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Chromosome analysis and identification from metaphase images is a critical part of cytogenetics based medical diagnosis. It is mainly used for identifying constitutional, prenatal and acquired abnormalities in the diagnosis of genetic…

Computer Vision and Pattern Recognition · Computer Science 2022-09-13 Amritha S Pallavoor , Prajwal A , Sundareshan TS , Sreekanth K Pallavoor

Chromosome enumeration is an essential but tedious procedure in karyotyping analysis. To automate the enumeration process, we develop a chromosome enumeration framework, DeepACEv2, based on the region based object detection scheme. The…

Computer Vision and Pattern Recognition · Computer Science 2020-07-21 Li Xiao , Chunlong Luo , Tianqi Yu , Yufan Luo , Manqing Wang , Fuhai Yu , Yinhao Li , Chan Tian , Jie Qiao

Chromosome recognition is an essential task in karyotyping, which plays a vital role in birth defect diagnosis and biomedical research. However, existing classification methods face significant challenges due to the inter-class similarity…

Computer Vision and Pattern Recognition · Computer Science 2023-12-14 Ruijia Chang , Suncheng Xiang , Chengyu Zhou , Kui Su , Dahong Qian , Jun Wang

We present a machine learning method capable of accurately detecting chromosome abnormalities that cause blood cancers directly from microscope images of the metaphase stage of cell division. The pipeline is built on a series of fine-tuned…

Automatic detection of dicentric chromosomes is an essential step to estimate radiation exposure and development of end to end emergency bio dosimetry systems. During accidents, a large amount of data is required to be processed for…

Computer Vision and Pattern Recognition · Computer Science 2022-04-19 Angad Singh Wadhwa , Nikhil Tyagi , Pinaki Roy Chowdhury

Chromosome karyotype analysis is of great clinical importance in the diagnosis and treatment of diseases, especially for genetic diseases. Since manual analysis is highly time and effort consuming, computer-assisted automatic chromosome…

Computer Vision and Pattern Recognition · Computer Science 2021-03-29 Liye Mei , Yalan Yu , Yueyun Weng , Xiaopeng Guo , Yan Liu , Du Wang , Sheng Liu , Fuling Zhou , Cheng Lei

Chromosome analysis is a fundamental step in the diagnosis of genetic diseases, but the manual karyotyping workflow is time-consuming and heavily dependent on expert specialists, often requiring several days per patient. Although Deep…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Jorge L. A. Lima , Filipe R. Cordeiro

With the wealth of medical image data, efficient curation is essential. Assigning the sequence type to magnetic resonance images is necessary for scientific studies and artificial intelligence-based analysis. However, incomplete or missing…

Image and Video Processing · Electrical Eng. & Systems 2024-08-01 Deepa Krishnaswamy , Bálint Kovács , Stefan Denner , Steve Pieper , David Clunie , Christopher P. Bridge , Tina Kapur , Klaus H. Maier-Hein , Andrey Fedorov

A difficult step in the process of karyotyping is segmenting chromosomes that touch or overlap. In an attempt to automate the process, previous studies turned to Deep Learning methods, with some formulating the task as a semantic…

Machine Learning · Computer Science 2022-03-25 Daniel Kluvanec , Thomas B. Phillips , Kenneth J. W. McCaffrey , Noura Al Moubayed

Using histopathological images to automatically classify cancer is a difficult task for accurately detecting cancer, especially to identify metastatic cancer in small image patches obtained from larger digital pathology scans. Computer…

Image and Video Processing · Electrical Eng. & Systems 2020-11-16 Guanwen Qiu , Xiaobing Yu , Baolin Sun , Yunpeng Wang , Lipei Zhang

Deep learning has led to state-of-the-art results for many medical imaging tasks, such as segmentation of different anatomical structures. With the increased numbers of deep learning publications and openly available code, the approach to…

Image and Video Processing · Electrical Eng. & Systems 2020-05-19 Tom van Sonsbeek , Veronika Cheplygina

Many strides have been made in semantic segmentation of multiple classes within an image. This has been largely due to advancements in deep learning and convolutional neural networks (CNNs). Features within a CNN are automatically learned…

Image and Video Processing · Electrical Eng. & Systems 2019-09-17 Erik Gaasedelen , Alex Deakyne , Paul Iaizzo

Accurately segmenting different organs from medical images is a critical prerequisite for computer-assisted diagnosis and intervention planning. This study proposes a deep learning-based approach for segmenting various organs from CT and…

The ability to quickly and accurately identify microbial species in a sample, known as metagenomic profiling, is critical across various fields, from healthcare to environmental science. This paper introduces a novel method to profile…

Genomics · Quantitative Biology 2025-04-10 Riselda Kodra , Hadjer Benmeziane , Irem Boybat , William Andrew Simon

As research interests in medical image analysis become increasingly fine-grained, the cost for extensive annotation also rises. One feasible way to reduce the cost is to annotate with coarse-grained superclass labels while using limited…

Computer Vision and Pattern Recognition · Computer Science 2023-07-04 Linrui Dai , Wenhui Lei , Xiaofan Zhang

Deep learning based approaches to Computer Aided Diagnosis (CAD) typically pose the problem as an image classification (Normal or Abnormal) problem. These systems achieve high to very high accuracy in specific disease detection for which…

Computer Vision and Pattern Recognition · Computer Science 2020-10-06 Aniket Joshi , Gaurav Mishra , Jayanthi Sivaswamy

Purpose: To determine whether deep learning models can distinguish between breast cancer molecular subtypes based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Materials and methods: In this institutional review…

Computer Vision and Pattern Recognition · Computer Science 2017-12-01 Zhe Zhu , Ehab Albadawy , Ashirbani Saha , Jun Zhang , Michael R. Harowicz , Maciej A. Mazurowski

Chromosome classification is critical for karyotyping in abnormality diagnosis. To expedite the diagnosis, we present a novel method named Varifocal-Net for simultaneous classification of chromosome's type and polarity using deep…

Computer Vision and Pattern Recognition · Computer Science 2019-03-21 Yulei Qin , Juan Wen , Hao Zheng , Xiaolin Huang , Jie Yang , Ning Song , Yue-Min Zhu , Lingqian Wu , Guang-Zhong Yang

Melanoma detection is vital for early diagnosis and effective treatment. While deep learning models on dermoscopic images have shown promise, they require specialized equipment, limiting their use in broader clinical settings. This study…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Volodymyr Sydorskyi , Igor Krashenyi , Oleksii Yakubenko

The rapid development of deep learning, a family of machine learning techniques, has spurred much interest in its application to medical imaging problems. Here, we develop a deep learning algorithm that can accurately detect breast cancer…

Computer Vision and Pattern Recognition · Computer Science 2019-10-08 Li Shen , Laurie R. Margolies , Joseph H. Rothstein , Eugene Fluder , Russell B. McBride , Weiva Sieh
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