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Hexagonal boron nitride (hBN) has emerged as a promising two-dimensional platform for quantum sensing, due to its optically addressable spin defects, such as the negatively charged boron vacancy ($V_{\text{B}}^-$). Despite hBN being…

Polymer syntactic foams are transforming materials that will shape the future of next-generation aerospace and marine structures. When manufactured using traditional processes, like compression molding, syntactic foams consist of a solid…

Applied Physics · Physics 2024-02-27 Hridyesh Tewani , Megan Hinaus , Mayukh Talukdar , Hiroki Sone , Pavana Prabhakar

Exerting forces on biomolecules inside living cells would allow us to probe their dynamic interactions in their native environment. Magnetic iron oxide nanoparticles represent a unique tool capable of pulling on biomolecules with the…

The OH-terminated self-assembled monolayers, as protein-resistant surfaces, have significant potential in biocompatible implant devices, which can avoid or reduce adverse reactions caused by protein adhesion to biomaterial surfaces, such as…

Applied Physics · Physics 2022-12-08 Dangxin Mao , Yuan-Yan Wu , Yusong Tu

Deep generative models have gained significant advancements to accelerate drug discovery by generating bioactive chemicals against desired targets. Nevertheless, most generated compounds that have been validated for potent bioactivity often…

Quantitative Methods · Quantitative Biology 2024-01-03 Weixin Xie , Jianhang Zhang , Qin Xie , Chaojun Gong , Youjun Xu , Luhua Lai , Jianfeng Pei

Hydrogen bonds and other non-covalent interactions play a crucial role in maintaining the structural integrity and functionality of biological macromolecules such as proteins and nucleic acids. Accurate identification and analysis of these…

Chemical Physics · Physics 2026-02-23 Abhishek Tiwari

By stabilizing weak and transient protein-protein interactions (PPIs), molecular glues address the challenge of targeting proteins previously considered undruggable. Rapamycin and WDB002 are molecular glues that bind to FK506-binding…

Biomolecules · Quantitative Biology 2025-11-03 Apoorva Mathur , Mariona Alegre Canela , Max von Graevenitz , Chiara Gerstner , Ariane Nunes-Alves

Molybdenum dithiocarbamates (MoDTCs) are lubricant additives very efficient in reducing the friction of steel and they are employed in a number of industrial applications. The functionality of these additives is ruled by the chemical…

Materials Science · Physics 2023-04-24 Stefan Peeters , Catherine Charrin , Isabelle Duron , Sophie Loehlé , Benoit Thiebaut , M. C. Righi

Spatial self-phase modulation (SSPM) is the optical nonlinear process and is a result of spatially varying refractive index profile along the line of propagation in a medium. SSPM is proved to be a method to demonstrate different photonic…

In view of their immensely intriguing properties, two dimensional materials are being intensely researched in search of novel phenomena and diverse application interests, however, studies on the realization of nanocomposites in the…

The biologically inspired spiking neurons used in neuromorphic computing are nonlinear filters with dynamic state variables -- very different from the stateless neuron models used in deep learning. The next version of Intel's neuromorphic…

The inclusion of small amounts of copper is often reported to enhance the mechanical and biointegrative performance of bioceramics towards tissue engineering applications. In this work, 3D scaffolds were additively manufactured by…

Medical Physics · Physics 2022-05-24 Shumin Pang , Dongwei Wu , Franz Kamutzki , Jens Kurreck , Aleksander Gurlo , Dorian A. H. Hanaor

The development and progression of arthritis is strongly associated with osteophytes, which are small and elusive bone growths. This paper presents one of the first efforts towards automated spinal osteophyte detection in spinal X-rays. A…

Computer Vision and Pattern Recognition · Computer Science 2024-03-01 Soumya Snigdha Kundu , Yuanhan Mo , Nicharee Srikijkasemwat , Bartłomiej W. Papiez

Cell-free translational strategies are needed to accelerate the repair of mineralised tissues, particularly large bone defects, using minimally invasive approaches. Regenerative bone scaffolds should ideally mimic aspects of the tissue's…

Tissues and Organs · Quantitative Biology 2021-01-06 Robabeh Gharaei , Giuseppe Tronci , Parikshit Goswami , Robert P. Wynn Davies , Jennifer Kirkham , Stephen J. Russell

Background: Mesenchymal stem cell (MSC) transplantation therapy is highly investigated for the regenerative repair of cartilage defects. Low-intensity pulsed ultrasound (LIPUS) has the potential to promote chondrogenic differentiation of…

Medical Physics · Physics 2023-04-20 Yiming Chen , Huiyi Yang , Zhaojie Wang , Rongrong Zhu , Liming Cheng , Qian Cheng

The reliability of the recently proposed natural orbital functional supplemented with second-order M{\o}ller-Plesset calculations, (NOF-MP2), has been assessed for the mechanistic studies of elementary reactions of transition metal…

Chemical Physics · Physics 2020-12-25 Jose M. Mercero , Jesus M. Ugalde , Mario Piris

Knee osteoporosis weakens the bone tissue in the knee joint, increasing fracture risk. Early detection through X-ray images enables timely intervention and improved patient outcomes. While some researchers have focused on diagnosing knee…

Image and Video Processing · Electrical Eng. & Systems 2024-12-13 Ayesha Siddiqua , Rakibul Hasan , Anichur Rahman , Abu Saleh Musa Miah

Considering the sensitivity of both fatigue strength and corrosion rate to the surface characteristics, apposite surface treatments could address the related challenges for biodegradable magnesium-based materials. Herein, we treated the…

Nanocomposite membranes are an emerging filtration material in the production of clean water. Recently, the fabrication of porous nanocomposite membranes via solvent transfer induced phase separation (STrIPS) was introduced. During STrIPS,…

Soft Condensed Matter · Physics 2023-01-31 Henrik Siegel , Mariska de Ruiter , Cos M. Hesseling , Georgios Athanasiou , Martin F. Haase

SnS2 stands out as a highly promising two-dimensional material with significant potential for applications in the field of electronics. Numerous attempts have been undertaken to modulate the physical properties of SnS2 by doping with…

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