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Biomedical association studies are increasingly done using clinical concepts, and in particular diagnostic codes from clinical data repositories as phenotypes. Clinical concepts can be represented in a meaningful, vector space using word…

Quantitative Methods · Quantitative Biology 2018-11-06 Brett K. Beaulieu-Jones , Isaac S. Kohane , Andrew L. Beam

Knowledge graphs have garnered significant research attention and are widely used to enhance downstream applications. However, most current studies mainly focus on static knowledge graphs, whose facts do not change with time, and disregard…

Computation and Language · Computer Science 2024-03-11 Li Cai , Xin Mao , Yuhao Zhou , Zhaoguang Long , Changxu Wu , Man Lan

Embedding learning, a.k.a. representation learning, has been shown to be able to model large-scale semantic knowledge graphs. A key concept is a mapping of the knowledge graph to a tensor representation whose entries are predicted by models…

Artificial Intelligence · Computer Science 2016-05-10 Volker Tresp , Cristóbal Esteban , Yinchong Yang , Stephan Baier , Denis Krompaß

Standardising the representation of biomedical knowledge among all researchers is an insurmountable task, hindering the effectiveness of many computational methods. To facilitate harmonisation and interoperability despite this fundamental…

A large-scale knowledge graph enhances reproducibility in biomedical data discovery by providing a standardized, integrated framework that ensures consistent interpretation across diverse datasets. It improves generalizability by connecting…

Methodology · Statistics 2024-10-11 Suqi Liu , Tianxi Cai , Xiaoou Li

Within clinical, biomedical, and translational science, an increasing number of projects are adopting graphs for knowledge representation. Graph-based data models elucidate the interconnectedness between core biomedical concepts, enable…

Currently, there is a rapidly increasing need for high-quality biomedical knowledge graphs (BioKG) that provide direct and precise biomedical knowledge. In the context of COVID-19, this issue is even more necessary to be highlighted.…

Artificial Intelligence · Computer Science 2020-12-03 Sendong Zhao , Bing Qin , Ting Liu , Fei Wang

Knowledge Graphs, such as Wikidata, comprise structural and textual knowledge in order to represent knowledge. For each of the two modalities dedicated approaches for graph embedding and language models learn patterns that allow for…

Computation and Language · Computer Science 2023-08-21 Mojtaba Nayyeri , Zihao Wang , Mst. Mahfuja Akter , Mirza Mohtashim Alam , Md Rashad Al Hasan Rony , Jens Lehmann , Steffen Staab

``Classical'' word embeddings, such as Word2Vec, have been shown to capture the semantics of words based on their distributional properties. However, their ability to represent the different meanings that a word may have is limited. Such…

Computation and Language · Computer Science 2020-04-20 Lea Dieudonat , Kelvin Han , Phyllicia Leavitt , Esteban Marquer

Knowledge graphs have proven to be effective for modeling entities and their relationships through the use of ontologies. The recent emergence in interest for using knowledge graphs as a form of information modeling has led to their…

Artificial Intelligence · Computer Science 2023-07-21 Ngoc Luyen Le , Marie-Hélène Abel , Philippe Gouspillou

Computing latent representations for graph-structured data is an ubiquitous learning task in many industrial and academic applications ranging from molecule synthetization to social network analysis and recommender systems. Knowledge graphs…

Neural and Evolutionary Computing · Computer Science 2023-08-25 Victor Caceres Chian , Marcel Hildebrandt , Thomas Runkler , Dominik Dold

Knowledge representation is an important, long-history topic in AI, and there have been a large amount of work for knowledge graph embedding which projects symbolic entities and relations into low-dimensional, real-valued vector space.…

Computation and Language · Computer Science 2017-06-20 Han Xiao , Minlie Huang , Xiaoyan Zhu

Region based knowledge graph embeddings represent relations as geometric regions. This has the advantage that the rules which are captured by the model are made explicit, making it straightforward to incorporate prior knowledge and to…

Artificial Intelligence · Computer Science 2024-06-19 Victor Charpenay , Steven Schockaert

A knowledge graph (KG) is a data structure which represents entities and relations as the vertices and edges of a directed graph with edge types. KGs are an important primitive in modern machine learning and artificial intelligence.…

Artificial Intelligence · Computer Science 2021-10-20 Michael R. Douglas , Michael Simkin , Omri Ben-Eliezer , Tianqi Wu , Peter Chin , Trung V. Dang , Andrew Wood

Biomedical Question Answering aims to obtain an answer to the given question from the biomedical domain. Due to its high requirement of biomedical domain knowledge, it is difficult for the model to learn domain knowledge from limited…

Computation and Language · Computer Science 2022-06-29 Yuxuan Lu , Jingya Yan , Zhixuan Qi , Zhongzheng Ge , Yongping Du

The effectiveness of artificial intelligence (AI) in healthcare is significantly hindered by unstructured clinical documentation, which results in noisy, inconsistent, and logically fragmented training data. To address this challenge, we…

Machine Learning · Computer Science 2025-10-21 Dun Liu , Qin Pang , Guangai Liu , Hongyu Mou , Jipeng Fan , Yiming Miao , Pin-Han Ho , Limei Peng

Representation learning of knowledge graphs encodes entities and relation types into a continuous low-dimensional vector space, learns embeddings of entities and relation types. Most existing methods only concentrate on knowledge triples,…

Artificial Intelligence · Computer Science 2017-04-20 Mengya Wang , Hankui Zhuo , Huiling Zhu

Knowledge-intensive tasks pose a significant challenge for Machine Learning (ML) techniques. Commonly adopted methods, such as Large Language Models (LLMs), often exhibit limitations when applied to such tasks. Nevertheless, there have been…

Machine Learning · Computer Science 2024-05-20 Albert Sawczyn , Jakub Binkowski , Piotr Bielak , Tomasz Kajdanowicz

In recent years, word embeddings have been surprisingly effective at capturing intuitive characteristics of the words they represent. These vectors achieve the best results when training corpora are extremely large, sometimes billions of…

Computation and Language · Computer Science 2017-12-06 Willie Boag , Hassan Kané

Designing a new clinical trial entails many decisions, such as defining a cohort and setting the study objectives to name a few, and therefore can benefit from recommendations based on exhaustive mining of past clinical trial records. Here,…

Artificial Intelligence · Computer Science 2023-09-29 Murthy V. Devarakonda , Smita Mohanty , Raja Rao Sunkishala , Nag Mallampalli , Xiong Liu
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