equation inside the cell by a Robin-type boundary condition and…
Recently, the problem of boundary stabilization for unstable linear constant-coefficient coupled reaction-diffusion systems was solved by means of the backstepping method. The extension of this result to systems with advection terms and…
This article is concerned with a system of semilinear parabolic equations with two free boundaries describing the spreading fronts of the invasive species in a mutualistic ecological model. The local existence and uniqueness of a classical…
Cell polarity and movement are fundamental to many biological functions. Experimental and theoretically studies have indicated that interactions of certain proteins lead to the cell polarization which plays a key role in controlling the…
We study a free boundary problem modeling multi-layer tumor growth with a small time delay $\tau$, representing the time needed for the cell to complete the replication process. The model consists of two elliptic equations which describe…