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Purpose: Various dose calculation algorithms are available for radiation therapy for cancer patients. However, these algorithms are faced with the tradeoff between efficiency and accuracy. The fast algorithms are generally less accurate,…

Medical Physics · Physics 2020-07-01 Yixun Xing , Dan Nguyen , Weiguo Lu , Ming Yang , Steve Jiang

Conventional radiotherapy dose calculation algorithms are often computationally slow and non-differentiable, creating bottlenecks for online adaptive radiotherapy (ART) and limiting end-to-end automatic planning. Deep learning provides…

Modeling the absorbed dose during X-ray imaging is essential for optimizing radiation exposure. Monte Carlo simulations (MCS) are the gold standard for precise 3D dose estimation but require significant computation time. Deep learning…

Medical Physics · Physics 2025-02-14 Maxime Rousselot , Jing Zhang , Didier Benoit , Chi-Hieu Pham , Julien Bert

Purpose: Radiation therapy treatment planning is a trial-and-error, often time-consuming process. An optimal dose distribution based on a specific anatomy can be predicted by pre-trained deep learning (DL) models. However, dose…

Medical Physics · Physics 2021-09-15 Jianhui Ma , Dan Nguyen , Ti Bai , Michael Folkerts , Xun Jia , Weiguo Lu , Linghong Zhou , Steve Jiang

Volumetric Modulated Arc Therapy (VMAT) revolutionizes cancer treatment by precisely delivering radiation while sparing healthy tissues. Fluence maps generation, crucial in VMAT planning, traditionally involves complex and iterative, and…

Image and Video Processing · Electrical Eng. & Systems 2025-02-06 Simon Arberet , Florin C. Ghesu , Riqiang Gao , Martin Kraus , Jonathan Sackett , Esa Kuusela , Ali Kamen

Fast dose calculation is critical for online and real time adaptive therapy workflows. While modern physics-based dose algorithms must compromise accuracy to achieve low computation times, deep learning models can potentially perform dose…

Medical Physics · Physics 2023-07-19 Oscar Pastor-Serrano , Peng Dong , Charles Huang , Lei Xing , Zoltán Perkó

Purpose: This study aimed to use deep learning-based dose prediction to assess head and neck (HN) plan quality and identify suboptimal plans. Methods: A total of 245 VMAT HN plans were created using RapidPlan knowledge-based planning (KBP).…

In radiotherapy, a trade-off exists between computational workload/speed and dose calculation accuracy. Calculation methods like pencil-beam convolution can be much faster than Monte-Carlo methods, but less accurate. The dose difference,…

Medical Physics · Physics 2020-05-18 Yixun Xing , Ph. D. , You Zhang , Ph. D. , Dan Nguyen , Ph. D. , Mu-Han Lin , Ph. D. , Weiguo Lu , Ph. D. , Steve Jiang , Ph. D

This work aims to study the generalizability of a pre-developed deep learning (DL) dose prediction model for volumetric modulated arc therapy (VMAT) for prostate cancer and to adapt the model to three different internal treatment planning…

Accurate dose calculation is vitally important for proton therapy. Pencil beam (PB) model-based dose calculation is fast but inaccurate due to the approximation when dealing with inhomogeneities. Monte Carlo (MC) dose calculation is the…

Radiotherapy (RT) is a critical cancer treatment, with volumetric modulated arc therapy (VMAT) being a commonly used technique that enhances dose conformity by dynamically adjusting multileaf collimator (MLC) positions and monitor units…

Medical Physics · Physics 2025-06-26 Stefanos Achlatis , Efstratios Gavves , Jan-Jakob Sonke

In this work, we propose a new computing process, named DeepBEVdose, which is essentially distinct to the previous deep learning-based dose calculation methods.We present a novel image-domain dose calculation algorithm to automatically…

Medical Physics · Physics 2023-12-14 Jiawei Fan , Zhiqiang Liu , Dong Yang , Jiazhou Wang , Kuo Men , Jianrong Dai , Weigang Hu

The distribution of absorbed dose in radionuclide therapy with Lu$^{177}$ can be approximated by convolving an image of the time-integrated activity distribution with a dose voxel kernel representing different tissue types. This fast but…

Machine Learning · Statistics 2026-03-25 Luciano Melodia

We propose to develop deep learning models that can predict Pareto optimal dose distributions by using any given set of beam angles, along with patient anatomy, as input to train the deep neural networks. We implement and compare two deep…

Medical Physics · Physics 2021-01-27 Gyanendra Bohara , Azar Sadeghnejad Barkousaraie , Steve Jiang , Dan Nguyen

Purpose: To develop a machine learning-based, 3D dose prediction methodology for Gamma Knife (GK) radiosurgery. The methodology accounts for cases involving targets of any number, size, and shape. Methods: Data from 322 GK treatment plans…

Medical Physics · Physics 2023-01-09 Binghao Zhang , Aaron Babier , Timothy C. Y. Chan , Mark Ruschin

Currently, deep learning (DL) has achieved the automatic prediction of dose distribution in radiotherapy planning, enhancing its efficiency and quality. However, existing methods suffer from the over-smoothing problem for their commonly…

Image and Video Processing · Electrical Eng. & Systems 2023-11-07 Zhenghao Feng , Lu Wen , Peng Wang , Binyu Yan , Xi Wu , Jiliu Zhou , Yan Wang

Radiotherapy treatment planning currently requires many trail-and-error iterations between the planner and treatment planning system, as well as between the planner and physician for discussion/consultation. The physician's preferences for…

Medical Physics · Physics 2019-08-01 Dan Nguyen , Azar Sadeghnejad Barkousaraie , Chenyang Shen , Xun Jia , Steve Jiang

With the advancement of treatment modalities in radiation therapy for cancer patients, outcomes have improved, but at the cost of increased treatment plan complexity and planning time. The accurate prediction of dose distributions would…

Medical Physics · Physics 2018-12-03 Dan Nguyen , Troy Long , Xun Jia , Weiguo Lu , Xuejun Gu , Zohaib Iqbal , Steve Jiang

Deep learning (DL) 3D dose prediction has recently gained a lot of attention. However, the variability of plan quality in the training dataset, generated manually by planners with wide range of expertise, can dramatically effect the quality…

Computer Vision and Pattern Recognition · Computer Science 2021-06-08 Navdeep Dahiya , Gourav Jhanwar , Anthony Yezzi , Masoud Zarepisheh , Saad Nadeem

The treatment planning process for patients with head and neck (H&N) cancer is regarded as one of the most complicated due to large target volume, multiple prescription dose levels, and many radiation-sensitive critical structures near the…

Medical Physics · Physics 2019-03-27 Dan Nguyen , Xun Jia , David Sher , Mu-Han Lin , Zohaib Iqbal , Hui Liu , Steve Jiang
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