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Hyperspectral images capture vast amounts of high-dimensional spectral information about a scene, making labeling an intensive task that is resistant to out-of-the-box statistical methods. Unsupervised learning of clusters allows for…

Computer Vision and Pattern Recognition · Computer Science 2026-03-12 Joshua Lentz , Nicholas Karris , Alex Cloninger , James M. Murphy

Separating the contributions of individual chromogenic stains in RGB histology whole slide images (WSIs) is essential for stain normalization, quantitative assessment of marker expression, and cell-level readouts in immunohistochemistry…

Computer Vision and Pattern Recognition · Computer Science 2026-01-19 Mark Eastwood , Thomas McKee , Zedong Hu , Sabine Tejpar , Fayyaz Minhas

Automated semantic segmentation of whole-slide images (WSIs) stained with hematoxylin and eosin (H&E) is essential for large-scale artificial intelligence-based biomarker analysis in breast cancer. However, existing public datasets for…

Here we apply hyperspectral bright field imaging to collect computed tomographic images with excellent energy resolution (800 eV), applying it for the first time to map the distribution of stain in a fixed biological sample through its…

H&E-to-IHC stain translation techniques offer a promising solution for precise cancer diagnosis, especially in low-resource regions where there is a shortage of health professionals and limited access to expensive equipment. Considering the…

Image and Video Processing · Electrical Eng. & Systems 2024-09-04 Song Wang , Zhong Zhang , Huan Yan , Ming Xu , Guanghui Wang

Pigmented skin lesions represent localized areas of increased melanin and can indicate serious conditions like melanoma, a major contributor to skin cancer mortality. The MedMNIST v2 dataset, inspired by MNIST, was recently introduced to…

Image and Video Processing · Electrical Eng. & Systems 2025-07-18 Nerma Kadric , Amila Akagic , Medina Kapo

We study barycenters in the space of probability measures on a Riemannian manifold, equipped with the Wasserstein metric. Under reasonable assumptions, we establish absolute continuity of the barycenter of general measures $\Omega \in…

Analysis of PDEs · Mathematics 2015-10-05 Young-Heon Kim , Brendan Pass

Blood vessels (BVs) play a critical role in the Tumor Micro-Environment (TME), potentially influencing cancer progression and treatment response. However, manually quantifying BVs in Hematoxylin and Eosin (H&E) stained images is challenging…

Image and Video Processing · Electrical Eng. & Systems 2025-01-27 Jiaqi Lv , Stefan S Antonowicz , Shan E Ahmed Raza

Histological staining is a vital step used to diagnose various diseases and has been used for more than a century to provide contrast to tissue sections, rendering the tissue constituents visible for microscopic analysis by medical experts.…

Image and Video Processing · Electrical Eng. & Systems 2020-05-08 Yijie Zhang , Kevin de Haan , Yair Rivenson , Jingxi Li , Apostolos Delis , Aydogan Ozcan

We present a novel method for efficiently computing optimal transport maps and Wasserstein barycenters in high-dimensional spaces. Our approach uses conditional normalizing flows to approximate the input distributions as invertible…

Machine Learning · Statistics 2025-05-29 Gabriele Visentin , Patrick Cheridito

Manually annotating nuclei from the gigapixel Hematoxylin and Eosin (H&E)-stained Whole Slide Images (WSIs) is a laborious and costly task, meaning automated algorithms for cell nuclei instance segmentation and classification could…

Computer Vision and Pattern Recognition · Computer Science 2024-07-29 João D. Nunes , Diana Montezuma , Domingos Oliveira , Tania Pereira , Jaime S. Cardoso

We propose a study of a distribution registration model for general deformation functions. In this framework, we provide estimators of the deformations as well as a goodness of fit test of the model. For this, we consider a criterion which…

Statistics Theory · Mathematics 2015-10-02 Eustasio Del Barrio , Hélène Lescornel , Jean-Michel Loubes

In this paper we present a spatially-adaptive method for image reconstruction that is based on the concept of statistical multiresolution estimation as introduced in [Frick K, Marnitz P, and Munk A. "Statistical multiresolution Dantzig…

Applications · Statistics 2012-04-19 Klaus Frick , Philipp Marnitz , Axel Munk

In order to improve the accuracy of face recognition under varying illumination conditions, a local texture enhanced illumination normalization method based on fusion of differential filtering images (FDFI-LTEIN) is proposed to weaken the…

Computer Vision and Pattern Recognition · Computer Science 2019-05-13 Chaobing Zheng , Shiqian Wu , Wangming Xu , Shoulie Xie

The field of histology relies heavily on antiquated tissue processing and staining techniques that limit the efficiency of pathologic diagnoses of cancer and other diseases. Current staining and advanced labeling methods are often…

The morphology of blood vessels in retinal fundus images is an important indicator of diseases like glaucoma, hypertension and diabetic retinopathy. The accuracy of retinal blood vessels segmentation affects the quality of retinal image…

Computer Vision and Pattern Recognition · Computer Science 2018-03-02 A. M. R. R. Bandara , P. W. G. R. M. P. B. Giragama

Virtual staining of histopathology images (e.g., H&E-IHC) is an emerging tool in digital pathology, enabling faster and cheaper workflows by synthesizing target stains from routinely acquired slides. Yet, the quality of virtual staining…

Computer Vision and Pattern Recognition · Computer Science 2026-05-21 Fedor Gubanov , Svetlana Illarionova , Vlad Kozlovskiy , Mikhail Romanov , Yersultan Akhmetov , Aida Akaeva , Vyacheslav Grinevich , Rifat Hamoudi , Maxim Sharaev

Most publicly available brain MRI datasets are very homogeneous in terms of scanner and protocols, and it is difficult for models that learn from such data to generalize to multi-center and multi-scanner data. We propose a novel data…

Image and Video Processing · Electrical Eng. & Systems 2021-03-24 Maria Ines Meyer , Ezequiel de la Rosa , Nuno Barros , Roberto Paolella , Koen Van Leemput , Diana M. Sima

Leveraging multiple partially labeled datasets to train a model for multiple retinal disease screening reduces the reliance on fully annotated datasets, but remains challenging due to significant domain shifts across training datasets from…

Computer Vision and Pattern Recognition · Computer Science 2025-10-02 Boyi Zheng , Qing Liu

While diffusion models show promising results in image editing given a target prompt, achieving both prompt fidelity and background preservation remains difficult. Recent works have introduced score distillation techniques that leverage the…