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Deep learning (DL) methods where interpretability is intrinsically considered as part of the model are required to better understand the relationship of clinical and imaging-based attributes with DL outcomes, thus facilitating their use in…

Image and Video Processing · Electrical Eng. & Systems 2022-12-13 Irem Cetin , Maialen Stephens , Oscar Camara , Miguel Angel Gonzalez Ballester

Deep learning methods for classifying medical images have demonstrated impressive accuracy in a wide range of tasks but often these models are hard to interpret, limiting their applicability in clinical practice. In this work we introduce a…

Image and Video Processing · Electrical Eng. & Systems 2019-08-13 James R. Clough , Ilkay Oksuz , Esther Puyol-Anton , Bram Ruijsink , Andrew P. King , Julia A. Schnabel

Evaluation of predictive deep learning (DL) models beyond conventional performance metrics has become increasingly important for applications in sensitive environments like healthcare. Such models might have the capability to encode and…

Interpretability is essential in medical imaging to ensure that clinicians can comprehend and trust artificial intelligence models. In this paper, we propose a novel interpretable approach that combines attribute regularization of the…

Image and Video Processing · Electrical Eng. & Systems 2023-12-15 Maxime Di Folco , Cosmin I. Bercea , Julia A. Schnabel

We present a novel multimodal deep learning framework for cardiac resynchronisation therapy (CRT) response prediction from 2D echocardiography and cardiac magnetic resonance (CMR) data. The proposed method first uses the `nnU-Net'…

Image and Video Processing · Electrical Eng. & Systems 2021-07-23 Esther Puyol-Antón , Baldeep S. Sidhu , Justin Gould , Bradley Porter , Mark K. Elliott , Vishal Mehta , Christopher A. Rinaldi , Andrew P. King

Objective: To develop and interpret a supervised variational autoencoder (VAE) model for classifying cardiotocography (CTG) signals based on pregnancy outcomes, addressing interpretability limits of current deep learning approaches.…

Machine Learning · Computer Science 2025-09-09 John Tolladay , Beth Albert , Gabriel Davis Jones

Background. Clinical parameters measured from gated single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI) have value in predicting cardiac resynchronization therapy (CRT) patient outcomes, but still show…

Computer Vision and Pattern Recognition · Computer Science 2023-12-27 Kristoffer Larsena , Zhuo He , Chen Zhao , Xinwei Zhang , Quiying Sha , Claudio T Mesquitad , Diana Paeze , Ernest V. Garciaf , Jiangang Zou , Amalia Peix , Weihua Zhou

We present two deep generative models based on Variational Autoencoders to improve the accuracy of drug response prediction. Our models, Perturbation Variational Autoencoder and its semi-supervised extension, Drug Response Variational…

Machine Learning · Statistics 2017-07-07 Ladislav Rampasek , Daniel Hidru , Petr Smirnov , Benjamin Haibe-Kains , Anna Goldenberg

Alterations in the geometry and function of the heart define well-established causes of cardiovascular disease. However, current approaches to the diagnosis of cardiovascular diseases often rely on subjective human assessment as well as…

Computer Vision and Pattern Recognition · Computer Science 2018-07-19 Carlo Biffi , Ozan Oktay , Giacomo Tarroni , Wenjia Bai , Antonio De Marvao , Georgia Doumou , Martin Rajchl , Reem Bedair , Sanjay Prasad , Stuart Cook , Declan O'Regan , Daniel Rueckert

Agricultural image recognition tasks are becoming increasingly dependent on deep learning (DL); however, despite the excellent performance of DL, it is difficult to comprehend the type of logic or features of the input image it uses during…

Computer Vision and Pattern Recognition · Computer Science 2022-12-13 Harshana Habaragamuwa , Yu Oishi , Kenichi Tanaka

In the following short article we adapt a new and popular machine learning model for inference on medical data sets. Our method is based on the Variational AutoEncoder (VAE) framework that we adapt to survival analysis on small data sets…

Machine Learning · Statistics 2018-12-06 Cédric Beaulac , Jeffrey S. Rosenthal , David Hodgson

To safely deploy deep learning models in the clinic, a quality assurance framework is needed for routine or continuous monitoring of input-domain shift and the models' performance without ground truth contours. In this work, cardiac…

Image and Video Processing · Electrical Eng. & Systems 2023-05-22 Xiyao Jin , Yao Hao , Jessica Hilliard , Zhehao Zhang , Maria A. Thomas , Hua Li , Abhinav K. Jha , Geoffrey D. Hugo

We propose a cross-domain latent modulation mechanism within a variational autoencoders (VAE) framework to enable improved transfer learning. Our key idea is to procure deep representations from one data domain and use it as perturbation to…

Machine Learning · Computer Science 2020-12-23 Jinyong Hou , Jeremiah D. Deng , Stephen Cranefield , Xuejie Ding

Motivation: Despite advances in the computational analysis of high-throughput molecular profiling assays (e.g. transcriptomics), a dichotomy exists between methods that are simple and interpretable, and ones that are complex but with lower…

Machine Learning · Computer Science 2023-06-12 Pedro Henrique da Costa Avelar , Min Wu , Sophia Tsoka

We introduce a Deep Kernel Learning Variational Autoencoder (VAE-DKL) framework that integrates the generative power of a Variational Autoencoder (VAE) with the predictive nature of Deep Kernel Learning (DKL). The VAE learns a latent…

Machine Learning · Computer Science 2025-03-06 Boris N. Slautin , Utkarsh Pratiush , Doru C. Lupascu , Maxim A. Ziatdinov , Sergei V. Kalinin

This paper introduces the Descriptive Variational Autoencoder (DVAE), an unsupervised and end-to-end trainable neural network for predicting vehicle trajectories that provides partial interpretability. The novel approach is based on the…

Machine Learning · Computer Science 2021-06-25 Marion Neumeier , Andreas Tollkühn , Thomas Berberich , Michael Botsch

Chest X-Ray (CXR) is one of the most common diagnostic techniques used in everyday clinical practice all around the world. We hereby present a work which intends to investigate and analyse the use of Deep Learning (DL) techniques to extract…

Image and Video Processing · Electrical Eng. & Systems 2024-07-16 Leonardo Crespi , Daniele Loiacono , Arturo Chiti

Understanding how generative models represent and transform data is a foundational problem in deep learning interpretability. While mechanistic interpretability of discriminative architectures has yielded substantial insights, relatively…

Machine Learning · Computer Science 2026-04-07 Dip Roy , Rajiv Misra , Sanjay Kumar Singh , Anisha Roy

The analysis of electrocardiogram (ECG) signals can be time consuming as it is performed manually by cardiologists. Therefore, automation through machine learning (ML) classification is being increasingly proposed which would allow ML…

Machine Learning · Computer Science 2022-05-10 Shourya Verma

The increasing availability of electrocardiogram (ECG) data has motivated the use of data-driven models for automating various clinical tasks based on ECG data. The development of subject-specific models are limited by the cost and…

Machine Learning · Computer Science 2018-08-07 Prashnna K Gyawali , B. Milan Horacek , John L. Sapp , Linwei Wang
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